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Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Iron (as iron bisglycinate chelate†)
25 mg
139%
The product is found useful for the following medical conditions
Anemia details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
USERS' SCORE
Excellent
Based on 314 Reviews
9.1
9.5
Iron treatment reduces anemia
Iron deficiency and anemia in pregnancy: a call to action!: -"If you don't take a temperature, you can't find a fever".
Most Relevant Research
We examined how iron treatment specifically impacts anemia, particularly during pregnancy. Iron deficiency is a leading cause of anemia, and finding the right treatment is crucial for both mothers and their developing babies.
Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.
However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.
However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
9.5
Saved from anemia
Most Useful Review
Solgar's iron supplement was a lifesaver for my severe anemia. I was barely able to function, feeling exhausted and memory impaired. After months of taking various iron pills, I finally overcame anemia. Doctors advised me to continue taking iron after each menstrual cycle due to my significant blood loss. I can't pinpoint any drawbacks to this supplement; it has solely beneficial effects.
Allergies details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 15 Reviews
8.9
8
Allergy management in iron treatments
From diagnosis to desensitization in immediate hypersensitivity reactions to both oral and parenteral iron salts.
Most Relevant Research
We examined the rise of hypersensitivity reactions (HRs) linked to iron agents, especially as their usage in treating iron deficiency has increased. In this study, we evaluated the clinical features of patients who experienced immediate hypersensitivity reactions (IHRs) to both oral and intravenous (IV) iron preparations.
Our analysis included the medical records of 96 patients with a history of these reactions. Among them, 47 had reactions to oral iron, while 49 reacted to IV iron. We conducted skin-prick tests with various iron salts, but found that these tests weren't very helpful for diagnosing IHRs. In fact, only a small percentage showed a positive reaction.
Interestingly, we noted that patients who were sensitive to IV iron experienced more severe reactions, including cases of anaphylaxis. Despite the challenges in diagnosing these allergies, we successfully conducted desensitization treatments for 15 patients needing iron, specifically using ferric carboxymaltose. This approach proved to be safe and effective, marking an important option for patients requiring iron therapy despite their hypersensitivity.
Our analysis included the medical records of 96 patients with a history of these reactions. Among them, 47 had reactions to oral iron, while 49 reacted to IV iron. We conducted skin-prick tests with various iron salts, but found that these tests weren't very helpful for diagnosing IHRs. In fact, only a small percentage showed a positive reaction.
Interestingly, we noted that patients who were sensitive to IV iron experienced more severe reactions, including cases of anaphylaxis. Despite the challenges in diagnosing these allergies, we successfully conducted desensitization treatments for 15 patients needing iron, specifically using ferric carboxymaltose. This approach proved to be safe and effective, marking an important option for patients requiring iron therapy despite their hypersensitivity.
9.5
No side effects
Most Useful Review
I took three large doses of two tablets daily for three months. My ferritin increased from 11 to 70. I experienced no issues with allergies or side effects, such as constipation. I've ordered another jar.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 95 Reviews
8.9
7
Iron boosts fatigue symptoms
The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT.
Most Relevant Research
We explored the effects of iron supplementation on individuals suffering from iron deficiency, specifically looking at its impact on symptoms like chronic fatigue syndrome (CFS). This was done through a well-structured study involving 176 blood donors who were iron deficient, with a randomized controlled trial design.
Participants were assigned to receive either intravenous iron or oral iron supplements. Over an 8-12 week period, we assessed changes in symptoms related to iron deficiency, including CFS, restless legs syndrome (RLS), sleeping disorders, and overall quality of life.
The results indicated that iron supplementation may significantly improve the symptoms associated with iron deficiency among blood donors. By addressing the iron deficiency, we noted improvements not only in fatigue but also in wellbeing, confirming that targeted iron treatment can be beneficial for those struggling with chronic fatigue linked to low iron levels. This is an exciting finding for both clinicians and patients, shedding light on a relatively simple intervention that can enhance quality of life.
Participants were assigned to receive either intravenous iron or oral iron supplements. Over an 8-12 week period, we assessed changes in symptoms related to iron deficiency, including CFS, restless legs syndrome (RLS), sleeping disorders, and overall quality of life.
The results indicated that iron supplementation may significantly improve the symptoms associated with iron deficiency among blood donors. By addressing the iron deficiency, we noted improvements not only in fatigue but also in wellbeing, confirming that targeted iron treatment can be beneficial for those struggling with chronic fatigue linked to low iron levels. This is an exciting finding for both clinicians and patients, shedding light on a relatively simple intervention that can enhance quality of life.
9.5
Fatigue alleviated
Most Useful Review
Iron in an easily digestible form helped me significantly. By the third day, my daytime fatigue and drowsiness vanished. I was diagnosed with low iron levels through tests. After my doctor prescribed this form, which is highly absorbable, I took one capsule daily along with other vitamins. I felt genuinely cheerful once I began this iron.
Dizziness details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.8
USERS' SCORE
Good
Based on 95 Reviews
8.9
9
Effect of iron on dizziness relief
Critical iron deficiency anemia with record low hemoglobin: a case report.
Most Relevant Research
We studied the impact of iron treatment on dizziness experienced by a 42-year-old woman suffering from severe iron deficiency anemia due to menometrorrhagia. Throughout her hospital stay, she received blood transfusions and intravenous iron, which played a critical role in addressing her debilitating symptoms.
Remarkably, despite her initial critically low hemoglobin levels, she managed to remain hemodynamically stable. By the end of her treatment, her symptoms of fatigue and dizziness had resolved, allowing her to return to her normal activities before discharge. This case highlights an important connection between iron levels and dizziness, illustrating that replenishing iron can significantly alleviate dizzy spells linked to anemia.
Our findings underscore how crucial it is to address iron deficiency effectively, as it can prevent serious complications and improve overall quality of life for patients experiencing symptoms like dizziness.
Remarkably, despite her initial critically low hemoglobin levels, she managed to remain hemodynamically stable. By the end of her treatment, her symptoms of fatigue and dizziness had resolved, allowing her to return to her normal activities before discharge. This case highlights an important connection between iron levels and dizziness, illustrating that replenishing iron can significantly alleviate dizzy spells linked to anemia.
Our findings underscore how crucial it is to address iron deficiency effectively, as it can prevent serious complications and improve overall quality of life for patients experiencing symptoms like dizziness.
9.5
Dizziness subsided
Most Useful Review
This iron supplement is incredible! After suffering from anaemia and dizziness for years, I tried various treatments that only led to constipation. Following my doctor's recommendation, I took this easily digestible iron. Within a month, my haemoglobin levels rose, and the dizziness was gone. I'm continuing to take it.
Autoimmune Disorder details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 125 Reviews
8.8
8
Ferroportin regulates RA cell activity
Ferroportin inhibits the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via regulating ROS/PI3K/AKT signaling pathway.
Most Relevant Research
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
9.5
Improved health
Most Useful Review
I am alive! I have chronic anaemia and have tried various forms of iron. Oral iron often causes digestive issues, especially at high doses. Solgar is gentle and has had no side effects for me; I noticed a positive effect within three days. Remember: iron absorbs poorly with tea, coffee, and dairy. It’s best taken with vegetables, fruits, or protein. Health to you, Russians!
Constipation details
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
6
USERS' SCORE
Good
Based on 342 Reviews
8.8
7
Iron's minimal effect on constipation
Low-Dose Prophylactic Oral Iron Supplementation (Ferrous Fumarate, Ferrous Bisglycinate, and Ferrous Sulphate) in Pregnancy Is Not Associated With Clinically Significant Gastrointestinal Complaints: Results From Two Randomized Studies.
Most Relevant Research
We explored the effects of low-dose iron supplementation on gastrointestinal complaints, particularly constipation, in pregnant women. Conducting two randomized studies, we aimed to determine how different forms of iron—ferrous fumarate, ferrous bisglycinate, and ferrous sulphate—would affect the frequency of GI issues among healthy women throughout their pregnancy.
Through our investigations, we found that constipation was only significantly associated with higher doses of ferrous fumarate (80 mg/day). Interestingly, women taking lower doses of ferrous fumarate (20-60 mg/day) did not report more GI side effects, indicating that manageable doses of iron may be tolerated without significant worry about constipation.
Among the iron formulas tested, ferrous bisglycinate at 25 mg showed the best profile, resulting in fewer GI complaints overall compared to the others. In fact, it was linked to a lower incidence of black stools, which can often be associated with iron intake. Ultimately, we observed that while low-dose iron supplementation might incur some side effects, they are generally not severe enough to warrant a change in dosage or interruption of treatment.
Through our investigations, we found that constipation was only significantly associated with higher doses of ferrous fumarate (80 mg/day). Interestingly, women taking lower doses of ferrous fumarate (20-60 mg/day) did not report more GI side effects, indicating that manageable doses of iron may be tolerated without significant worry about constipation.
Among the iron formulas tested, ferrous bisglycinate at 25 mg showed the best profile, resulting in fewer GI complaints overall compared to the others. In fact, it was linked to a lower incidence of black stools, which can often be associated with iron intake. Ultimately, we observed that while low-dose iron supplementation might incur some side effects, they are generally not severe enough to warrant a change in dosage or interruption of treatment.
9.5
No constipation
Most Useful Review
I started taking it with vitamin C on an empty stomach and in the evening with lactoferrin before bed. It seems to positively impact my digestion and iron absorption. I feel cheery, with no fatigue, and my hair stopped falling out. There’s no metallic taste, no stomach pains, and importantly, no constipation. I find the capsules easy to swallow; just one a day has noticeable effects. I highly recommend it for health.
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7
USERS' SCORE
Good
Based on 21 Reviews
8.8
7
Iron's Impact on Pregnancy Mental Health
Associations between iron status and psychosocial wellbeing among pregnant women in Cape Coast, Ghana: a longitudinal study.
Most Relevant Research
We set out to explore the connection between iron levels and mental health in pregnant women, focusing on how iron treatment may influence depressive symptoms. Our study recruited participants in their first trimester and followed them through their second and third trimesters, assessing their iron status and psychosocial wellbeing along the way.
Findings revealed that improvements in ferritin levels during the first and second trimesters were associated with fewer depressive symptoms and a better overall quality of life. This suggests that boosting iron levels in early pregnancy could potentially benefit mental health. Moreover, we discovered that increases in hemoglobin were linked to reduced anxiety, particularly feelings of fear, highlighting another positive aspect of improved iron status.
However, the results were more mixed in the later stages of pregnancy. While improvements in transferrin saturation from the second to the third trimester were connected to greater anxiety and a decline in quality of life, the initial positive effects underline the importance of monitoring and managing iron levels throughout pregnancy.
Overall, our findings hint at a beneficial relationship between iron status and psychosocial wellbeing, particularly in early pregnancy. However, more extensive studies are needed to confirm these promising results and better understand the nuances of this connection.
Findings revealed that improvements in ferritin levels during the first and second trimesters were associated with fewer depressive symptoms and a better overall quality of life. This suggests that boosting iron levels in early pregnancy could potentially benefit mental health. Moreover, we discovered that increases in hemoglobin were linked to reduced anxiety, particularly feelings of fear, highlighting another positive aspect of improved iron status.
However, the results were more mixed in the later stages of pregnancy. While improvements in transferrin saturation from the second to the third trimester were connected to greater anxiety and a decline in quality of life, the initial positive effects underline the importance of monitoring and managing iron levels throughout pregnancy.
Overall, our findings hint at a beneficial relationship between iron status and psychosocial wellbeing, particularly in early pregnancy. However, more extensive studies are needed to confirm these promising results and better understand the nuances of this connection.
9.3
Improved mood
Most Useful Review
Iron bisglycinate is the best form for absorption. After months of use due to low ferritin levels, I haven't yet retested my blood but did notice an initial excitement followed by stability in mood. My menstrual blood loss has decreased. A reasonable psychiatrist will check ferritin levels in those with depression, as low ferritin can be a contributing factor.
Tinnitus details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.7
9.5
Tinnitus improvement
Most Useful Review
I liked it! After passing my tests, I began taking this supplement as my iron levels were low. These vitamins are effective and gentle, with no side effects like the taste of iron. Within a week, I felt much better, and my tinnitus reduced significantly. Subsequent tests confirmed my iron levels had normalised, and I continued to feel well.
Bone Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.6
9.5
Improved health
Most Useful Review
The best hardware! I discovered this iron supplement during my pregnancy due to my anaemia. After two months, my iron deficiency was rectified, and my health improved significantly, with bone pain and dizziness disappearing. It is a mild form of iron that does not cause diarrhoea or stomach pain. If this was helpful, please like it!
Heart Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7
USERS' SCORE
Good
Based on 4 Reviews
8.6
9
Iron treatment effects on heart
Ironing Out the Controversies Surrounding the Iron Deficiency Definition in Heart Failure.
Most Relevant Research
We investigated the role of iron treatment in managing heart disease, particularly its isolated effects. The research closely looked at how iron supplementation interacts with other therapies in patients with heart conditions.
Heart disease can often be complicated by iron deficiency, leading to questions about the potential benefits of treating this deficiency. Our findings revealed that while iron treatment showed some promise, its overall effectiveness on improving heart disease symptoms or outcomes appeared limited when considered in isolation.
Additionally, the study emphasized the importance of viewing iron treatment not as a standalone solution, but as part of a broader approach that includes other therapies. This nuanced understanding can help guide healthcare practices in treating heart disease patients more effectively.
Heart disease can often be complicated by iron deficiency, leading to questions about the potential benefits of treating this deficiency. Our findings revealed that while iron treatment showed some promise, its overall effectiveness on improving heart disease symptoms or outcomes appeared limited when considered in isolation.
Additionally, the study emphasized the importance of viewing iron treatment not as a standalone solution, but as part of a broader approach that includes other therapies. This nuanced understanding can help guide healthcare practices in treating heart disease patients more effectively.
9.5
Significant relief
Most Useful Review
After three days of taking this iron supplement, I felt a remarkable difference. For four years, I’ve struggled with a lack of oxygen, which traditional visits to cardiologists failed to address. Discovering this product provided such relief, like a weight was lifted from my lungs and heart! If you have similar symptoms, I recommend getting an iron test and considering this supplement, as it genuinely works.
Pneumonia details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Hemoglobin increase
Most Useful Review
A friend's daughter had pneumonia, and her hemoglobin dropped to 76. After using this supplement, it rose to 120 in three months.
Vertigo details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Iron treatment alleviates vertigo symptoms
Symptom panorama in upper secondary school students and symptoms related to iron deficiency. Screening with laboratory tests, questionnaire and interventional treatment with iron.
Most Relevant Research
Our study aimed to understand how iron deficiency impacts students' experiences, particularly focusing on symptoms like vertigo and dizziness. We set out to identify undiagnosed iron deficiency among first-grade students at an upper secondary school and evaluated changes in their symptoms and lab results after three months of iron supplementation.
Through our research, we found that 12% of the students had iron deficiency, and 61% exhibited some abnormal test results related to iron levels. Notably, we observed that symptoms of vertigo and dizziness were significantly more common in those with iron deficiency. After the students received iron supplementation, we recorded notable improvements: iron levels increased, transferrin levels decreased, and importantly, there was a marked reduction in symptoms, including vertigo, irritability, and depressive feelings.
Our findings convincingly highlight that iron supplementation can be beneficial in alleviating certain symptoms, specifically vertigo and dizziness, among students struggling with iron deficiency. This connection opens doors to addressing quality of life issues tied to iron levels among young individuals.
Through our research, we found that 12% of the students had iron deficiency, and 61% exhibited some abnormal test results related to iron levels. Notably, we observed that symptoms of vertigo and dizziness were significantly more common in those with iron deficiency. After the students received iron supplementation, we recorded notable improvements: iron levels increased, transferrin levels decreased, and importantly, there was a marked reduction in symptoms, including vertigo, irritability, and depressive feelings.
Our findings convincingly highlight that iron supplementation can be beneficial in alleviating certain symptoms, specifically vertigo and dizziness, among students struggling with iron deficiency. This connection opens doors to addressing quality of life issues tied to iron levels among young individuals.
8.3
Menstruation normalised
Most Useful Review
The first joy of taking dietary supplements was the normalisation of my menstruation. My blood pressure stabilised, my head stopped hurting, and I regained normal sleep patterns. I acted quickly, so my vertigo also ceased. There were no issues with brown teeth or gastrointestinal problems after starting this supplement.
Cancer details
SCIENTIFIC SCORE
Likely Very Effective
Based on 10 Researches
9
USERS' SCORE
Good
Based on 1 Review
8.6
9
SPIO improves lymph node detection
Use of superparamagnetic iron oxide for sentinel lymph node detection following neoadjuvant systemic therapy. A systematic review and meta-analysis.
Most Relevant Research
We explored the effectiveness of superparamagnetic iron oxide (SPIO) in detecting sentinel lymph nodes in breast cancer patients who had undergone neoadjuvant systemic therapy before surgery. This study included a systematic review of multiple databases and focused on comparing SPIO to the standard methods involving radioisotope and blue dye.
Our findings highlight that SPIO successfully identified sentinel lymph nodes in about 98.1% of cases, while the standard method achieved a detection rate of 94.6%. When examining the number of lymph nodes retrieved, SPIO demonstrated superior performance, with an average of 2.26 nodes detected compared to 1.86 with the conventional approach.
The overall quality of the studies reviewed was considered good, indicating that we can reliably say SPIO can be safely and effectively adopted in clinical practice for these patients. This suggests a promising alternative in medical settings, where identifying lymph nodes accurately is crucial for treatment planning.
Our findings highlight that SPIO successfully identified sentinel lymph nodes in about 98.1% of cases, while the standard method achieved a detection rate of 94.6%. When examining the number of lymph nodes retrieved, SPIO demonstrated superior performance, with an average of 2.26 nodes detected compared to 1.86 with the conventional approach.
The overall quality of the studies reviewed was considered good, indicating that we can reliably say SPIO can be safely and effectively adopted in clinical practice for these patients. This suggests a promising alternative in medical settings, where identifying lymph nodes accurately is crucial for treatment planning.
9.5
Iron level recovery
Most Useful Review
I ordered this for a cancer patient whose iron was depleted due to chemotherapy. We tried other kosher iron supplements without success until we switched to Solgar gentle iron. Her levels began to rise, and she no longer needs transfusions after taking it first thing in the morning with vitamin C.
Chemotherapy details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 1 Review
8.6
9
Iron enhances chemo effectiveness
Eriodictyol-cisplatin coated nanomedicine synergistically promote osteosarcoma cells ferroptosis and chemosensitivity.
Most Relevant Research
We explored the impact of iron on chemotherapy effectiveness, particularly in the treatment of osteosarcoma (OS). The study revealed promising insights into how combining iron with eriodictyol and cisplatin could promote ferroptosis—a form of regulated cell death that can improve the overall effectiveness of cancer therapies.
The researchers discovered that eriodictyol can curb a protein known as BACH1, which leads to reduced production of GPX4, a key player in protecting cells from ferroptosis. By diminishing GPX4 levels, this combination appears to push cancer cells towards ferroptosis more effectively.
Moreover, employing hollow mesoporous nanocubes to deliver eriodictyol and cisplatin seamlessly combines these agents to enhance cell death in OS. Through multiple mechanisms, including the depletion of protective molecules and the direct initiation of fatal processes in cancer cells, the nanocomplex showed impressive results in both lab tests and animal studies.
Importantly, the treatment demonstrated effectiveness without causing significant harm to other organs, hinting at its potential as a therapeutic strategy for OS patients in need of better treatment options.
The researchers discovered that eriodictyol can curb a protein known as BACH1, which leads to reduced production of GPX4, a key player in protecting cells from ferroptosis. By diminishing GPX4 levels, this combination appears to push cancer cells towards ferroptosis more effectively.
Moreover, employing hollow mesoporous nanocubes to deliver eriodictyol and cisplatin seamlessly combines these agents to enhance cell death in OS. Through multiple mechanisms, including the depletion of protective molecules and the direct initiation of fatal processes in cancer cells, the nanocomplex showed impressive results in both lab tests and animal studies.
Importantly, the treatment demonstrated effectiveness without causing significant harm to other organs, hinting at its potential as a therapeutic strategy for OS patients in need of better treatment options.
9.5
Iron levels improvement
Most Useful Review
This product provided great absorption when paired with vitamin C. It was ordered for a cancer patient whose iron was depleted due to chemotherapy. After trying other Kosher iron supplements without success, we switched to Solgar gentle iron. Her iron levels began to rise, and she no longer requires transfusions. She took it on an empty stomach with 1000mg of vitamin C.
Back Pain details
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Good
Based on 1 Review
8.5
9
HP alleviates iron-induced back pain
Inhibits Iron Overload-Induced Oxidative Stress through Activation of Signaling in a Rat Model of Lumbar Spinal Stenosis.
Most Relevant Research
We investigated how a substance called HP influences iron-related oxidative stress and its connection to back pain in a common condition known as lumbar spinal stenosis (LSS). LSS causes significant discomfort and disability, particularly for older adults, primarily due to hypertrophy of the ligamentum flavum, which can be exacerbated by oxidative stress stemming from imbalanced iron levels.
Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.
Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.
Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.
Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.
Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
8.8
Improved energy levels
Most Useful Review
After childbirth, my severe anaemia led me to take medication prescribed by the maternity hospital, especially as I struggled with back pain. I noticed my eyelids were often pale, and I experienced frequent dizziness. Thankfully, I now wake up feeling refreshed each morning. I regularly purchased the popular supplement, but I’ve since cancelled it. I take one capsule daily but plan to shift to one every two days.
Common Cold details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 13 Reviews
8.5
9.5
Increased energy
Most Useful Review
HEMOGLOBIN IS GOING UP IMMEDIATELY! This excellent drug, iron in the chelated form of bisglycinate, has effectively restored my ferritin and normalised my haemoglobin levels. I feel more energetic and no longer sluggish. It has no side effects, such as constipation. My mother was also satisfied with it.
Nausea details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 107 Reviews
8.5
9
Iron treatment eases nausea in pregnancy
Efficacy and Safety of Microsomal Ferric Pyrophosphate Supplement for Iron Deficiency Anemia in Pregnancy.
Most Relevant Research
We conducted a study to examine the effectiveness of a specific iron supplement, emulsified microsomal ferric pyrophosphate (EMFP), in treating iron deficiency anemia among pregnant women. Our focus was not only on improving hemoglobin levels but also on alleviating related symptoms, including nausea.
Within 30 days of starting treatment with EMFP, we observed significant increases in hemoglobin levels, alongside marked improvements in serum ferritin and iron levels. As nausea is a common complaint among pregnant women, we noted a decrease in various symptoms, including nausea, breathlessness, and dizziness, which contributed to a better quality of life for the participants.
Notably, treatment compliance was remarkably high at 99.5%, indicating that the participants were committed to managing their anemia effectively. Importantly, we did not encounter any severe side effects related to the treatment, suggesting a favorable safety profile.
Overall, our findings support the idea that iron treatment can help alleviate nausea and other discomforts related to iron deficiency anemia in pregnancy, positively impacting both mother and baby.
Within 30 days of starting treatment with EMFP, we observed significant increases in hemoglobin levels, alongside marked improvements in serum ferritin and iron levels. As nausea is a common complaint among pregnant women, we noted a decrease in various symptoms, including nausea, breathlessness, and dizziness, which contributed to a better quality of life for the participants.
Notably, treatment compliance was remarkably high at 99.5%, indicating that the participants were committed to managing their anemia effectively. Importantly, we did not encounter any severe side effects related to the treatment, suggesting a favorable safety profile.
Overall, our findings support the idea that iron treatment can help alleviate nausea and other discomforts related to iron deficiency anemia in pregnancy, positively impacting both mother and baby.
9.5
No nausea experienced
Most Useful Review
I have dealt with iron deficiency anaemia my entire adult life. I usually maintain my iron levels through diet but turned to Solgar's Gentle Iron when my haemoglobin fell to critical levels. It has low toxicity and is well-absorbed, unlike other supplements that upset my stomach. After taking it, my dizziness and darkening vision when standing quickly improved. I experienced no nausea or pain for five months. I recommend taking iron at night, avoiding food before and after, and combining it with vitamin C.
Diabetes details
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
6.3
USERS' SCORE
Good
Based on 1 Review
8.5
8
Serum ferritin levels affect GDM
The association between serum ferritin levels and the risk of gestational diabetes mellitus: a prospective cohort study.
Most Relevant Research
We conducted a comprehensive study involving over 10,000 pregnant women to explore how serum ferritin levels—the stored form of iron in our bodies—might influence the risk of gestational diabetes mellitus (GDM). Serum ferritin levels were measured during the first and second trimesters, and women were subsequently tested for GDM between 24 to 28 weeks of pregnancy.
Our findings revealed that serum ferritin levels do play a role in the risk of developing GDM. Specifically, we found that women with lower ferritin levels in the first trimester who experienced an increase in levels by the second trimester had a significantly higher risk for GDM. Likewise, those who maintained high ferritin levels throughout both trimesters also showed increased risk.
These results suggest that maintaining a balanced level of iron in the body during early pregnancy may help reduce the chances of developing GDM. While our study highlights the importance of iron metabolism, it does not focus exclusively on the effects of iron treatment, leaving some questions open about how targeted iron therapies might influence diabetes risk directly.
Overall, understanding the connection between iron metabolism and diabetes is crucial as it can guide preventative strategies for expectant mothers.
Our findings revealed that serum ferritin levels do play a role in the risk of developing GDM. Specifically, we found that women with lower ferritin levels in the first trimester who experienced an increase in levels by the second trimester had a significantly higher risk for GDM. Likewise, those who maintained high ferritin levels throughout both trimesters also showed increased risk.
These results suggest that maintaining a balanced level of iron in the body during early pregnancy may help reduce the chances of developing GDM. While our study highlights the importance of iron metabolism, it does not focus exclusively on the effects of iron treatment, leaving some questions open about how targeted iron therapies might influence diabetes risk directly.
Overall, understanding the connection between iron metabolism and diabetes is crucial as it can guide preventative strategies for expectant mothers.
8
Constipation relief
Most Useful Review
My doctor prescribed me new diabetes medication that caused severe constipation. I started with two capsules, but it wasn't as effective as I'd hoped. After reading that some take four capsules, I decided to increase my intake to three, which did the trick.
Cardiovascular Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 6 Reviews
8.4
7
Iron deficiency impacts heart failure
Impact of iron deficiency on congestion and postdischarge survival in patients recently hospitalised for decompensated heart failure: a multicentre, prospective, observational analysis of the FERIC-RO study.
Most Relevant Research
Our investigation focused on the impact of iron deficiency in patients with worsening chronic heart failure, seeking clarity on how it affects their condition and recovery. We enrolled 163 patients from multiple centers who were hospitalized for this serious health issue. By evaluating iron deficiency at discharge, we distinguished those affected by low iron levels and compared various health indicators between groups.
We discovered that over half of the patients, 54.6%, had iron deficiency. Those with lower iron were more likely to exhibit signs of congestion and were categorized into more advanced heart failure classes. Interestingly, their levels of NT-proBNP, a crucial marker associated with heart failure, were significantly higher upon admission and didn’t improve much during their hospital stay.
While we found that mortality rates within 30 days had no significant difference between patients with and without iron deficiency, a notable increase in deaths was observed at 90 days post-discharge for those with iron deficiency. This suggests that iron levels could potentially influence recovery, especially in the longer term.
In conclusion, patients dealing with both chronic heart failure and iron deficiency showed more unresolved symptoms and poorer outcomes post-discharge. These findings highlight the importance of monitoring iron levels in patients facing heart issues, paving the way for future studies into treatment effectiveness and potential benefits of iron therapies.
We discovered that over half of the patients, 54.6%, had iron deficiency. Those with lower iron were more likely to exhibit signs of congestion and were categorized into more advanced heart failure classes. Interestingly, their levels of NT-proBNP, a crucial marker associated with heart failure, were significantly higher upon admission and didn’t improve much during their hospital stay.
While we found that mortality rates within 30 days had no significant difference between patients with and without iron deficiency, a notable increase in deaths was observed at 90 days post-discharge for those with iron deficiency. This suggests that iron levels could potentially influence recovery, especially in the longer term.
In conclusion, patients dealing with both chronic heart failure and iron deficiency showed more unresolved symptoms and poorer outcomes post-discharge. These findings highlight the importance of monitoring iron levels in patients facing heart issues, paving the way for future studies into treatment effectiveness and potential benefits of iron therapies.
9.5
Gentle iron absorption
Most Useful Review
A friend's iron level fell significantly, but after three months of using this supplement, it improved from 85 to 125. We started with two capsules daily, then reduced the dose gradually. However, always investigate the reason behind low iron levels before treatment, as sometimes the body lowers iron intentionally due to health issues.
Lung Cancer details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.8
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
Aging, iron, and lung cancer connections
Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis.
Most Relevant Research
We explored how ageing affects lung cancer development, focusing on the role of iron homeostasis. Our research used aged mouse models and primary cells to demonstrate that ageing actually suppresses the initiation and growth of lung cancer. This happens because the cells that could potentially give rise to tumors lose their "stemness," or ability to self-renew and form new cells, over time.
A key finding was the role of the NUPR1 transcription factor and its target, lipocalin-2. Both of these proteins increase with ageing, leading to functional iron insufficiency in the cells. We discovered that by either disabling the NUPR1-lipocalin-2 pathway or adding iron back into aged cells, we could restore their stemness and boost their potential to cause tumors. Interestingly, in younger cells, disrupting this pathway could lead to harmful effects like ferroptosis, a form of cell death.
Our research also revealed that specific changes in DNA methylation related to ageing contribute to higher NUPR1 levels. This underscores a complex relationship where ageing facilitates a protective environment against certain types of cell death while promoting traits that suppress cancer. The findings have important implications for cancer prevention strategies, suggesting that efforts should be focused on younger individuals where most cancers begin.
A key finding was the role of the NUPR1 transcription factor and its target, lipocalin-2. Both of these proteins increase with ageing, leading to functional iron insufficiency in the cells. We discovered that by either disabling the NUPR1-lipocalin-2 pathway or adding iron back into aged cells, we could restore their stemness and boost their potential to cause tumors. Interestingly, in younger cells, disrupting this pathway could lead to harmful effects like ferroptosis, a form of cell death.
Our research also revealed that specific changes in DNA methylation related to ageing contribute to higher NUPR1 levels. This underscores a complex relationship where ageing facilitates a protective environment against certain types of cell death while promoting traits that suppress cancer. The findings have important implications for cancer prevention strategies, suggesting that efforts should be focused on younger individuals where most cancers begin.
8.8
Anemia improvement
Most Useful Review
Anemia improved after my mother, who had her oesophagus removed due to lung cancer, struggled for over three years. Despite trying domestic supplements and iron medications, nothing worked until I started this treatment. Following several months of regular health check-ups, her blood test results showed improvement. I advised others to drink it after meals to avoid stomach ache, and I've noticed a reduction in dizziness. I'm just disappointed it's out of stock now.
Brain Tumor details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.3
USERS' SCORE
Good
Based on 1 Review
8.3
9
Iron nanoparticle imaging efficacy
A subtype specific probe for targeted magnetic resonance imaging of M2 tumor-associated macrophages in brain tumors.
Most Relevant Research
We explored the potential of using a specific type of iron nanoparticle to target and image a distinct group of immune cells known as M2 tumor-associated macrophages (TAMs) in brain tumors. These M2 TAMs can promote tumor growth and understanding their behavior could offer insights for better cancer treatments.
In our research, we developed a unique magnetic resonance imaging (MRI) probe composed of ultrafine iron oxide nanoparticles, which are small enough to avoid non-specific action in the body. We included a special peptide that actively seeks out M2 TAMs, allowing us to visualize them more clearly in mouse models of glioblastoma, a common and aggressive type of brain cancer.
The results were promising. The targeted nanoparticles showed a significant increase in accumulation within the tumors compared to standard nanoparticle formulations. This means that the M2-specific MRI probe provided a noticeable contrast in imaging, helping us differentiate areas of interest in the brain tumor environment better than conventional methods.
By demonstrating how effectively these iron nanoparticles can target specific immune cells, our study lays the groundwork for future research surrounding their use in cancer diagnostics and possibly in therapy. This could lead to improved strategies for tracking and altering the tumor environment as cancer progresses.
In our research, we developed a unique magnetic resonance imaging (MRI) probe composed of ultrafine iron oxide nanoparticles, which are small enough to avoid non-specific action in the body. We included a special peptide that actively seeks out M2 TAMs, allowing us to visualize them more clearly in mouse models of glioblastoma, a common and aggressive type of brain cancer.
The results were promising. The targeted nanoparticles showed a significant increase in accumulation within the tumors compared to standard nanoparticle formulations. This means that the M2-specific MRI probe provided a noticeable contrast in imaging, helping us differentiate areas of interest in the brain tumor environment better than conventional methods.
By demonstrating how effectively these iron nanoparticles can target specific immune cells, our study lays the groundwork for future research surrounding their use in cancer diagnostics and possibly in therapy. This could lead to improved strategies for tracking and altering the tumor environment as cancer progresses.
6.3
Reduced symptoms
Most Useful Review
I developed restless legs syndrome (RLS) about 10 years ago and started taking it due to its relation to iron deficiency in the brain. My symptoms have since eased, but I haven't used it again as the lid was difficult to open, and I broke it.
Heart Attack details
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Good
Based on 6 Reviews
8.3
9
Macrophage EVs combat iron overload
Macrophage-derived extracellular vesicles represent a promising endogenous iron-chelating therapy for iron overload and cardiac injury in myocardial infarction.
Most Relevant Research
We delved into the connection between iron overload and its effects on heart function after a heart attack, also known as myocardial infarction (MI). Our research focused on utilizing macrophage-derived extracellular vesicles (EVs) as a natural therapy to help with excessive iron levels in the heart.
The downside of existing chemical iron chelators is that they often come with side effects, so we sought a safer and more effective solution. By isolating EVs from macrophages, we found that they serve as a biological chelator for iron. When we introduced these EVs to heart cells affected by low oxygen levels, they significantly reduced iron overload and minimized the oxidative stress linked to this excess iron.
Notably, these EVs work by harnessing a receptor called transferrin receptor (TfR), which helps them grab onto and remove the surplus protein-bound iron. In our observations, when the EVs lacked TfR, they were ineffective in protecting heart tissue. This shows that leveraging macrophage-derived EVs could offer a new approach in treating heart damage due to iron overload, especially after myocardial infarction.
The downside of existing chemical iron chelators is that they often come with side effects, so we sought a safer and more effective solution. By isolating EVs from macrophages, we found that they serve as a biological chelator for iron. When we introduced these EVs to heart cells affected by low oxygen levels, they significantly reduced iron overload and minimized the oxidative stress linked to this excess iron.
Notably, these EVs work by harnessing a receptor called transferrin receptor (TfR), which helps them grab onto and remove the surplus protein-bound iron. In our observations, when the EVs lacked TfR, they were ineffective in protecting heart tissue. This shows that leveraging macrophage-derived EVs could offer a new approach in treating heart damage due to iron overload, especially after myocardial infarction.
9.5
Significant relief
Most Useful Review
After three days of taking this iron supplement, I felt a remarkable improvement. I've struggled with a lack of oxygen sensation for four years, which visits to specialists could not resolve. I luckily discovered that iron deficiency could cause this feeling. Since starting the supplement, I’ve experienced a significant sense of relief, as if a weight has been lifted from my lungs and heart. I highly recommend checking iron levels for anyone feeling similarly.
Cold Sores details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 3 Reviews
8.2
9
Iron therapy reduces cold sore frequency
Response to replacement iron therapy in sideropenic individuals with recrudescent herpes labialis.
Most Relevant Research
We investigated how iron replacement therapy affects the occurrence of cold sores, also known as recurrent herpes labialis, in people with low iron levels, a condition known as sideropenia. In our study, ten patients with confirmed sideropenia and a history of cold sores took ferrous sulphate for three months.
Before starting the treatment, these individuals reported experiencing an average of 0.78 episodes of cold sores each month. After the iron therapy, this number significantly dropped to just 0.2 episodes monthly. Furthermore, we found that there was a noteworthy increase in serum ferritin levels, a marker indicative of iron status, after treatment.
The results suggest that iron therapy may play a significant role in reducing the frequency of cold sores for those affected by iron deficiency. These findings are intriguing and warrant further exploration into iron supplementation as a potential option for managing cold sores in individuals with low iron levels.
Before starting the treatment, these individuals reported experiencing an average of 0.78 episodes of cold sores each month. After the iron therapy, this number significantly dropped to just 0.2 episodes monthly. Furthermore, we found that there was a noteworthy increase in serum ferritin levels, a marker indicative of iron status, after treatment.
The results suggest that iron therapy may play a significant role in reducing the frequency of cold sores for those affected by iron deficiency. These findings are intriguing and warrant further exploration into iron supplementation as a potential option for managing cold sores in individuals with low iron levels.
9.5
Improved iron levels
Most Useful Review
I administered this iron supplement with my daughter, and after four months, her ferritin rose from 7.5 to 34, which stabilised. Initially, she experienced intestinal issues, but after adjusting the dosage, everything was fine, and iron levels normalised. Previously, low ferritin resulted in frequent colds. Hemoglobin was 135, so I find this drug very effective!
Irritable Bowel Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6.8
USERS' SCORE
Good
Based on 21 Reviews
8
4
Iron Supplementation and Gut Microbiota
The Impact of Low-Level Iron Supplements on the Faecal Microbiota of Irritable Bowel Syndrome and Healthy Donors Using In Vitro Batch Cultures.
Most Relevant Research
We explored how low-level iron supplementation impacts the gut microbiota in individuals with Irritable Bowel Syndrome (IBS) and in healthy donors. To do this, we conducted anaerobic, pH-controlled in vitro batch cultures using fecal samples from both groups, supplemented with various forms of iron, including ferrous sulphate, nanoparticulate iron, and pea ferritin.
Our findings revealed that IBS participants had distinct microbial profiles compared to their healthy counterparts. Interestingly, we observed that the different sources of iron we used did not have a negative effect on the overall microbial populations. Both pea ferritin and nanoparticulate iron showed similar outcomes, while ferrous sulphate appeared to enhance certain beneficial bacteria.
Additionally, we measured the production of metabolites and found that there was no harmful shift towards increased proteolysis. These results suggest that low doses of iron from the three sources tested are unlikely to be detrimental to the gut microbiota, giving us new insights into the potential for iron supplementation in managing gut health, especially for those with IBS.
This is the first time we've tested fermentation of pea ferritin, which adds an exciting dimension to our understanding of dietary iron sources and gut health.
Our findings revealed that IBS participants had distinct microbial profiles compared to their healthy counterparts. Interestingly, we observed that the different sources of iron we used did not have a negative effect on the overall microbial populations. Both pea ferritin and nanoparticulate iron showed similar outcomes, while ferrous sulphate appeared to enhance certain beneficial bacteria.
Additionally, we measured the production of metabolites and found that there was no harmful shift towards increased proteolysis. These results suggest that low doses of iron from the three sources tested are unlikely to be detrimental to the gut microbiota, giving us new insights into the potential for iron supplementation in managing gut health, especially for those with IBS.
This is the first time we've tested fermentation of pea ferritin, which adds an exciting dimension to our understanding of dietary iron sources and gut health.
9.5
Symptoms improved
Most Useful Review
Since starting this supplement, my symptoms of restless legs syndrome have significantly decreased. I originally stopped drinking due to discomfort, but after resuming this supplement, my symptoms improved within days. Now, I only take it a few times a week and I am very grateful for the relief.
Chest Pain details
SCIENTIFIC SCORE
Likely Very Effective
Based on 3 Researches
9.2
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.9
9
Endometrial cancer-induced angina case
An atypical presentation of endometrial cancer as angina secondary to critically low hemoglobin and iron deficiency associated pancytopenia: A case report.
Most Relevant Research
We explored the intriguing link between iron treatment and angina symptoms in a unique case involving a 46-year-old woman with endometrial cancer. This patient arrived in the emergency department with acute chest pain, yet her heart was healthy based on ECG results. Instead, we found that her chest pain was a result of critically low hemoglobin levels caused by severe iron deficiency anemia.
Over the past six months, the patient experienced prolonged and heavy menstruation, which contributed to her anemia. After administering six units of packed red blood cells and an iron infusion, we witnessed a remarkable turnaround. The chest pain resolved, and her blood counts improved significantly.
This case is particularly noteworthy for highlighting how essential it is for women experiencing chest pain to be evaluated for anemia. It serves as a crucial reminder that understanding a patient's gynecological history can shed light on their overall health and symptoms. The link between iron treatment and relief from chest pain underscores the importance of recognizing the systemic effects of anemia.
Over the past six months, the patient experienced prolonged and heavy menstruation, which contributed to her anemia. After administering six units of packed red blood cells and an iron infusion, we witnessed a remarkable turnaround. The chest pain resolved, and her blood counts improved significantly.
This case is particularly noteworthy for highlighting how essential it is for women experiencing chest pain to be evaluated for anemia. It serves as a crucial reminder that understanding a patient's gynecological history can shed light on their overall health and symptoms. The link between iron treatment and relief from chest pain underscores the importance of recognizing the systemic effects of anemia.
10
Pain-free improvement
Most Useful Review
Really works! My mother's haematocrit was desperately low. After using this iron, her levels rose significantly without pain. I ordered another jar for her just in case it declines again.
Headache details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 41 Reviews
7.8
9.5
Reduced headaches
Most Useful Review
I found relief from chronic anaemia after childbirth with this supplement. My ferritin levels rose, and I no longer suffer from headaches. This product also improved my menstruation and didn’t cause constipation. I take it with vitamin C each morning.
Liver Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.8
9
Rubiadin reduces liver iron overload
Rubiadin Mediates the Upregulation of Hepatic Hepcidin and Alleviates Iron Overload via BMP6/SMAD1/5/9-Signaling Pathway.
Most Relevant Research
We explored the effects of rubiadin, a beneficial compound derived from a Chinese herb, on iron metabolism and its implications for liver disease. Recognizing the challenges posed by iron overload diseases, we aimed to discover a safe approach to manage excessive iron accumulation in the body. Through experiments involving various analyses, we observed that rubiadin significantly downregulated proteins that are typically elevated in conditions of high iron, such as transferrin receptor 1 and ferroportin 1.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
9.5
Effective iron supplement
Most Useful Review
Due to my persistently low haemoglobin levels linked to liver disease, I require ongoing iron supplements. After trying various preparations, I find Solgar chelated iron to be one of the few that genuinely alleviates my iron deficiency. An advantage of Solgar's encapsulated form is that it does not cause gastrointestinal discomfort, thus I recommend opting for chelated iron capsules over tablets, as they are gentler on the system even though slightly pricier.
Sleep Apnea details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.8
8
Iron improves sleep apnea symptoms
Intravenous iron therapy improves the hypercapnic ventilatory response and sleep disordered breathing in chronic heart failure.
Most Relevant Research
We conducted a study to discover how intravenous iron therapy impacts sleep apnea in patients suffering from heart failure, anemia, and iron deficiency. Patients were randomly assigned to receive either ferric carboxymaltose or a placebo to assess changes in their sleep and respiratory function after treatment.
Our findings revealed that the intravenous iron treatment significantly improved the hypercapnic ventilatory response, which is the way our bodies react to increased carbon dioxide levels. We observed that, in particular, patients who received iron saw a notable reduction in their apneas and hypopneas—those moments when breathing stops or becomes shallow while asleep. Specifically, the apnoea-hypopnoea index dropped to an average of 12 events per hour with treatment, compared to 19 events per hour in the placebo group.
Furthermore, those who received iron also reported better overall symptoms and had improved physical capacity during exercise tests. This suggests that iron therapy not only helps with sleep-related breathing issues but may also boost oxygen delivery during physical activities.
Overall, our study supports the notion that iron therapy could play an important role in managing sleep apnea among patients with heart failure, providing them with enhanced breathing during sleep and better quality of life.
Our findings revealed that the intravenous iron treatment significantly improved the hypercapnic ventilatory response, which is the way our bodies react to increased carbon dioxide levels. We observed that, in particular, patients who received iron saw a notable reduction in their apneas and hypopneas—those moments when breathing stops or becomes shallow while asleep. Specifically, the apnoea-hypopnoea index dropped to an average of 12 events per hour with treatment, compared to 19 events per hour in the placebo group.
Furthermore, those who received iron also reported better overall symptoms and had improved physical capacity during exercise tests. This suggests that iron therapy not only helps with sleep-related breathing issues but may also boost oxygen delivery during physical activities.
Overall, our study supports the notion that iron therapy could play an important role in managing sleep apnea among patients with heart failure, providing them with enhanced breathing during sleep and better quality of life.
9
Improved sleep quality
Most Useful Review
The result is clear! I have iron deficiency and cannot tolerate pharmaceutical iron due to severe stomach pain and diarrhoea. My gynaecologist recommended this iron, and so far, it is well tolerated. The capsules have a metallic taste, but overall, I feel much better. I take two a day, and the tachycardia has stopped. I now sleep deeply and soundly, which has greatly improved my wellbeing.
Heartburn details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 29 Reviews
7.5
8.3
No heartburn
Most Useful Review
After two weeks of this iron supplement, I've experienced no side effects or heartburn, and it's easy to take.
Leg Cramps details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Moderately Good
Based on 21 Reviews
7.3
7
Iron treatment improves leg cramps
Iron deficiency associates with deterioration in several symptoms independently from hemoglobin level among chronic hemodialysis patients.
Most Relevant Research
We explored the effects of iron deficiency (ID) in patients on maintenance hemodialysis, especially regarding common symptoms like leg cramps. The study included 154 patients, all of whom had reached target hemoglobin levels, which means they were not anemic. This allowed us to focus on the impact of ID without the confounding factor of low hemoglobin.
Our findings revealed that patients with iron deficiency reported a higher severity of leg cramps compared to those without ID. Specifically, we observed that a low transferrin saturation (TSAT) level contributed significantly to the experience of pain during vascular access punctures and those annoying intradialytic leg cramps. Additionally, patients with lower ferritin levels faced more intense issues like severe fatigue and headaches during their dialysis sessions.
The results suggest that treating iron deficiency could potentially alleviate these critical symptoms, indicating that proactive iron supplementation may be beneficial for those undergoing maintenance dialysis. Addressing ID might not only improve hemoglobin levels but also enhance overall quality of life by reducing painful experiences like leg cramps.
Our findings revealed that patients with iron deficiency reported a higher severity of leg cramps compared to those without ID. Specifically, we observed that a low transferrin saturation (TSAT) level contributed significantly to the experience of pain during vascular access punctures and those annoying intradialytic leg cramps. Additionally, patients with lower ferritin levels faced more intense issues like severe fatigue and headaches during their dialysis sessions.
The results suggest that treating iron deficiency could potentially alleviate these critical symptoms, indicating that proactive iron supplementation may be beneficial for those undergoing maintenance dialysis. Addressing ID might not only improve hemoglobin levels but also enhance overall quality of life by reducing painful experiences like leg cramps.
9.5
Reduced symptoms
Most Useful Review
Since I started taking this, my symptoms of restless legs have greatly decreased. After struggling with it for years, I noticed almost no symptoms now. My legs would feel itchy at times, but after starting this supplement, my condition improved rapidly. I now only take it a few times a week to keep the symptoms at bay. I'm very grateful for this product.
Diarrhea details
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
6.7
USERS' SCORE
Moderately Good
Based on 58 Reviews
7.1
9
Iron enhances piglet gut health
Dietary Fe-Gly supplementation attenuates enterotoxigenic (ETEC)-induced inflammation response and intestinal barrier dysfunction in piglets.
Most Relevant Research
We explored how adding iron, specifically Fe-Gly, to piglets' diets could help combat diarrhea caused by enterotoxigenic E. coli (ETEC) infections. In our study, we administered 50 mg of Fe-Gly to weaned piglets that had been infected, monitoring their growth, diarrhea rates, and overall gut health.
We observed remarkable improvements in the piglets' growth performance, with increases in average daily feed intake and daily gain by over 30%. Most notably, the rate of diarrhea significantly decreased by 40%. Additionally, we found that this iron supplementation raised the levels of total iron binding capacity in piglet serum, suggesting better iron transport and utilization.
Beyond growth metrics, the addition of Fe-Gly also showed potential in alleviating intestinal damage incurred from the ETEC challenge. As a result, we conclude that Fe-Gly not only meets daily iron needs but also reduces the iron available for harmful gut bacteria, promoting better intestinal health in piglets suffering from infections.
We observed remarkable improvements in the piglets' growth performance, with increases in average daily feed intake and daily gain by over 30%. Most notably, the rate of diarrhea significantly decreased by 40%. Additionally, we found that this iron supplementation raised the levels of total iron binding capacity in piglet serum, suggesting better iron transport and utilization.
Beyond growth metrics, the addition of Fe-Gly also showed potential in alleviating intestinal damage incurred from the ETEC challenge. As a result, we conclude that Fe-Gly not only meets daily iron needs but also reduces the iron available for harmful gut bacteria, promoting better intestinal health in piglets suffering from infections.
9.5
No diarrhea experienced
Most Useful Review
The best iron I have ever used. I experienced no side effects, and my analysis showed everything was fine. I used to have low haemoglobin, but now all indicators, including iron, are normal. The usual iron caused constant diarrhoea, which I do not recall with this product.
Gastritis details
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.1
USERS' SCORE
Moderately Good
Based on 26 Reviews
7
9.5
Iron treatment impacts gastritis
Iron Pill-Induced Gastritis in a Pediatric Patient Taking Ferrous Sulfate Tablets.
Most Relevant Research
We examined a case involving an 11-year-old male who experienced adverse effects from taking oral ferrous sulfate tablets to treat iron deficiency anemia. Over two months of treatment, he developed gastritis, which was confirmed through histological analysis during an endoscopy.
The findings revealed iron deposits in the stomach lining, prompting a reassessment of his iron supplementation strategy. We switched him from tablets to a liquid form of iron, which seemed to be gentler on his system.
After four months, a repeat endoscopy indicated a remarkable improvement, with the histological signs of gastritis resolving. This case illustrates that while iron is necessary for treating anemia, the form in which it's administered can significantly impact side effects like gastritis.
The findings revealed iron deposits in the stomach lining, prompting a reassessment of his iron supplementation strategy. We switched him from tablets to a liquid form of iron, which seemed to be gentler on his system.
After four months, a repeat endoscopy indicated a remarkable improvement, with the histological signs of gastritis resolving. This case illustrates that while iron is necessary for treating anemia, the form in which it's administered can significantly impact side effects like gastritis.
9.5
Felt better
Most Useful Review
This iron supplement has been beneficial. I didn’t take tests initially, but I noticed improvements within a few weeks—less hair loss and overall better health. It does not irritate my gastritis as I take it after meals. It is cost-effective, lasting a long time, so I highly recommend it!
Blood Clot details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6.5
USERS' SCORE
Medium or Average
Based on 14 Reviews
6.5
9
ESA and iron enhance surgery outcomes
Use of preoperative erythropoietin-stimulating agents is associated with decreased thrombotic adverse events compared to red blood cell transfusion in surgical patients with anaemia.
Most Relevant Research
We aimed to understand how preoperative treatments like erythropoietin-stimulating agents (ESAs) and intravenous (IV) iron influence the risk of blood clots in surgical patients dealing with anaemia.
In our investigation, we found that patients who received ESAs—whether accompanied by IV iron or not—had lower risks of serious post-operative complications, including blood clots, compared to those who were given red blood cell transfusions. Specifically, those treated with ESAs without IV iron showed significant reductions in mortality and the occurrence of venous thromboembolic events.
Interestingly, when IV iron was combined with ESAs, it appeared to further enhance outcomes, notably improving survival rates. Our results suggest that combining these treatments might yield benefits for patients undergoing surgery, reflected in higher haemoglobin levels and fewer complications compared to traditional blood transfusions.
In our investigation, we found that patients who received ESAs—whether accompanied by IV iron or not—had lower risks of serious post-operative complications, including blood clots, compared to those who were given red blood cell transfusions. Specifically, those treated with ESAs without IV iron showed significant reductions in mortality and the occurrence of venous thromboembolic events.
Interestingly, when IV iron was combined with ESAs, it appeared to further enhance outcomes, notably improving survival rates. Our results suggest that combining these treatments might yield benefits for patients undergoing surgery, reflected in higher haemoglobin levels and fewer complications compared to traditional blood transfusions.
8.3
Symptoms alleviated
Most Useful Review
I was identified with anaemia and began treatment recently. I noticed that dizziness from the anaemia has disappeared. I'm looking forward to my next blood test, as I feel significantly better overall.
Pelvic Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Medium or Average
Based on 17 Reviews
6.2
9.5
Reduced pelvic pain
Most Useful Review
I suffered from menorrhagia due to uterine fibroids, taking iron and Chinese medicine, but stopped due to stomach pain, nausea, and constipation. I often experienced dizziness and vomiting during my periods. However, this iron supplement causes no stomach pain, making it comfortable, and I now wake up refreshed. I take one tablet daily before bed with vitamin C. I recommend it to those who’ve not felt the effects of other iron preparations.
Bloating details
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.4
USERS' SCORE
Medium or Average
Based on 26 Reviews
6
8
Iron treatment’s impact on bloating
Sucrosomial Iron Supplementation in Anemic Patients with Celiac Disease Not Tolerating Oral Ferrous Sulfate: A Prospective Study.
Most Relevant Research
We explored how iron supplementation impacts patients with celiac disease who suffer from iron deficiency anemia, particularly focusing on those unable to tolerate traditional iron sulfate. In this study, patients were divided into two groups: one receiving a new formulation called sucrosomial iron and the other taking iron sulfate.
After a 90-day follow-up, both groups showed significant improvements in hemoglobin levels and overall iron metrics. Interestingly, those taking sucrosomial iron experienced a marked reduction in abdominal symptoms like bloating and pain. They reported feeling a 33% increase in general well-being compared to 21% in the iron sulfate group.
This suggests sucrosomial iron could be a preferable option for individuals with celiac disease who struggle with gastrointestinal discomfort from standard iron treatments. Overall, while both forms of iron supplementation were effective, sucrosomial iron may ease some of the unpleasant side effects commonly associated with iron therapy.
After a 90-day follow-up, both groups showed significant improvements in hemoglobin levels and overall iron metrics. Interestingly, those taking sucrosomial iron experienced a marked reduction in abdominal symptoms like bloating and pain. They reported feeling a 33% increase in general well-being compared to 21% in the iron sulfate group.
This suggests sucrosomial iron could be a preferable option for individuals with celiac disease who struggle with gastrointestinal discomfort from standard iron treatments. Overall, while both forms of iron supplementation were effective, sucrosomial iron may ease some of the unpleasant side effects commonly associated with iron therapy.
9.5
Elevated haemoglobin
Most Useful Review
Really soft iron! It has significantly raised my haemoglobin levels without any bloating or gastrointestinal side effects, unlike the sulphate iron I used previously. I take one capsule twice daily with lemon water. After months, my haemoglobin rose from 114 to 144 units. However, raising ferritin took longer, so I included other vitamins for better absorption. Highly recommend this product for anyone with signs of anaemia!
