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SCIENTIFIC SCORE
Moderately Effective
Based on 19 Researches
8.1
USERS' SCORE
Good
Based on 7 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Polyunsaturated Fat
1 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Docosahexaenoic Acid (DHA)
500 mg
†
Eicosapentaenoic Acid (EPA)
250 mg
†
Top Medical Research Studies
9
DHA shows stroke protection potential
Docosahexaenoic acid protects against ischemic stroke in diabetic mice by inhibiting inflammatory responses and apoptosis.
Highly relevant assessment of DHA
We aimed to find out whether docosahexaenoic acid (DHA) could offer protection against ischemic stroke in diabetic mice and better understand how it works. In our study, we administered DHA to diabetic mice after they experienced an ischemic stroke and evaluated their recovery over 24 hours and again at three days.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
Read More
9
Eicosapentaenoic Acid reduces stroke risk
Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies.
Highly relevant to stroke prevention
We investigated the relationship between eicosapentaenoic acid (EPA) levels and stroke risk by pooling data from 29 international studies, involving over 183,000 participants. Our goal was to understand how circulating and tissue omega-3 fatty acid levels, specifically EPA, affect the occurrence of different types of stroke, including total, ischemic, and hemorrhagic strokes.
Our findings revealed that higher levels of EPA are linked to a lower risk of both total and ischemic strokes. For participants who had the highest levels of EPA, there was a 17% lower incidence of total strokes compared to those with the lowest levels, and an 18% reduction in ischemic strokes. This suggests that increasing EPA intake could be beneficial in reducing the risk of these stroke types.
However, it's important to note that EPA showed no significant relationship with hemorrhagic stroke risk. This indicates that while EPA may help prevent some stroke types, it does not appear to reduce the risk of bleeding strokes. These results were consistent across various demographics, regardless of whether participants had a history of atrial fibrillation or existing cardiovascular disease. Overall, our study presents strong evidence that EPA can be a valuable addition to dietary strategies aimed at reducing stroke risks.
Our findings revealed that higher levels of EPA are linked to a lower risk of both total and ischemic strokes. For participants who had the highest levels of EPA, there was a 17% lower incidence of total strokes compared to those with the lowest levels, and an 18% reduction in ischemic strokes. This suggests that increasing EPA intake could be beneficial in reducing the risk of these stroke types.
However, it's important to note that EPA showed no significant relationship with hemorrhagic stroke risk. This indicates that while EPA may help prevent some stroke types, it does not appear to reduce the risk of bleeding strokes. These results were consistent across various demographics, regardless of whether participants had a history of atrial fibrillation or existing cardiovascular disease. Overall, our study presents strong evidence that EPA can be a valuable addition to dietary strategies aimed at reducing stroke risks.
Read More
9
DHA enhances stroke recovery efforts
Docosahexaenoic acid promotes M2 microglia phenotype via activating PPARγ-mediated ERK/AKT pathway against cerebral ischemia-reperfusion injury.
Direct investigation of DHA effects
We set out to explore the impact of docosahexaenoic acid (DHA) on strokes, particularly how it influences microglia—those essential cells in our brain that can either harm or heal after an injury.
In our study, we administered DHA to rats who had undergone an ischemia-reperfusion injury, a condition that simulates a stroke. Over three days, we observed significant changes in the brain's response. DHA not only improved overall brain health but also swayed microglia towards a protective, anti-inflammatory M2 phenotype rather than a damaging, inflammatory M1 state.
We noted that DHA reduced markers associated with the harmful M1 phenotype and boosted those linked to the beneficial M2 phenotype. Additionally, it activated pathways involving PPARγ that further moderated brain inflammation, which is crucial for recovery after a stroke.
Overall, the results suggest that DHA holds promise as a therapeutic strategy to aid recovery from strokes by promoting healthier microglial behavior and reducing harmful inflammation, paving the way for improved neurological outcomes.
In our study, we administered DHA to rats who had undergone an ischemia-reperfusion injury, a condition that simulates a stroke. Over three days, we observed significant changes in the brain's response. DHA not only improved overall brain health but also swayed microglia towards a protective, anti-inflammatory M2 phenotype rather than a damaging, inflammatory M1 state.
We noted that DHA reduced markers associated with the harmful M1 phenotype and boosted those linked to the beneficial M2 phenotype. Additionally, it activated pathways involving PPARγ that further moderated brain inflammation, which is crucial for recovery after a stroke.
Overall, the results suggest that DHA holds promise as a therapeutic strategy to aid recovery from strokes by promoting healthier microglial behavior and reducing harmful inflammation, paving the way for improved neurological outcomes.
Read More
Most Useful Reviews
9.5
Stimulates recovery
This is a great supplement for the brain, particularly beneficial for schoolchildren and those recovering from a stroke, as it aids memory and concentration.
Read More
8
Good for stroke
Price-quality ratio is excellent. I choose a DHA supplement with 500 or 1,000 mg of DHA for brain and vision health. It also benefits the heart and blood vessels post-stroke. I use it consistently for three months or longer. If this review is helpful, please give a thumbs up.
Read More
8.8
Prevents stroke risk
DHA levels drop in the elderly, increasing the risk of memory loss. Supplementing with DHA promotes brain and eye development, reduces the risk of dementia, and may decrease stroke risk. A daily dose of 500–1,700 mg can enhance brain function and alleviate stress.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 19 Researches
8.1
9
DHA shows stroke protection potential
Docosahexaenoic acid protects against ischemic stroke in diabetic mice by inhibiting inflammatory responses and apoptosis.
Highly relevant assessment of DHA
We aimed to find out whether docosahexaenoic acid (DHA) could offer protection against ischemic stroke in diabetic mice and better understand how it works. In our study, we administered DHA to diabetic mice after they experienced an ischemic stroke and evaluated their recovery over 24 hours and again at three days.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
Read More
9
Docosahexaenoic acid reduces stroke risk
The association between fatty acids and atherosclerotic diseases: A mendelian randomization study.
Relevant but non-isolated factors
We examined the link between docosahexaenoic acid (DHA) and stroke incidence through a two-sample mendelian randomization analysis. The study utilized genome-wide association studies to uncover causal relationships at a genetic level.
Our findings indicated that higher levels of DHA are associated with a significantly lower risk of strokes. Specifically, we observed a negative correlation, with an odds ratio of 0.800, suggesting that as DHA levels increase, the likelihood of experiencing a stroke decreases.
This evidence highlights the potential protective effect of DHA against stroke, providing important insights into dietary recommendations and therapeutic targets for reducing stroke risk. It's especially noteworthy that our results showed consistency without signs of heterogeneity, reinforcing the reliability of these findings.
Our findings indicated that higher levels of DHA are associated with a significantly lower risk of strokes. Specifically, we observed a negative correlation, with an odds ratio of 0.800, suggesting that as DHA levels increase, the likelihood of experiencing a stroke decreases.
This evidence highlights the potential protective effect of DHA against stroke, providing important insights into dietary recommendations and therapeutic targets for reducing stroke risk. It's especially noteworthy that our results showed consistency without signs of heterogeneity, reinforcing the reliability of these findings.
Read More
9
DHA linked to reduced stroke risk
Omega-3 Fatty Acids and Risk of Ischemic Stroke in REGARDS.
Moderate relevance due to dietary factors
We examined the relationship between docosahexaenoic acid (DHA)—a type of omega-3 fatty acid—and the risk of experiencing an ischemic stroke. In our analysis, we utilized data from the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort, focusing on how various plasma lipids could influence stroke incidents.
Our study tracked participants for an average of seven years and involved 1,075 individuals who suffered an ischemic stroke compared to 968 who did not. We found that a specific lipid factor, rich in DHA, was linked to a lower risk of stroke. In our findings, individuals with higher levels of this lipid exhibited an impressive 16% reduction in stroke risk.
Moreover, we discovered that those who consumed a healthier diet, particularly with significant fish intake, had higher levels of DHA. The data showed that DHA played a key role in mediating the connection between fish consumption and stroke risk reduction. Since DHA-rich lipids were consistently associated with better health outcomes, this suggests that incorporating more omega-3 fatty acids into our diets could be beneficial in protecting against stroke.
Overall, our findings highlight the importance of DHA in potentially lowering the risk of ischemic stroke, encouraging a greater emphasis on dietary choices that enhance omega-3 intake.
Our study tracked participants for an average of seven years and involved 1,075 individuals who suffered an ischemic stroke compared to 968 who did not. We found that a specific lipid factor, rich in DHA, was linked to a lower risk of stroke. In our findings, individuals with higher levels of this lipid exhibited an impressive 16% reduction in stroke risk.
Moreover, we discovered that those who consumed a healthier diet, particularly with significant fish intake, had higher levels of DHA. The data showed that DHA played a key role in mediating the connection between fish consumption and stroke risk reduction. Since DHA-rich lipids were consistently associated with better health outcomes, this suggests that incorporating more omega-3 fatty acids into our diets could be beneficial in protecting against stroke.
Overall, our findings highlight the importance of DHA in potentially lowering the risk of ischemic stroke, encouraging a greater emphasis on dietary choices that enhance omega-3 intake.
Read More
9
DHA enhances stroke recovery efforts
Docosahexaenoic acid promotes M2 microglia phenotype via activating PPARγ-mediated ERK/AKT pathway against cerebral ischemia-reperfusion injury.
Direct investigation of DHA effects
We set out to explore the impact of docosahexaenoic acid (DHA) on strokes, particularly how it influences microglia—those essential cells in our brain that can either harm or heal after an injury.
In our study, we administered DHA to rats who had undergone an ischemia-reperfusion injury, a condition that simulates a stroke. Over three days, we observed significant changes in the brain's response. DHA not only improved overall brain health but also swayed microglia towards a protective, anti-inflammatory M2 phenotype rather than a damaging, inflammatory M1 state.
We noted that DHA reduced markers associated with the harmful M1 phenotype and boosted those linked to the beneficial M2 phenotype. Additionally, it activated pathways involving PPARγ that further moderated brain inflammation, which is crucial for recovery after a stroke.
Overall, the results suggest that DHA holds promise as a therapeutic strategy to aid recovery from strokes by promoting healthier microglial behavior and reducing harmful inflammation, paving the way for improved neurological outcomes.
In our study, we administered DHA to rats who had undergone an ischemia-reperfusion injury, a condition that simulates a stroke. Over three days, we observed significant changes in the brain's response. DHA not only improved overall brain health but also swayed microglia towards a protective, anti-inflammatory M2 phenotype rather than a damaging, inflammatory M1 state.
We noted that DHA reduced markers associated with the harmful M1 phenotype and boosted those linked to the beneficial M2 phenotype. Additionally, it activated pathways involving PPARγ that further moderated brain inflammation, which is crucial for recovery after a stroke.
Overall, the results suggest that DHA holds promise as a therapeutic strategy to aid recovery from strokes by promoting healthier microglial behavior and reducing harmful inflammation, paving the way for improved neurological outcomes.
Read More
9
Docosahexaenoic acid enhances stroke recovery
Selective ischemic-hemisphere targeting Ginkgolide B liposomes with improved solubility and therapeutic efficacy for cerebral ischemia-reperfusion injury.
Combination effect complicates assessment
We explored a unique approach to treating cerebral ischemia-reperfusion injury (CI/RI), a major factor in stroke-related disabilities and deaths. The focus of our investigation was the combination of Ginkgolide B (GB) with docosahexaenoic acid (DHA). Together, these compounds show promise in improving recovery after a stroke by addressing various physiological challenges.
The study reported that when GB was conjugated with DHA, the resulting compound was better able to cross the blood-brain barrier, a significant hurdle in drug delivery for stroke patients. We observed that this new combination was encapsulated in liposomes, enhancing both its solubility and stability.
During the research, we noted that this combined treatment significantly reduced the size of brain infarcts in stroke-affected rats and improved their recovery behaviors. DHA, alongside GB, appeared to lower levels of damaging reactive oxygen species and support neuron survival. Importantly, it also encouraged a shift in microglia, the brain's immune cells, from a harmful to a healing state, thereby reducing inflammation.
Overall, our findings highlight DHA's role, particularly in enhancing the therapeutic effects of GB for stroke recovery, suggesting its potential in future treatments for this debilitating condition.
The study reported that when GB was conjugated with DHA, the resulting compound was better able to cross the blood-brain barrier, a significant hurdle in drug delivery for stroke patients. We observed that this new combination was encapsulated in liposomes, enhancing both its solubility and stability.
During the research, we noted that this combined treatment significantly reduced the size of brain infarcts in stroke-affected rats and improved their recovery behaviors. DHA, alongside GB, appeared to lower levels of damaging reactive oxygen species and support neuron survival. Importantly, it also encouraged a shift in microglia, the brain's immune cells, from a harmful to a healing state, thereby reducing inflammation.
Overall, our findings highlight DHA's role, particularly in enhancing the therapeutic effects of GB for stroke recovery, suggesting its potential in future treatments for this debilitating condition.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.6
9.5
Stimulates recovery
This is a great supplement for the brain, particularly beneficial for schoolchildren and those recovering from a stroke, as it aids memory and concentration.
9.5
Supports rehabilitation
My mother took it for her rehabilitation after a stroke. I truly believe this supplement will aid her recovery. The quality is good, and I expect long-term health improvement.
9
Reduces stroke risk
DHA constitutes a significant part of brain fats, enhances vision, and improves memory. It possesses anti-inflammatory properties that can help during recovery from cardiovascular diseases and may reduce the risk of stroke. I recommend a minimum daily dosage of DHA for effective benefits.
Read More
8.8
Prevents stroke risk
DHA levels drop in the elderly, increasing the risk of memory loss. Supplementing with DHA promotes brain and eye development, reduces the risk of dementia, and may decrease stroke risk. A daily dose of 500–1,700 mg can enhance brain function and alleviate stress.
8.8
Improves health
DHA food supplement is of excellent quality. Each capsule contains Omega-3 fish oil and sufficient DHA. I've noticed better health and reduced risk of coronary heart disease and stroke. I take one capsule daily with meals.
