Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 18 Researches
8
USERS' SCORE
Good
Based on 7 Reviews
8.1
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Polyunsaturated Fat
1 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Docosahexaenoic Acid (DHA)
500 mg
†
Eicosapentaenoic Acid (EPA)
250 mg
†
Top Medical Research Studies
9
We aimed to find out whether docosahexaenoic acid (DHA) could offer protection against ischemic stroke in diabetic mice and better understand how it works. In our study, we administered DHA to diabetic mice after they experienced an ischemic stroke and evaluated their recovery over 24 hours and again at three days.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
Read More
9
We set out to explore the impact of docosahexaenoic acid (DHA) on strokes, particularly how it influences microglia—those essential cells in our brain that can either harm or heal after an injury.
In our study, we administered DHA to rats who had undergone an ischemia-reperfusion injury, a condition that simulates a stroke. Over three days, we observed significant changes in the brain's response. DHA not only improved overall brain health but also swayed microglia towards a protective, anti-inflammatory M2 phenotype rather than a damaging, inflammatory M1 state.
We noted that DHA reduced markers associated with the harmful M1 phenotype and boosted those linked to the beneficial M2 phenotype. Additionally, it activated pathways involving PPARγ that further moderated brain inflammation, which is crucial for recovery after a stroke.
Overall, the results suggest that DHA holds promise as a therapeutic strategy to aid recovery from strokes by promoting healthier microglial behavior and reducing harmful inflammation, paving the way for improved neurological outcomes.
In our study, we administered DHA to rats who had undergone an ischemia-reperfusion injury, a condition that simulates a stroke. Over three days, we observed significant changes in the brain's response. DHA not only improved overall brain health but also swayed microglia towards a protective, anti-inflammatory M2 phenotype rather than a damaging, inflammatory M1 state.
We noted that DHA reduced markers associated with the harmful M1 phenotype and boosted those linked to the beneficial M2 phenotype. Additionally, it activated pathways involving PPARγ that further moderated brain inflammation, which is crucial for recovery after a stroke.
Overall, the results suggest that DHA holds promise as a therapeutic strategy to aid recovery from strokes by promoting healthier microglial behavior and reducing harmful inflammation, paving the way for improved neurological outcomes.
Read More
9
We explored how docosahexaenoic acid, commonly known as DHA, helps protect the brain during ischaemic stroke. In this study, researchers created a mouse model of stroke using a method called middle cerebral artery occlusion. Additionally, they simulated stroke conditions in a type of brain cell known as PC12 cells through oxygen-glucose deprivation.
The findings were promising. DHA treatment significantly reduced brain infarction volume, decreased neuronal cell death, and improved behavioral recovery in mice. We observed that DHA promoted mitophagy, which is the body's way of clearing out damaged mitochondria. In neurons treated with DHA, there was a noticeable increase in autophagosomes and mitochondria that were actively involved in this cleaning process.
Moreover, DHA helped enhance the metabolism of glutamate and succinate in the neurons after stroke. Tests revealed that DHA effectively reduced harmful reactive oxygen species and improved mitochondrial health. This improvement was linked to increased levels of essential proteins involved in mitochondrial dynamics. When a specific inhibitor of mitophagy was introduced, the protective effects of DHA were reversed, showing that DHA’s benefits come largely from its role in enhancing mitophagy.
In summary, we found that DHA significantly protects against neuronal damage after stroke by promoting the removal of damaged mitochondria and improving mitochondrial function.
The findings were promising. DHA treatment significantly reduced brain infarction volume, decreased neuronal cell death, and improved behavioral recovery in mice. We observed that DHA promoted mitophagy, which is the body's way of clearing out damaged mitochondria. In neurons treated with DHA, there was a noticeable increase in autophagosomes and mitochondria that were actively involved in this cleaning process.
Moreover, DHA helped enhance the metabolism of glutamate and succinate in the neurons after stroke. Tests revealed that DHA effectively reduced harmful reactive oxygen species and improved mitochondrial health. This improvement was linked to increased levels of essential proteins involved in mitochondrial dynamics. When a specific inhibitor of mitophagy was introduced, the protective effects of DHA were reversed, showing that DHA’s benefits come largely from its role in enhancing mitophagy.
In summary, we found that DHA significantly protects against neuronal damage after stroke by promoting the removal of damaged mitochondria and improving mitochondrial function.
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Most Useful Reviews
9
Stimulates recovery
This is a great supplement for the brain, particularly beneficial for schoolchildren and those recovering from a stroke, as it aids memory and concentration.
Read More
6
Good for stroke
3 people found this helpful
Price-quality ratio is excellent. I choose a DHA supplement with 500 or 1,000 mg of DHA for brain and vision health. It also benefits the heart and blood vessels post-stroke. I use it consistently for three months or longer. If this review is helpful, please give a thumbs up.
Read More
7.5
Prevents stroke risk
1 people found this helpful
DHA levels drop in the elderly, increasing the risk of memory loss. Supplementing with DHA promotes brain and eye development, reduces the risk of dementia, and may decrease stroke risk. A daily dose of 500–1,700 mg can enhance brain function and alleviate stress.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 18 Researches
8
- All Researches
9
We aimed to find out whether docosahexaenoic acid (DHA) could offer protection against ischemic stroke in diabetic mice and better understand how it works. In our study, we administered DHA to diabetic mice after they experienced an ischemic stroke and evaluated their recovery over 24 hours and again at three days.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
Read More
9
We examined the link between docosahexaenoic acid (DHA) and stroke incidence through a two-sample mendelian randomization analysis. The study utilized genome-wide association studies to uncover causal relationships at a genetic level.
Our findings indicated that higher levels of DHA are associated with a significantly lower risk of strokes. Specifically, we observed a negative correlation, with an odds ratio of 0.800, suggesting that as DHA levels increase, the likelihood of experiencing a stroke decreases.
This evidence highlights the potential protective effect of DHA against stroke, providing important insights into dietary recommendations and therapeutic targets for reducing stroke risk. It's especially noteworthy that our results showed consistency without signs of heterogeneity, reinforcing the reliability of these findings.
Our findings indicated that higher levels of DHA are associated with a significantly lower risk of strokes. Specifically, we observed a negative correlation, with an odds ratio of 0.800, suggesting that as DHA levels increase, the likelihood of experiencing a stroke decreases.
This evidence highlights the potential protective effect of DHA against stroke, providing important insights into dietary recommendations and therapeutic targets for reducing stroke risk. It's especially noteworthy that our results showed consistency without signs of heterogeneity, reinforcing the reliability of these findings.
Read More
9
We examined the relationship between docosahexaenoic acid (DHA)—a type of omega-3 fatty acid—and the risk of experiencing an ischemic stroke. In our analysis, we utilized data from the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort, focusing on how various plasma lipids could influence stroke incidents.
Our study tracked participants for an average of seven years and involved 1,075 individuals who suffered an ischemic stroke compared to 968 who did not. We found that a specific lipid factor, rich in DHA, was linked to a lower risk of stroke. In our findings, individuals with higher levels of this lipid exhibited an impressive 16% reduction in stroke risk.
Moreover, we discovered that those who consumed a healthier diet, particularly with significant fish intake, had higher levels of DHA. The data showed that DHA played a key role in mediating the connection between fish consumption and stroke risk reduction. Since DHA-rich lipids were consistently associated with better health outcomes, this suggests that incorporating more omega-3 fatty acids into our diets could be beneficial in protecting against stroke.
Overall, our findings highlight the importance of DHA in potentially lowering the risk of ischemic stroke, encouraging a greater emphasis on dietary choices that enhance omega-3 intake.
Our study tracked participants for an average of seven years and involved 1,075 individuals who suffered an ischemic stroke compared to 968 who did not. We found that a specific lipid factor, rich in DHA, was linked to a lower risk of stroke. In our findings, individuals with higher levels of this lipid exhibited an impressive 16% reduction in stroke risk.
Moreover, we discovered that those who consumed a healthier diet, particularly with significant fish intake, had higher levels of DHA. The data showed that DHA played a key role in mediating the connection between fish consumption and stroke risk reduction. Since DHA-rich lipids were consistently associated with better health outcomes, this suggests that incorporating more omega-3 fatty acids into our diets could be beneficial in protecting against stroke.
Overall, our findings highlight the importance of DHA in potentially lowering the risk of ischemic stroke, encouraging a greater emphasis on dietary choices that enhance omega-3 intake.
Read More
9
We set out to explore the impact of docosahexaenoic acid (DHA) on strokes, particularly how it influences microglia—those essential cells in our brain that can either harm or heal after an injury.
In our study, we administered DHA to rats who had undergone an ischemia-reperfusion injury, a condition that simulates a stroke. Over three days, we observed significant changes in the brain's response. DHA not only improved overall brain health but also swayed microglia towards a protective, anti-inflammatory M2 phenotype rather than a damaging, inflammatory M1 state.
We noted that DHA reduced markers associated with the harmful M1 phenotype and boosted those linked to the beneficial M2 phenotype. Additionally, it activated pathways involving PPARγ that further moderated brain inflammation, which is crucial for recovery after a stroke.
Overall, the results suggest that DHA holds promise as a therapeutic strategy to aid recovery from strokes by promoting healthier microglial behavior and reducing harmful inflammation, paving the way for improved neurological outcomes.
In our study, we administered DHA to rats who had undergone an ischemia-reperfusion injury, a condition that simulates a stroke. Over three days, we observed significant changes in the brain's response. DHA not only improved overall brain health but also swayed microglia towards a protective, anti-inflammatory M2 phenotype rather than a damaging, inflammatory M1 state.
We noted that DHA reduced markers associated with the harmful M1 phenotype and boosted those linked to the beneficial M2 phenotype. Additionally, it activated pathways involving PPARγ that further moderated brain inflammation, which is crucial for recovery after a stroke.
Overall, the results suggest that DHA holds promise as a therapeutic strategy to aid recovery from strokes by promoting healthier microglial behavior and reducing harmful inflammation, paving the way for improved neurological outcomes.
Read More
9
Docosahexaenoic acid enhances stroke recovery
We explored a unique approach to treating cerebral ischemia-reperfusion injury (CI/RI), a major factor in stroke-related disabilities and deaths. The focus of our investigation was the combination of Ginkgolide B (GB) with docosahexaenoic acid (DHA). Together, these compounds show promise in improving recovery after a stroke by addressing various physiological challenges.
The study reported that when GB was conjugated with DHA, the resulting compound was better able to cross the blood-brain barrier, a significant hurdle in drug delivery for stroke patients. We observed that this new combination was encapsulated in liposomes, enhancing both its solubility and stability.
During the research, we noted that this combined treatment significantly reduced the size of brain infarcts in stroke-affected rats and improved their recovery behaviors. DHA, alongside GB, appeared to lower levels of damaging reactive oxygen species and support neuron survival. Importantly, it also encouraged a shift in microglia, the brain's immune cells, from a harmful to a healing state, thereby reducing inflammation.
Overall, our findings highlight DHA's role, particularly in enhancing the therapeutic effects of GB for stroke recovery, suggesting its potential in future treatments for this debilitating condition.
The study reported that when GB was conjugated with DHA, the resulting compound was better able to cross the blood-brain barrier, a significant hurdle in drug delivery for stroke patients. We observed that this new combination was encapsulated in liposomes, enhancing both its solubility and stability.
During the research, we noted that this combined treatment significantly reduced the size of brain infarcts in stroke-affected rats and improved their recovery behaviors. DHA, alongside GB, appeared to lower levels of damaging reactive oxygen species and support neuron survival. Importantly, it also encouraged a shift in microglia, the brain's immune cells, from a harmful to a healing state, thereby reducing inflammation.
Overall, our findings highlight DHA's role, particularly in enhancing the therapeutic effects of GB for stroke recovery, suggesting its potential in future treatments for this debilitating condition.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Stimulates recovery
This is a great supplement for the brain, particularly beneficial for schoolchildren and those recovering from a stroke, as it aids memory and concentration.
Read More
6
Good for stroke
3 people found this helpful
Price-quality ratio is excellent. I choose a DHA supplement with 500 or 1,000 mg of DHA for brain and vision health. It also benefits the heart and blood vessels post-stroke. I use it consistently for three months or longer. If this review is helpful, please give a thumbs up.
Read More
7.5
Prevents stroke risk
1 people found this helpful
DHA levels drop in the elderly, increasing the risk of memory loss. Supplementing with DHA promotes brain and eye development, reduces the risk of dementia, and may decrease stroke risk. A daily dose of 500–1,700 mg can enhance brain function and alleviate stress.
Read More
9
Supports rehabilitation
My mother took it for her rehabilitation after a stroke. I truly believe this supplement will aid her recovery. The quality is good, and I expect long-term health improvement.
Read More
8
Reduces stroke risk
DHA constitutes a significant part of brain fats, enhances vision, and improves memory. It possesses anti-inflammatory properties that can help during recovery from cardiovascular diseases and may reduce the risk of stroke. I recommend a minimum daily dosage of DHA for effective benefits.
Read More
Frequently Asked Questions
6
Good for stroke
3 people found this helpful
Price-quality ratio is excellent. I choose a DHA supplement with 500 or 1,000 mg of DHA for brain and vision health. It also benefits the heart and blood vessels post-stroke. I use it consistently for three months or longer. If this review is helpful, please give a thumbs up.
9
Supports rehabilitation
My mother took it for her rehabilitation after a stroke. I truly believe this supplement will aid her recovery. The quality is good, and I expect long-term health improvement.
9
Stimulates recovery
This is a great supplement for the brain, particularly beneficial for schoolchildren and those recovering from a stroke, as it aids memory and concentration.
7.5
Excellent value
I find the price and quality ratio outstanding. I take a DHA supplement of either 500 or 1,000 mg, which I believe is beneficial for my brain and heart health after a stroke. I intend to use it continuously, ideally for three months.
7.5
Prevents stroke risk
1 people found this helpful
DHA levels drop in the elderly, increasing the risk of memory loss. Supplementing with DHA promotes brain and eye development, reduces the risk of dementia, and may decrease stroke risk. A daily dose of 500–1,700 mg can enhance brain function and alleviate stress.
8
Reduces stroke risk
DHA constitutes a significant part of brain fats, enhances vision, and improves memory. It possesses anti-inflammatory properties that can help during recovery from cardiovascular diseases and may reduce the risk of stroke. I recommend a minimum daily dosage of DHA for effective benefits.
9
We aimed to find out whether docosahexaenoic acid (DHA) could offer protection against ischemic stroke in diabetic mice and better understand how it works. In our study, we administered DHA to diabetic mice after they experienced an ischemic stroke and evaluated their recovery over 24 hours and again at three days.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
8
We investigated how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, affects the risk of stroke in a large group of participants from various cohorts. Analyzing data from nearly 183,300 individuals over a median follow-up of 14.3 years, we focused on the relationship between circulating levels of DHA and different types of strokes: total, ischemic, and hemorrhagic.
Our findings indicated that higher levels of DHA were associated with a significant reduction in the risk of total and ischemic strokes. Specifically, individuals with the highest DHA levels experienced a 12% lower incidence of total strokes and a 14% lower incidence of ischemic strokes compared to those with the lowest levels.
It's important to note, however, that DHA did not show any association with hemorrhagic strokes. These results suggest that while increasing DHA intake may be beneficial for reducing certain types of stroke risk, it does not appear to influence the risk of hemorrhagic strokes. Overall, this study offers valuable insights into the potential protective role of DHA in stroke prevention.
Our findings indicated that higher levels of DHA were associated with a significant reduction in the risk of total and ischemic strokes. Specifically, individuals with the highest DHA levels experienced a 12% lower incidence of total strokes and a 14% lower incidence of ischemic strokes compared to those with the lowest levels.
It's important to note, however, that DHA did not show any association with hemorrhagic strokes. These results suggest that while increasing DHA intake may be beneficial for reducing certain types of stroke risk, it does not appear to influence the risk of hemorrhagic strokes. Overall, this study offers valuable insights into the potential protective role of DHA in stroke prevention.
8
We examined the potential of docosahexaenoic acid (DHA) in a unique treatment approach for ischemic stroke patients. The study developed a specialized hydrogel soft scaffold that releases DHA, combined with other growth factors, to create a supportive environment for healing brain tissue after a stroke.
The scaffold was designed to respond to reactive oxygen species, which are elevated in stroke conditions. This triggers the release of protective substances to counteract oxidative stress, paving the way for improved cell survival. Additionally, DHA is known for its role in reducing inflammation and promoting the growth of new neurons—key factors in brain recovery.
Our results showed that this DHA-enriched hydrogel significantly influenced the environment in the affected brain areas. In laboratory tests, it successfully reduced cell death and boosted new blood vessel formation. In mice models, we noted improved movement and behavioral functions over time, suggesting that this treatment could support natural healing processes after a stroke.
Overall, the study reveals that incorporating DHA into stroke treatment via innovative hydrogel delivery could enhance recovery by fostering a pro-regenerative atmosphere in the brain.
The scaffold was designed to respond to reactive oxygen species, which are elevated in stroke conditions. This triggers the release of protective substances to counteract oxidative stress, paving the way for improved cell survival. Additionally, DHA is known for its role in reducing inflammation and promoting the growth of new neurons—key factors in brain recovery.
Our results showed that this DHA-enriched hydrogel significantly influenced the environment in the affected brain areas. In laboratory tests, it successfully reduced cell death and boosted new blood vessel formation. In mice models, we noted improved movement and behavioral functions over time, suggesting that this treatment could support natural healing processes after a stroke.
Overall, the study reveals that incorporating DHA into stroke treatment via innovative hydrogel delivery could enhance recovery by fostering a pro-regenerative atmosphere in the brain.
8
Docosahexaenoic acid and stroke risk
We investigated how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, affects the risk of stroke. An extensive analysis was conducted on data from large cohort studies, which included thousands of participants without prior vascular disease. It's interesting to note that higher levels of n-3 polyunsaturated fatty acids (PUFAs), including DHA, were linked with a lower incidence of coronary heart disease and potentially stroke risk.
Specifically, our findings indicated that higher total n-3 PUFA levels correlated with a reduced risk of incident stroke. We observed that DHA on its own had a similar negative association regarding stroke risk. However, it's worth mentioning that while DHA appeared beneficial, the connection wasn't strong enough to establish it as a standalone treatment recommendation yet.
Ultimately, our findings suggest that while DHA could be a part of an overall healthy diet that supports cardiovascular health, more research is needed to deeply understand its role. This includes more randomized controlled trials to clarify the implications of DHA for stroke prevention.
Specifically, our findings indicated that higher total n-3 PUFA levels correlated with a reduced risk of incident stroke. We observed that DHA on its own had a similar negative association regarding stroke risk. However, it's worth mentioning that while DHA appeared beneficial, the connection wasn't strong enough to establish it as a standalone treatment recommendation yet.
Ultimately, our findings suggest that while DHA could be a part of an overall healthy diet that supports cardiovascular health, more research is needed to deeply understand its role. This includes more randomized controlled trials to clarify the implications of DHA for stroke prevention.
References
- Zhang W, Liu Y, Wu Y, Wang Z, Liu X, et al. ROS-triggered biomimetic hydrogel soft scaffold for ischemic stroke repair. Biomaterials. 2025;319:123217. 10.1016/j.biomaterials.2025.123217
- Liu C, Guo J, Guan L, Li C, Hu X, et al. Docosahexaenoic acid protects against ischemic stroke in diabetic mice by inhibiting inflammatory responses and apoptosis. Exp Neurol. 2025;385:115075. 10.1016/j.expneurol.2024.115075
- Shi F, Chowdhury R, Sofianopoulou E, Koulman A, Sun L, et al. Association of circulating fatty acids with cardiovascular disease risk: analysis of individual-level data in three large prospective cohorts and updated meta-analysis. Eur J Prev Cardiol. 2025;32:233. 10.1093/eurjpc/zwae315
- Wang Y, Yang B, Wang C. The association between fatty acids and atherosclerotic diseases: A mendelian randomization study. Clin Nutr ESPEN. 2024;63:447. 10.1016/j.clnesp.2024.06.018
- Ament Z, Patki A, Bhave VM, Kijpaisalratana N, Jones AC, et al. Omega-3 Fatty Acids and Risk of Ischemic Stroke in REGARDS. Transl Stroke Res. 2024. 10.1007/s12975-024-01256-7
- O'Keefe JH, Tintle NL, Harris WS, O'Keefe EL, Sala-Vila A, et al. Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies. Stroke. 2024;55:50. 10.1161/STROKEAHA.123.044281
- Kong J, Zou R, Chu R, Hu N, Liu J, et al. An Ultrasmall Cu/CuO Nanoparticle-Based Diselenide-Bridged Nanoplatform Mediating Reactive Oxygen Species Scavenging and Neuronal Membrane Enhancement for Targeted Therapy of Ischemic Stroke. ACS Nano. 2024;18:4140. 10.1021/acsnano.3c08734
- Lv H, Jia S, Sun Y, Pang M, Lv E, et al. Docosahexaenoic acid promotes M2 microglia phenotype via activating PPARγ-mediated ERK/AKT pathway against cerebral ischemia-reperfusion injury. Brain Res Bull. 2023;199:110660. 10.1016/j.brainresbull.2023.110660
- Yamagata K. Docosahexaenoic acid inhibits ischemic stroke to reduce vascular dementia and Alzheimer's disease. Prostaglandins Other Lipid Mediat. 2023;167:106733. 10.1016/j.prostaglandins.2023.106733
- Li Y, Zhang M, Li S, Zhang L, Kim J, et al. Selective ischemic-hemisphere targeting Ginkgolide B liposomes with improved solubility and therapeutic efficacy for cerebral ischemia-reperfusion injury. Asian J Pharm Sci. 2023;18:100783. 10.1016/j.ajps.2023.100783
- Sun E, Zhang J, Deng Y, Wang J, Wu Q, et al. Docosahexaenoic Acid Alleviates Brain Damage by Promoting Mitophagy in Mice with Ischaemic Stroke. Oxid Med Cell Longev. 2022;2022:3119649. 10.1155/2022/3119649
- Aggarwal R, Bhatt DL, Steg PG, Miller M, Brinton EA, et al. Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial. J Am Heart Assoc. 2025;14:e038656. 10.1161/JAHA.124.038656
- Liu Y, Wang W, Cui X, Lyu J, Xie Y. Exploring Genetic Associations of 3 Types of Risk Factors With Ischemic Stroke: An Integrated Bioinformatics Study. Stroke. 2024;55:1619. 10.1161/STROKEAHA.123.044424
- Olshansky B, Bhatt DL, Miller M, Steg PG, Brinton EA, et al. Cardiovascular Benefits of Icosapent Ethyl in Patients With and Without Atrial Fibrillation in REDUCE-IT. J Am Heart Assoc. 2023;12:e026756. 10.1161/JAHA.121.026756
- Bork CS, Lundbye-Christensen S, Venø SK, Lasota AN, Tjønneland A, et al. Intake of marine and plant-derived n-3 fatty acids and development of atherosclerotic cardiovascular disease in the Danish Diet, Cancer and Health cohort. Eur J Nutr. 2023;62:1389. 10.1007/s00394-022-03081-w
- Suzuki K, Sato H, Mori H, Matsumoto R, Arimoto Y, et al. Early Enteral Nutrition with High-Protein Whey Peptide Digestive Nutrients May Improve Prognosis in Subarachnoid Hemorrhage Patients. Medicina (Kaunas). 2022;58. 10.3390/medicina58091264
- Andone S, Farczádi L, Imre S, Bălașa R. Fatty Acids and Lipid Paradox-Neuroprotective Biomarkers in Ischemic Stroke. Int J Mol Sci. 2022;23. 10.3390/ijms231810810
- Yokoyama Y, Kuno T, Morita SX, Slipczuk L, Takagi H, et al. Eicosapentaenoic Acid for Cardiovascular Events Reduction- Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. J Cardiol. 2022;80:416. 10.1016/j.jjcc.2022.07.008
