5/8/2025
Last update
5/8/2025
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.5
USERS' SCORE
Medium or Average
Based on 16 Reviews
6.8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A (100% as Beta-Carotene)(from Blakeslea trispora and Sunflower Oil)
7,500 mcg
833%
Top Medical Research Studies
9
We focused on how all-trans retinoic acid (ATRA), a form of vitamin A, helps combat resistance in epithelial ovarian cancer (EOC) when combined with standard platinum-based chemotherapy, such as cisplatin.
Our findings indicate that ATRA effectively reduced PARP inhibitor resistance in EOC cells, both in lab settings and in animal models.
Additionally, using ATRA along with ongoing treatment improved survival rates in EOC-bearing mice. This suggests that ATRA could be an important part of future therapies for enhancing the effectiveness of existing treatments.
Our findings indicate that ATRA effectively reduced PARP inhibitor resistance in EOC cells, both in lab settings and in animal models.
Additionally, using ATRA along with ongoing treatment improved survival rates in EOC-bearing mice. This suggests that ATRA could be an important part of future therapies for enhancing the effectiveness of existing treatments.
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8
Retinoic acid enhances glioma treatment
We investigated how retinoic acid (RA), a derivative of vitamin A, could influence cancer treatment, particularly in glioma, a type of brain tumor. Previous attempts to use RA as a therapeutic option were inconclusive, so we aimed to explore its effects alongside extracellular ATP (eATP) to harness their combined potential.
Our experiments examined two human glioma cell lines, M059K and M059J, to see how they responded to RA-based differentiation. Notably, this process led to changes in the expression of a receptor called P2X7 and reduced the activity of enzymes that break down nucleotides. These modifications contributed to a significant decrease in cell proliferation and migration abilities, as well as an increased sensitivity to the effects of eATP.
Specifically, we found that in the presence of eATP, cell viability decreased by up to 40% in RA-treated M059K cells and 20% in M059J cells. Migration capabilities of the cells were reduced by as much as 60% when exposed to a specific concentration of ATP, showing that the P2X7 receptor plays a major role in mediating these effects.
Our observations suggest that combining retinoic acid with eATP can have anti-cancer benefits by influencing purinergic signaling pathways in glioma cells. This points to the need for further exploration of P2X7 receptor variants as potential therapeutic targets for treating glioma.
Our experiments examined two human glioma cell lines, M059K and M059J, to see how they responded to RA-based differentiation. Notably, this process led to changes in the expression of a receptor called P2X7 and reduced the activity of enzymes that break down nucleotides. These modifications contributed to a significant decrease in cell proliferation and migration abilities, as well as an increased sensitivity to the effects of eATP.
Specifically, we found that in the presence of eATP, cell viability decreased by up to 40% in RA-treated M059K cells and 20% in M059J cells. Migration capabilities of the cells were reduced by as much as 60% when exposed to a specific concentration of ATP, showing that the P2X7 receptor plays a major role in mediating these effects.
Our observations suggest that combining retinoic acid with eATP can have anti-cancer benefits by influencing purinergic signaling pathways in glioma cells. This points to the need for further exploration of P2X7 receptor variants as potential therapeutic targets for treating glioma.
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8
We investigated the role of Vitamin A, specifically retinoic acid, in enhancing the immune response of γδ T cells in patients with nasopharyngeal carcinoma (NPC). By analyzing blood samples, we observed that Vitamin A can reduce markers of immune exhaustion that are often elevated in cancer.
Importantly, our study showed that vitamin supplementation improved the antitumor activity of T cells by decreasing a specific protein linked to immune fatigue. This suggests that Vitamin A could be a valuable ally in cancer therapies, potentially opening doors for more effective immunotherapy options.
Importantly, our study showed that vitamin supplementation improved the antitumor activity of T cells by decreasing a specific protein linked to immune fatigue. This suggests that Vitamin A could be a valuable ally in cancer therapies, potentially opening doors for more effective immunotherapy options.
Read More
Most Useful Reviews
7.5
Antioxidant properties
26 people found this helpful
This product contains beta-carotene derived from algae and vegetables, serving as a potent antioxidant. It has numerous health benefits, including strengthening the immune system and reducing the risk of cancer and heart disease. Research indicates that individuals consuming four servings of beta-carotene daily have a decreased likelihood of developing cancer. While the price is slightly high, the health benefits offer excellent value. I genuinely appreciate those who find this review helpful.
Read More
7.5
Enhances immunity
3 people found this helpful
A healthy mind is found in a healthy body! When ingested, beta-carotene transforms into retinol, a vital precursor to vitamin A. It requires fats for absorption. This provitamin helps deliver retinol while shielding cells from cancer radicals and preventing heart diseases. It even lowers cholesterol levels. I take it twice annually paired with vitamin D3 during meals that include fat. I hope this review is beneficial!
Read More
0
Caution for smokers
1 people found this helpful
Exercise caution if you smoke. Smokers, former smokers, and asbestos workers should avoid isolated beta-carotene supplements due to evidence suggesting they may increase lung cancer risk.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.5
- All Researches
9.5
We constructed a zebrafish model to explore how a unique version of the PML-RARA protein, linked to acute promyelocytic leukemia (APL), might respond to treatment with all-trans retinoic acid (ATRA). This model allowed us to examine whether ATRA, a derivative of vitamin A, could be effective for patients with atypical APL characteristics.
In our findings, we observed that the response of the new PML-RARA isoform to ATRA treatment was similar to classical isoforms seen in the condition. We also found that ATRA worked well in this model, leading to favorable results for the treated patient, who reached complete remission shortly after starting therapy with ATRA and arsenic trioxide (ATO).
These results highlight the promising potential of vitamin A derivatives in cancer treatment, especially in various forms of APL. It's encouraging to see that ATRA can lead to substantial recovery, further supporting its use in clinical settings alongside other therapies.
In our findings, we observed that the response of the new PML-RARA isoform to ATRA treatment was similar to classical isoforms seen in the condition. We also found that ATRA worked well in this model, leading to favorable results for the treated patient, who reached complete remission shortly after starting therapy with ATRA and arsenic trioxide (ATO).
These results highlight the promising potential of vitamin A derivatives in cancer treatment, especially in various forms of APL. It's encouraging to see that ATRA can lead to substantial recovery, further supporting its use in clinical settings alongside other therapies.
Read More
9.5
Promising APL treatment outcomes observed
We aimed to understand the effectiveness of a combination treatment involving all-trans retinoic acid (ATRA), arsenic trioxide (ATO), and gemtuzumab ozogamicin (GO) for patients with acute promyelocytic leukemia (APL). This was a phase 2 trial involving newly diagnosed APL patients, where ATRA and ATO were used to induce remission.
The results were promising, as we observed a complete remission rate of 93.8% among the participants. Furthermore, 97.1% of those who achieved remission had no measurable residual disease, indicating a strong initial response to the treatment regimen.
Over a median follow-up of about 62 months, the 5-year survival rates were also impressive, with event-free survival at 92.4%, disease-free survival at 93.6%, and overall survival at 93.1%. We noted some side effects, including elevated liver enzymes and infections, but there were no severe complications like veno-occlusive disease.
While the study highlights the benefits of ATRA in this combination treatment, we must clarify that we cannot specifically isolate the effect of vitamin A, as it was part of a broader therapeutic approach. Nonetheless, the combination of ATRA with other agents showed significant success in treating APL, reinforcing the importance of multifaceted cancer therapies.
The results were promising, as we observed a complete remission rate of 93.8% among the participants. Furthermore, 97.1% of those who achieved remission had no measurable residual disease, indicating a strong initial response to the treatment regimen.
Over a median follow-up of about 62 months, the 5-year survival rates were also impressive, with event-free survival at 92.4%, disease-free survival at 93.6%, and overall survival at 93.1%. We noted some side effects, including elevated liver enzymes and infections, but there were no severe complications like veno-occlusive disease.
While the study highlights the benefits of ATRA in this combination treatment, we must clarify that we cannot specifically isolate the effect of vitamin A, as it was part of a broader therapeutic approach. Nonetheless, the combination of ATRA with other agents showed significant success in treating APL, reinforcing the importance of multifaceted cancer therapies.
Read More
9
We investigated the effects of beta-lactoglobulin (BLG) hydrolysis on generating peptides with potential anticancer properties. By using varying hydrolysis times, we discovered that the 60-minute hydrolysate displayed significant antioxidant activity, alongside 162 distinctive peptides.
Notably, this hydrolysate demonstrated strong anticancer effects across several human cancer cell lines, promoting cell death and inhibiting blood vessel formation. While these findings highlight promising anticancer capabilities, future research will focus on isolating specific peptides to improve effectiveness even further.
Notably, this hydrolysate demonstrated strong anticancer effects across several human cancer cell lines, promoting cell death and inhibiting blood vessel formation. While these findings highlight promising anticancer capabilities, future research will focus on isolating specific peptides to improve effectiveness even further.
Read More
9
We investigated how co-exposure to various carotenoids impacts mortality risks among nearly 22,500 adults. By examining serum levels of carotenoids like β-carotene over 16 years, we noted that participants with higher levels had a significantly lower risk of death from all causes, cardiovascular disease, and even cancer.
Interestingly, both the high-lycopene and high-level carotenoid groups showed a notable reduction in cancer mortality risk, suggesting that increasing carotenoid intake could have potential health benefits. However, more research is needed to fully understand how these carotenoids work together.
Interestingly, both the high-lycopene and high-level carotenoid groups showed a notable reduction in cancer mortality risk, suggesting that increasing carotenoid intake could have potential health benefits. However, more research is needed to fully understand how these carotenoids work together.
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9
We observed that certain types of Acute Myeloid Leukemia (AML), specifically acute erythroleukemia and acute megakaryocytic leukemia, have a concerningly short median survival and limited effective treatment options. Our exploration focused on understanding the role of the transcription factor GATA1, which is crucial for the survival of cells in these leukemia subtypes. Remarkably, we discovered that a compound known as Fenretinide (or 4-HPR), a synthetic derivative of vitamin A, can target and induce loss of GATA1 in these AML cells.
As we delved into the study, we found that treating M6 AML cells with low concentrations of 4-HPR led to significant cytotoxic effects, akin to reducing GATA1 levels through genetic methods. This indicates that 4-HPR could act similar to a targeted therapy, directly impacting the survival of these cancer cells. Further, we were encouraged to see that 4-HPR not only performed effectively on its own but also enhanced the effectiveness of existing treatments like Azacytidine and Venetoclax, which typically struggle against drug resistance.
Our findings suggest that 4-HPR might represent a promising therapeutic avenue for patients with M6 and M7 AML, paving the way for its potential inclusion as a standard treatment option in the near future. The safety profile of Fenretinide, established through numerous clinical trials, further strengthens the case for its application in the combat against these aggressive forms of leukemia.
As we delved into the study, we found that treating M6 AML cells with low concentrations of 4-HPR led to significant cytotoxic effects, akin to reducing GATA1 levels through genetic methods. This indicates that 4-HPR could act similar to a targeted therapy, directly impacting the survival of these cancer cells. Further, we were encouraged to see that 4-HPR not only performed effectively on its own but also enhanced the effectiveness of existing treatments like Azacytidine and Venetoclax, which typically struggle against drug resistance.
Our findings suggest that 4-HPR might represent a promising therapeutic avenue for patients with M6 and M7 AML, paving the way for its potential inclusion as a standard treatment option in the near future. The safety profile of Fenretinide, established through numerous clinical trials, further strengthens the case for its application in the combat against these aggressive forms of leukemia.
Read More
User Reviews
USERS' SCORE
Medium or Average
Based on 16 Reviews
6.8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Antioxidant properties
26 people found this helpful
This product contains beta-carotene derived from algae and vegetables, serving as a potent antioxidant. It has numerous health benefits, including strengthening the immune system and reducing the risk of cancer and heart disease. Research indicates that individuals consuming four servings of beta-carotene daily have a decreased likelihood of developing cancer. While the price is slightly high, the health benefits offer excellent value. I genuinely appreciate those who find this review helpful.
Read More
7.5
Enhances immunity
3 people found this helpful
A healthy mind is found in a healthy body! When ingested, beta-carotene transforms into retinol, a vital precursor to vitamin A. It requires fats for absorption. This provitamin helps deliver retinol while shielding cells from cancer radicals and preventing heart diseases. It even lowers cholesterol levels. I take it twice annually paired with vitamin D3 during meals that include fat. I hope this review is beneficial!
Read More
0
Caution for smokers
1 people found this helpful
Exercise caution if you smoke. Smokers, former smokers, and asbestos workers should avoid isolated beta-carotene supplements due to evidence suggesting they may increase lung cancer risk.
Read More
7.5
Highly recommended
This beta-carotene product is fantastic! As a natural antioxidant, it protects against free radicals that can damage cells. Key benefits include enhancing the immune system and lowering the risk of cancer and heart conditions. I am pleased with the quality, quantity, and delightful taste. I would highly recommend it to anyone looking to improve their health.
Read More
7.5
Protects against cancer
Beta-carotene provides vibrant colour in many vegetables and is a precursor to vitamin A. It demonstrates strong antioxidant properties which may help protect against conditions like certain cancers and heart disease. I've found that NOW vitamins maintain high quality in their ingredients. This product gives me confidence in safeguarding my health.
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Frequently Asked Questions
6
Improves skin health
23 people found this helpful
I highly recommend this beta-carotene, which I take twice a year alongside vitamin E. It effectively converts to vitamin A in the liver. Be cautious, as it shouldn't be consumed for more than 1.5 to 2 months due to accumulation in the body. In cases of acidosis, the combination of water, vitamin A, and vitamin C aids in fighting cancer cells and supporting immunity. After two weeks, I noticed a remarkable difference in my skin’s appearance. I hope this review proves useful!
7.5
Enhances immunity
3 people found this helpful
A healthy mind is found in a healthy body! When ingested, beta-carotene transforms into retinol, a vital precursor to vitamin A. It requires fats for absorption. This provitamin helps deliver retinol while shielding cells from cancer radicals and preventing heart diseases. It even lowers cholesterol levels. I take it twice annually paired with vitamin D3 during meals that include fat. I hope this review is beneficial!
7.5
Antioxidant properties
26 people found this helpful
This product contains beta-carotene derived from algae and vegetables, serving as a potent antioxidant. It has numerous health benefits, including strengthening the immune system and reducing the risk of cancer and heart disease. Research indicates that individuals consuming four servings of beta-carotene daily have a decreased likelihood of developing cancer. While the price is slightly high, the health benefits offer excellent value. I genuinely appreciate those who find this review helpful.
7.5
Highly recommended
This beta-carotene product is fantastic! As a natural antioxidant, it protects against free radicals that can damage cells. Key benefits include enhancing the immune system and lowering the risk of cancer and heart conditions. I am pleased with the quality, quantity, and delightful taste. I would highly recommend it to anyone looking to improve their health.
7.5
Reduced cancer risk
Vitamin A is essential for vision, including night vision, and contributes to various bodily processes such as growth, skin renewal, and immune regulation. It aids in wound healing and protects the skin from sun damage. Beta-carotene, an antioxidant, is known to help lower risks of cancers including those of the bladder, mouth, larynx, breast, and colon. I take it periodically, engage in sports, and find it beneficial—great price and dosage! I highly recommend it!
6
Supports immunity
269 people found this helpful
Beta-carotene and carotenoids are precursors to vitamin A, which the liver produces. It's important to know that vitamin A is non-toxic, as the body regulates absorption. When the body experiences acidosis, combining water with vitamin A and vitamin C can help combat cancer cells and boost immunity. This vitamin also alleviates dry skin issues such as on heels, elbows, and knees, whilst helping with conjunctivitis and hormonal imbalances. I hope this information is helpful. Stay healthy!
0
Caution for smokers
1 people found this helpful
Exercise caution if you smoke. Smokers, former smokers, and asbestos workers should avoid isolated beta-carotene supplements due to evidence suggesting they may increase lung cancer risk.
9.5
Promising APL treatment outcomes observed
We aimed to understand the effectiveness of a combination treatment involving all-trans retinoic acid (ATRA), arsenic trioxide (ATO), and gemtuzumab ozogamicin (GO) for patients with acute promyelocytic leukemia (APL). This was a phase 2 trial involving newly diagnosed APL patients, where ATRA and ATO were used to induce remission.
The results were promising, as we observed a complete remission rate of 93.8% among the participants. Furthermore, 97.1% of those who achieved remission had no measurable residual disease, indicating a strong initial response to the treatment regimen.
Over a median follow-up of about 62 months, the 5-year survival rates were also impressive, with event-free survival at 92.4%, disease-free survival at 93.6%, and overall survival at 93.1%. We noted some side effects, including elevated liver enzymes and infections, but there were no severe complications like veno-occlusive disease.
While the study highlights the benefits of ATRA in this combination treatment, we must clarify that we cannot specifically isolate the effect of vitamin A, as it was part of a broader therapeutic approach. Nonetheless, the combination of ATRA with other agents showed significant success in treating APL, reinforcing the importance of multifaceted cancer therapies.
The results were promising, as we observed a complete remission rate of 93.8% among the participants. Furthermore, 97.1% of those who achieved remission had no measurable residual disease, indicating a strong initial response to the treatment regimen.
Over a median follow-up of about 62 months, the 5-year survival rates were also impressive, with event-free survival at 92.4%, disease-free survival at 93.6%, and overall survival at 93.1%. We noted some side effects, including elevated liver enzymes and infections, but there were no severe complications like veno-occlusive disease.
While the study highlights the benefits of ATRA in this combination treatment, we must clarify that we cannot specifically isolate the effect of vitamin A, as it was part of a broader therapeutic approach. Nonetheless, the combination of ATRA with other agents showed significant success in treating APL, reinforcing the importance of multifaceted cancer therapies.
8
We investigated the role of Vitamin A, specifically retinoic acid, in enhancing the immune response of γδ T cells in patients with nasopharyngeal carcinoma (NPC). By analyzing blood samples, we observed that Vitamin A can reduce markers of immune exhaustion that are often elevated in cancer.
Importantly, our study showed that vitamin supplementation improved the antitumor activity of T cells by decreasing a specific protein linked to immune fatigue. This suggests that Vitamin A could be a valuable ally in cancer therapies, potentially opening doors for more effective immunotherapy options.
Importantly, our study showed that vitamin supplementation improved the antitumor activity of T cells by decreasing a specific protein linked to immune fatigue. This suggests that Vitamin A could be a valuable ally in cancer therapies, potentially opening doors for more effective immunotherapy options.
8
Beta-carotene enhances nanoparticle efficacy
We explored the effects of beta-carotene-coated zinc oxide nanoparticles (BT-ZnO NPs) on cancer and antimicrobial activity, specifically in dental applications. The study showcased impressive results, with BT-ZnO NPs showing strong inhibition against dental pathogens and notable effectiveness in reducing the proliferation of oral cancer cells.
Molecular docking studies revealed strong interactions with key proteins, hinting at a promising therapeutic path. While the results are encouraging, they suggest that further research is needed to fully understand the potential benefits of this treatment for cancer and infections.
Molecular docking studies revealed strong interactions with key proteins, hinting at a promising therapeutic path. While the results are encouraging, they suggest that further research is needed to fully understand the potential benefits of this treatment for cancer and infections.
7
We tested pumpkin carotenoid extracts from eight varieties for their effects on neuroblastoma cells. Our findings showed that these pumpkin extracts can be cytotoxic to these cancer cells, especially Butternut and Mantovana varieties, which were effective at specific concentrations over certain durations.
Additionally, we observed strong antioxidant activity, indicating the potential health benefits of pumpkin bioactives. Overall, this study suggests that pumpkin carotenoids, particularly β-carotene, may play a role in cancer treatment, possibly serving as supportive therapies.
Additionally, we observed strong antioxidant activity, indicating the potential health benefits of pumpkin bioactives. Overall, this study suggests that pumpkin carotenoids, particularly β-carotene, may play a role in cancer treatment, possibly serving as supportive therapies.
References
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- Shaik MR, Panda SP, Hussain SA, Deepak P, Thiyagarajulu N, et al. Enhancing the efficacy of zinc oxide nanoparticles by beta-carotene conjugation for improved anti-microbial and anti-tumor therapy for dental application. Pharm Dev Technol. 2025;30:101. 10.1080/10837450.2024.2448620
- Pinna N, Ianni F, Conte C, Codini M, di Vito R, et al. Carotenoids from Different Pumpkin Varieties Exert a Cytotoxic Effect on Human Neuroblastoma SH-SY5Y Cells. Nutrients. 2024;16. 10.3390/nu16173043
- Feunaing RT, Tamfu AN, Gbaweng AJY, Djoko CLT, Ntchapda F, et al. 3,3'4-trimethoxy-4'-rutinosylellagic acid and its acetylated derivative: Antioxidant activity and antiproliferative effects on breast cancer cells and molecular docking study. Biomed Pharmacother. 2024;179:117370. 10.1016/j.biopha.2024.117370
- Dulińska-Litewka J, Dykas K, Boznański S, Hałubiec P, Kaczor-Kamińska M, et al. The Influence of β-Carotene and Its Liposomal Form on the Expression of EMT Markers and Androgen-Dependent Pathways in Different Prostate Cell Lines. Antioxidants (Basel). 2024;13. 10.3390/antiox13080902
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- Park SH, Lee J, Jung SY, Park S, Kang YH, et al. Association between dietary carotenoid intake and breast cancer risk: a case-control study among Korean women. Int J Food Sci Nutr. 2024;75:496. 10.1080/09637486.2024.2358111
- Mere Del Aguila E, Tang XH, Gudas LJ. Retinoic acid receptor-β deletion in a model of early pancreatic ductal adenocarcinoma (PDAC) tumorigenesis. Am J Cancer Res. 2025;15:127. 10.62347/XFOT8509
- Raza Y, Yu G, Chiappone SB, Liu S, Luberto C. Fenretinide targets GATA1 to induce cytotoxicity in GATA1 positive Acute Erythroid and Acute Megakaryoblastic Leukemic cells. bioRxiv. 2025. 10.1101/2025.01.19.633759
- Motoyama M, Shigefuku R, Tanaka N, Nishizawa M, Oshio K, et al. Acyclic Retinoid Inhibits the EGFR/AKT Signaling Pathway and Cancels Cisplatin-resistant Cell Characteristics. Anticancer Res. 2025;45:433. 10.21873/anticanres.17432
- Balasundaram N, Narayanan MA, Antony LSA, Kumar SR, Anandan S. Effectiveness of Fenugreek as an Adjuvant in the Management of Oral Potentially Malignant Disorders: A Randomized Controlled Trial. J Contemp Dent Pract. 2024;25:921. 10.5005/jp-journals-10024-3773
- Piotrowsky A, Burkard M, Schmieder H, Venturelli S, Renner O, et al. The therapeutic potential of vitamins A, C, and D in pancreatic cancer. Heliyon. 2025;11:e41598. 10.1016/j.heliyon.2024.e41598
- Ye Y, Zhao Z, Mo W, Liu W, Wu L, et al. Zebrafish modeling of atypical PML-RARA isoform from acute promyelocytic leukemia patient and its implications for clinical treatment. Ann Hematol. 2025;104:171. 10.1007/s00277-024-06169-x
- Kocher HM, Sasieni P, Corrie P, McNamara MG, Sarker D, et al. Study protocol: multi-centre, randomised controlled clinical trial exploring stromal targeting in locally advanced pancreatic cancer; STARPAC2. BMC Cancer. 2025;25:106. 10.1186/s12885-024-13333-z
- Işlek Köklü Z, Şanverdi EL, Karadağ B, Üçişik MH, Taşkan E, et al. Combinational therapy of all-trans retinoic acid (ATRA) and sphingomyelin induces apoptosis and cell cycle arrest in B16F10 melanoma cancer cells. Turk J Biol. 2024;48:401. 10.55730/1300-0152.2715
- Aydin D, Öner Ç, Aslan Öztürk S, Çolak E. Short-term effects of retinoic acid on the proliferation of SH-SY5Y cells via mitophagy and apoptosis. Cell Mol Biol (Noisy-le-grand). 2024;70:64. 10.14715/cmb/2024.70.11.9
- Sánchez-Mendoza SE, de Deus-Wagatsuma VM, do Nascimento MC, Lima K, Machado-Neto JA, et al. All-trans retinoic acid potentiates cell death induced by quizartinib in acute myeloid leukemia with FLT3-ITD mutations. Ann Hematol. 2024;103:5405. 10.1007/s00277-024-06089-w
- Kanai M, Shinagawa A, Ota M, Virgona N, Yano T. Resveratrol Can Differentiate Human Melanoma Stem-like Cells from Spheroids Treated With All-trans Retinoic Acid. Anticancer Res. 2024;44:5283. 10.21873/anticanres.17356
- Szymczak B, Pegoraro A, De Marchi E, Grignolo M, Maciejewski B, et al. Retinoic acid-induced alterations enhance eATP-mediated anti-cancer effects in glioma cells: Implications for P2X7 receptor variants as key players. Biochim Biophys Acta Mol Basis Dis. 2025;1871:167611. 10.1016/j.bbadis.2024.167611
- Jen WY, Marvin-Peek J, Kantarjian HM, Alvarado Y, Borthakur G, et al. Long-term follow-up of a phase 2 study of all-trans retinoic acid, arsenic trioxide, and gemtuzumab ozogamicin in acute promyelocytic leukemia. Cancer. 2025;131:e35662. 10.1002/cncr.35662
- Liu G, Quan Q, Pan L, Duan H, Zhang G, et al. Retinoic acid enhances γδ T cell cytotoxicity in nasopharyngeal carcinoma by reversing immune exhaustion. Cell Commun Signal. 2025;23:156. 10.1186/s12964-025-02161-8
- Nurseta T, Indrawan IWA, Gunawan DA, Pramudia Wardani KR. Effects Atra on MMP-9 Activity and Integrin Expression in Choriocarcinoma Culture Cell Line Bewo (ATCC CCL-98). Asian Pac J Cancer Prev. 2025;26:1027. 10.31557/APJCP.2025.26.3.1027
- Mei B, Li J, Wang D, Feng L, Huang J, et al. All-trans Retinoic Acid Sensitizes Epithelial Ovarian Cancer to PARP Inhibition after Exposure to Cisplatin. Mol Cancer Ther. 2025;24:453. 10.1158/1535-7163.MCT-24-0140
