Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 18 Researches
8.1
USERS' SCORE
Good
Based on 10 Reviews
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Wild Caught Fish Oil Concentrate
1250 mg
†
Total Omega-3 Fatty Acids as TG
1055 mg
†
EPA (Eicosapentaenoic Acid)
690 mg
†
DHA (Docosahexaenoic Acid)
310 mg
†
Other Omega-3 Fatty Acids
55 mg
†
Top Medical Research Studies
9
We investigated the relationship between eicosapentaenoic acid (EPA) levels and stroke risk by pooling data from 29 international studies, involving over 183,000 participants. Our goal was to understand how circulating and tissue omega-3 fatty acid levels, specifically EPA, affect the occurrence of different types of stroke, including total, ischemic, and hemorrhagic strokes.
Our findings revealed that higher levels of EPA are linked to a lower risk of both total and ischemic strokes. For participants who had the highest levels of EPA, there was a 17% lower incidence of total strokes compared to those with the lowest levels, and an 18% reduction in ischemic strokes. This suggests that increasing EPA intake could be beneficial in reducing the risk of these stroke types.
However, it's important to note that EPA showed no significant relationship with hemorrhagic stroke risk. This indicates that while EPA may help prevent some stroke types, it does not appear to reduce the risk of bleeding strokes. These results were consistent across various demographics, regardless of whether participants had a history of atrial fibrillation or existing cardiovascular disease. Overall, our study presents strong evidence that EPA can be a valuable addition to dietary strategies aimed at reducing stroke risks.
Our findings revealed that higher levels of EPA are linked to a lower risk of both total and ischemic strokes. For participants who had the highest levels of EPA, there was a 17% lower incidence of total strokes compared to those with the lowest levels, and an 18% reduction in ischemic strokes. This suggests that increasing EPA intake could be beneficial in reducing the risk of these stroke types.
However, it's important to note that EPA showed no significant relationship with hemorrhagic stroke risk. This indicates that while EPA may help prevent some stroke types, it does not appear to reduce the risk of bleeding strokes. These results were consistent across various demographics, regardless of whether participants had a history of atrial fibrillation or existing cardiovascular disease. Overall, our study presents strong evidence that EPA can be a valuable addition to dietary strategies aimed at reducing stroke risks.
Read More
9
We aimed to find out whether docosahexaenoic acid (DHA) could offer protection against ischemic stroke in diabetic mice and better understand how it works. In our study, we administered DHA to diabetic mice after they experienced an ischemic stroke and evaluated their recovery over 24 hours and again at three days.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
Read More
9
We set out to explore the impact of docosahexaenoic acid (DHA) on strokes, particularly how it influences microglia—those essential cells in our brain that can either harm or heal after an injury.
In our study, we administered DHA to rats who had undergone an ischemia-reperfusion injury, a condition that simulates a stroke. Over three days, we observed significant changes in the brain's response. DHA not only improved overall brain health but also swayed microglia towards a protective, anti-inflammatory M2 phenotype rather than a damaging, inflammatory M1 state.
We noted that DHA reduced markers associated with the harmful M1 phenotype and boosted those linked to the beneficial M2 phenotype. Additionally, it activated pathways involving PPARγ that further moderated brain inflammation, which is crucial for recovery after a stroke.
Overall, the results suggest that DHA holds promise as a therapeutic strategy to aid recovery from strokes by promoting healthier microglial behavior and reducing harmful inflammation, paving the way for improved neurological outcomes.
In our study, we administered DHA to rats who had undergone an ischemia-reperfusion injury, a condition that simulates a stroke. Over three days, we observed significant changes in the brain's response. DHA not only improved overall brain health but also swayed microglia towards a protective, anti-inflammatory M2 phenotype rather than a damaging, inflammatory M1 state.
We noted that DHA reduced markers associated with the harmful M1 phenotype and boosted those linked to the beneficial M2 phenotype. Additionally, it activated pathways involving PPARγ that further moderated brain inflammation, which is crucial for recovery after a stroke.
Overall, the results suggest that DHA holds promise as a therapeutic strategy to aid recovery from strokes by promoting healthier microglial behavior and reducing harmful inflammation, paving the way for improved neurological outcomes.
Read More
Most Useful Reviews
9
Improves brain function
9 people found this helpful
Omega 3 from RS provides a high level of fatty acids per capsule, accelerating metabolism and lowering blood viscosity and blood pressure. It effectively reduces the risk of stroke and heart attacks and enhances brain function while boosting skin and hair conditions. I highly recommend it for its genuine results.
Read More
9
Excellent quality
6 people found this helpful
Omega-3 fatty acids benefit heart health by lowering triglycerides and blood pressure slightly, reducing blood clotting, and mitigating the risk of stroke and heart failure. I've found the quality to be excellent; one pill suffices, and I have ordered it twice now after six months of use.
Read More
9
Youth prolonging effects
1 people found this helpful
Best Omega 3! I’ve tried various fish oils, but SR® Omega-3 is superior in composition and absorption. Despite being large, the capsules are easy to swallow, and one daily dose suffices for Omega 3 needs. They don't leave an unpleasant aftertaste and help regulate blood pressure, reduce heart attack and stroke risks, and support skin health, beauty, and muscle building during sports.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 18 Researches
8.1
- All Researches
9
We investigated the relationship between eicosapentaenoic acid (EPA) levels and stroke risk by pooling data from 29 international studies, involving over 183,000 participants. Our goal was to understand how circulating and tissue omega-3 fatty acid levels, specifically EPA, affect the occurrence of different types of stroke, including total, ischemic, and hemorrhagic strokes.
Our findings revealed that higher levels of EPA are linked to a lower risk of both total and ischemic strokes. For participants who had the highest levels of EPA, there was a 17% lower incidence of total strokes compared to those with the lowest levels, and an 18% reduction in ischemic strokes. This suggests that increasing EPA intake could be beneficial in reducing the risk of these stroke types.
However, it's important to note that EPA showed no significant relationship with hemorrhagic stroke risk. This indicates that while EPA may help prevent some stroke types, it does not appear to reduce the risk of bleeding strokes. These results were consistent across various demographics, regardless of whether participants had a history of atrial fibrillation or existing cardiovascular disease. Overall, our study presents strong evidence that EPA can be a valuable addition to dietary strategies aimed at reducing stroke risks.
Our findings revealed that higher levels of EPA are linked to a lower risk of both total and ischemic strokes. For participants who had the highest levels of EPA, there was a 17% lower incidence of total strokes compared to those with the lowest levels, and an 18% reduction in ischemic strokes. This suggests that increasing EPA intake could be beneficial in reducing the risk of these stroke types.
However, it's important to note that EPA showed no significant relationship with hemorrhagic stroke risk. This indicates that while EPA may help prevent some stroke types, it does not appear to reduce the risk of bleeding strokes. These results were consistent across various demographics, regardless of whether participants had a history of atrial fibrillation or existing cardiovascular disease. Overall, our study presents strong evidence that EPA can be a valuable addition to dietary strategies aimed at reducing stroke risks.
Read More
9
We aimed to find out whether docosahexaenoic acid (DHA) could offer protection against ischemic stroke in diabetic mice and better understand how it works. In our study, we administered DHA to diabetic mice after they experienced an ischemic stroke and evaluated their recovery over 24 hours and again at three days.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
Read More
9
We examined the link between docosahexaenoic acid (DHA) and stroke incidence through a two-sample mendelian randomization analysis. The study utilized genome-wide association studies to uncover causal relationships at a genetic level.
Our findings indicated that higher levels of DHA are associated with a significantly lower risk of strokes. Specifically, we observed a negative correlation, with an odds ratio of 0.800, suggesting that as DHA levels increase, the likelihood of experiencing a stroke decreases.
This evidence highlights the potential protective effect of DHA against stroke, providing important insights into dietary recommendations and therapeutic targets for reducing stroke risk. It's especially noteworthy that our results showed consistency without signs of heterogeneity, reinforcing the reliability of these findings.
Our findings indicated that higher levels of DHA are associated with a significantly lower risk of strokes. Specifically, we observed a negative correlation, with an odds ratio of 0.800, suggesting that as DHA levels increase, the likelihood of experiencing a stroke decreases.
This evidence highlights the potential protective effect of DHA against stroke, providing important insights into dietary recommendations and therapeutic targets for reducing stroke risk. It's especially noteworthy that our results showed consistency without signs of heterogeneity, reinforcing the reliability of these findings.
Read More
9
We examined the relationship between docosahexaenoic acid (DHA)—a type of omega-3 fatty acid—and the risk of experiencing an ischemic stroke. In our analysis, we utilized data from the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort, focusing on how various plasma lipids could influence stroke incidents.
Our study tracked participants for an average of seven years and involved 1,075 individuals who suffered an ischemic stroke compared to 968 who did not. We found that a specific lipid factor, rich in DHA, was linked to a lower risk of stroke. In our findings, individuals with higher levels of this lipid exhibited an impressive 16% reduction in stroke risk.
Moreover, we discovered that those who consumed a healthier diet, particularly with significant fish intake, had higher levels of DHA. The data showed that DHA played a key role in mediating the connection between fish consumption and stroke risk reduction. Since DHA-rich lipids were consistently associated with better health outcomes, this suggests that incorporating more omega-3 fatty acids into our diets could be beneficial in protecting against stroke.
Overall, our findings highlight the importance of DHA in potentially lowering the risk of ischemic stroke, encouraging a greater emphasis on dietary choices that enhance omega-3 intake.
Our study tracked participants for an average of seven years and involved 1,075 individuals who suffered an ischemic stroke compared to 968 who did not. We found that a specific lipid factor, rich in DHA, was linked to a lower risk of stroke. In our findings, individuals with higher levels of this lipid exhibited an impressive 16% reduction in stroke risk.
Moreover, we discovered that those who consumed a healthier diet, particularly with significant fish intake, had higher levels of DHA. The data showed that DHA played a key role in mediating the connection between fish consumption and stroke risk reduction. Since DHA-rich lipids were consistently associated with better health outcomes, this suggests that incorporating more omega-3 fatty acids into our diets could be beneficial in protecting against stroke.
Overall, our findings highlight the importance of DHA in potentially lowering the risk of ischemic stroke, encouraging a greater emphasis on dietary choices that enhance omega-3 intake.
Read More
9
We set out to explore the impact of docosahexaenoic acid (DHA) on strokes, particularly how it influences microglia—those essential cells in our brain that can either harm or heal after an injury.
In our study, we administered DHA to rats who had undergone an ischemia-reperfusion injury, a condition that simulates a stroke. Over three days, we observed significant changes in the brain's response. DHA not only improved overall brain health but also swayed microglia towards a protective, anti-inflammatory M2 phenotype rather than a damaging, inflammatory M1 state.
We noted that DHA reduced markers associated with the harmful M1 phenotype and boosted those linked to the beneficial M2 phenotype. Additionally, it activated pathways involving PPARγ that further moderated brain inflammation, which is crucial for recovery after a stroke.
Overall, the results suggest that DHA holds promise as a therapeutic strategy to aid recovery from strokes by promoting healthier microglial behavior and reducing harmful inflammation, paving the way for improved neurological outcomes.
In our study, we administered DHA to rats who had undergone an ischemia-reperfusion injury, a condition that simulates a stroke. Over three days, we observed significant changes in the brain's response. DHA not only improved overall brain health but also swayed microglia towards a protective, anti-inflammatory M2 phenotype rather than a damaging, inflammatory M1 state.
We noted that DHA reduced markers associated with the harmful M1 phenotype and boosted those linked to the beneficial M2 phenotype. Additionally, it activated pathways involving PPARγ that further moderated brain inflammation, which is crucial for recovery after a stroke.
Overall, the results suggest that DHA holds promise as a therapeutic strategy to aid recovery from strokes by promoting healthier microglial behavior and reducing harmful inflammation, paving the way for improved neurological outcomes.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improves brain function
9 people found this helpful
Omega 3 from RS provides a high level of fatty acids per capsule, accelerating metabolism and lowering blood viscosity and blood pressure. It effectively reduces the risk of stroke and heart attacks and enhances brain function while boosting skin and hair conditions. I highly recommend it for its genuine results.
Read More
9
Excellent quality
6 people found this helpful
Omega-3 fatty acids benefit heart health by lowering triglycerides and blood pressure slightly, reducing blood clotting, and mitigating the risk of stroke and heart failure. I've found the quality to be excellent; one pill suffices, and I have ordered it twice now after six months of use.
Read More
9
Youth prolonging effects
1 people found this helpful
Best Omega 3! I’ve tried various fish oils, but SR® Omega-3 is superior in composition and absorption. Despite being large, the capsules are easy to swallow, and one daily dose suffices for Omega 3 needs. They don't leave an unpleasant aftertaste and help regulate blood pressure, reduce heart attack and stroke risks, and support skin health, beauty, and muscle building during sports.
Read More
7.5
Lowers stroke risk
1 people found this helpful
This high-quality Omega-3, made from natural fish oil, has an acceptable taste and a reasonable price compared to competitors. It helps to lower triglycerides and slightly reduce blood pressure, blood clotting, and the risk of stroke and heart failure. Additionally, it helps to manage inflammation and maintain brain health.
Read More
9
Anti-inflammatory properties
In clinical trials, Omega-3s have demonstrated the ability to regulate blood pressure and reduce blood clotting, thus decreasing the risk of heart attacks and strokes. Furthermore, Omega-3s lower triglycerides, cholesterol levels, and exhibit anti-inflammatory and antiarrhythmic properties.
Read More
Frequently Asked Questions
7.5
Enhanced recovery
This is the product I was seeking as a supplement for my husband after he experienced a mild stroke. Since consuming this fish oil, his body feels more comfortable, and his feet feel light when walking.
9
Doctor-recommended
My personal recommendation for after a stroke. My doctor advised a double dose of this Omega, and we clearly saw positive results from it.
9
Excellent quality
6 people found this helpful
Omega-3 fatty acids benefit heart health by lowering triglycerides and blood pressure slightly, reducing blood clotting, and mitigating the risk of stroke and heart failure. I've found the quality to be excellent; one pill suffices, and I have ordered it twice now after six months of use.
9
Supports cardiovascular system
Omega-3 acids contribute significantly to the cardiovascular system by lowering blood pressure, cholesterol levels, and reducing the risk of heart attack and stroke. They also slow skin aging, improve joint care, regulate inflammation, enhance memory and brain function, and support immune health while boosting blood circulation.
9
Improves brain function
9 people found this helpful
Omega 3 from RS provides a high level of fatty acids per capsule, accelerating metabolism and lowering blood viscosity and blood pressure. It effectively reduces the risk of stroke and heart attacks and enhances brain function while boosting skin and hair conditions. I highly recommend it for its genuine results.
7.5
Lowers stroke risk
1 people found this helpful
This high-quality Omega-3, made from natural fish oil, has an acceptable taste and a reasonable price compared to competitors. It helps to lower triglycerides and slightly reduce blood pressure, blood clotting, and the risk of stroke and heart failure. Additionally, it helps to manage inflammation and maintain brain health.
9
Anti-inflammatory properties
In clinical trials, Omega-3s have demonstrated the ability to regulate blood pressure and reduce blood clotting, thus decreasing the risk of heart attacks and strokes. Furthermore, Omega-3s lower triglycerides, cholesterol levels, and exhibit anti-inflammatory and antiarrhythmic properties.
9
Youth prolonging effects
1 people found this helpful
Best Omega 3! I’ve tried various fish oils, but SR® Omega-3 is superior in composition and absorption. Despite being large, the capsules are easy to swallow, and one daily dose suffices for Omega 3 needs. They don't leave an unpleasant aftertaste and help regulate blood pressure, reduce heart attack and stroke risks, and support skin health, beauty, and muscle building during sports.
9
We investigated the relationship between eicosapentaenoic acid (EPA) levels and stroke risk by pooling data from 29 international studies, involving over 183,000 participants. Our goal was to understand how circulating and tissue omega-3 fatty acid levels, specifically EPA, affect the occurrence of different types of stroke, including total, ischemic, and hemorrhagic strokes.
Our findings revealed that higher levels of EPA are linked to a lower risk of both total and ischemic strokes. For participants who had the highest levels of EPA, there was a 17% lower incidence of total strokes compared to those with the lowest levels, and an 18% reduction in ischemic strokes. This suggests that increasing EPA intake could be beneficial in reducing the risk of these stroke types.
However, it's important to note that EPA showed no significant relationship with hemorrhagic stroke risk. This indicates that while EPA may help prevent some stroke types, it does not appear to reduce the risk of bleeding strokes. These results were consistent across various demographics, regardless of whether participants had a history of atrial fibrillation or existing cardiovascular disease. Overall, our study presents strong evidence that EPA can be a valuable addition to dietary strategies aimed at reducing stroke risks.
Our findings revealed that higher levels of EPA are linked to a lower risk of both total and ischemic strokes. For participants who had the highest levels of EPA, there was a 17% lower incidence of total strokes compared to those with the lowest levels, and an 18% reduction in ischemic strokes. This suggests that increasing EPA intake could be beneficial in reducing the risk of these stroke types.
However, it's important to note that EPA showed no significant relationship with hemorrhagic stroke risk. This indicates that while EPA may help prevent some stroke types, it does not appear to reduce the risk of bleeding strokes. These results were consistent across various demographics, regardless of whether participants had a history of atrial fibrillation or existing cardiovascular disease. Overall, our study presents strong evidence that EPA can be a valuable addition to dietary strategies aimed at reducing stroke risks.
8
We explored the connection between eicosapentaenoic acid, a type of omega-3 fatty acid, and the risk of ischemic stroke (IS). The study utilized genetic analysis and data from various sources to determine if eicosapentaenoic acid directly affects stroke outcomes.
Our findings indicated that eicosapentaenoic acid was associated with an increased risk of IS, showing an odds ratio of 2.36. This suggests that higher levels of this fatty acid might correlate with a greater chance of experiencing a stroke.
However, it's important to note that while the results are interesting, they do not clearly establish eicosapentaenoic acid as a beneficial treatment for stroke prevention. Instead, they highlight a potential risk factor that requires further research.
We identified 73 genes associated with blood pressure and circulating lipids in the context of IS, emphasizing the complex interplay between genetics, nutrition, and stroke risk. This study helps advance our understanding of how dietary components may influence stroke dynamics, opening pathways for future investigations.
Our findings indicated that eicosapentaenoic acid was associated with an increased risk of IS, showing an odds ratio of 2.36. This suggests that higher levels of this fatty acid might correlate with a greater chance of experiencing a stroke.
However, it's important to note that while the results are interesting, they do not clearly establish eicosapentaenoic acid as a beneficial treatment for stroke prevention. Instead, they highlight a potential risk factor that requires further research.
We identified 73 genes associated with blood pressure and circulating lipids in the context of IS, emphasizing the complex interplay between genetics, nutrition, and stroke risk. This study helps advance our understanding of how dietary components may influence stroke dynamics, opening pathways for future investigations.
9
We examined the link between docosahexaenoic acid (DHA) and stroke incidence through a two-sample mendelian randomization analysis. The study utilized genome-wide association studies to uncover causal relationships at a genetic level.
Our findings indicated that higher levels of DHA are associated with a significantly lower risk of strokes. Specifically, we observed a negative correlation, with an odds ratio of 0.800, suggesting that as DHA levels increase, the likelihood of experiencing a stroke decreases.
This evidence highlights the potential protective effect of DHA against stroke, providing important insights into dietary recommendations and therapeutic targets for reducing stroke risk. It's especially noteworthy that our results showed consistency without signs of heterogeneity, reinforcing the reliability of these findings.
Our findings indicated that higher levels of DHA are associated with a significantly lower risk of strokes. Specifically, we observed a negative correlation, with an odds ratio of 0.800, suggesting that as DHA levels increase, the likelihood of experiencing a stroke decreases.
This evidence highlights the potential protective effect of DHA against stroke, providing important insights into dietary recommendations and therapeutic targets for reducing stroke risk. It's especially noteworthy that our results showed consistency without signs of heterogeneity, reinforcing the reliability of these findings.
9
We set out to explore the impact of docosahexaenoic acid (DHA) on strokes, particularly how it influences microglia—those essential cells in our brain that can either harm or heal after an injury.
In our study, we administered DHA to rats who had undergone an ischemia-reperfusion injury, a condition that simulates a stroke. Over three days, we observed significant changes in the brain's response. DHA not only improved overall brain health but also swayed microglia towards a protective, anti-inflammatory M2 phenotype rather than a damaging, inflammatory M1 state.
We noted that DHA reduced markers associated with the harmful M1 phenotype and boosted those linked to the beneficial M2 phenotype. Additionally, it activated pathways involving PPARγ that further moderated brain inflammation, which is crucial for recovery after a stroke.
Overall, the results suggest that DHA holds promise as a therapeutic strategy to aid recovery from strokes by promoting healthier microglial behavior and reducing harmful inflammation, paving the way for improved neurological outcomes.
In our study, we administered DHA to rats who had undergone an ischemia-reperfusion injury, a condition that simulates a stroke. Over three days, we observed significant changes in the brain's response. DHA not only improved overall brain health but also swayed microglia towards a protective, anti-inflammatory M2 phenotype rather than a damaging, inflammatory M1 state.
We noted that DHA reduced markers associated with the harmful M1 phenotype and boosted those linked to the beneficial M2 phenotype. Additionally, it activated pathways involving PPARγ that further moderated brain inflammation, which is crucial for recovery after a stroke.
Overall, the results suggest that DHA holds promise as a therapeutic strategy to aid recovery from strokes by promoting healthier microglial behavior and reducing harmful inflammation, paving the way for improved neurological outcomes.
References
- Aggarwal R, Bhatt DL, Steg PG, Miller M, Brinton EA, et al. Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial. J Am Heart Assoc. 2025;14:e038656. doi:10.1161/JAHA.124.038656
- Liu Y, Wang W, Cui X, Lyu J, Xie Y. Exploring Genetic Associations of 3 Types of Risk Factors With Ischemic Stroke: An Integrated Bioinformatics Study. Stroke. 2024;55:1619. doi:10.1161/STROKEAHA.123.044424
- O'Keefe JH, Tintle NL, Harris WS, O'Keefe EL, Sala-Vila A, et al. Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies. Stroke. 2024;55:50. doi:10.1161/STROKEAHA.123.044281
- Olshansky B, Bhatt DL, Miller M, Steg PG, Brinton EA, et al. Cardiovascular Benefits of Icosapent Ethyl in Patients With and Without Atrial Fibrillation in REDUCE-IT. J Am Heart Assoc. 2023;12:e026756. doi:10.1161/JAHA.121.026756
- Bork CS, Lundbye-Christensen S, Venø SK, Lasota AN, Tjønneland A, et al. Intake of marine and plant-derived n-3 fatty acids and development of atherosclerotic cardiovascular disease in the Danish Diet, Cancer and Health cohort. Eur J Nutr. 2023;62:1389. doi:10.1007/s00394-022-03081-w
- Suzuki K, Sato H, Mori H, Matsumoto R, Arimoto Y, et al. Early Enteral Nutrition with High-Protein Whey Peptide Digestive Nutrients May Improve Prognosis in Subarachnoid Hemorrhage Patients. Medicina (Kaunas). 2022;58. doi:10.3390/medicina58091264
- Andone S, Farczádi L, Imre S, Bălașa R. Fatty Acids and Lipid Paradox-Neuroprotective Biomarkers in Ischemic Stroke. Int J Mol Sci. 2022;23. doi:10.3390/ijms231810810
- Yokoyama Y, Kuno T, Morita SX, Slipczuk L, Takagi H, et al. Eicosapentaenoic Acid for Cardiovascular Events Reduction- Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. J Cardiol. 2022;80:416. doi:10.1016/j.jjcc.2022.07.008
- Zhang W, Liu Y, Wu Y, Wang Z, Liu X, et al. ROS-triggered biomimetic hydrogel soft scaffold for ischemic stroke repair. Biomaterials. 2025;319:123217. doi:10.1016/j.biomaterials.2025.123217
- Liu C, Guo J, Guan L, Li C, Hu X, et al. Docosahexaenoic acid protects against ischemic stroke in diabetic mice by inhibiting inflammatory responses and apoptosis. Exp Neurol. 2025;385:115075. doi:10.1016/j.expneurol.2024.115075
- Shi F, Chowdhury R, Sofianopoulou E, Koulman A, Sun L, et al. Association of circulating fatty acids with cardiovascular disease risk: analysis of individual-level data in three large prospective cohorts and updated meta-analysis. Eur J Prev Cardiol. 2025;32:233. doi:10.1093/eurjpc/zwae315
- Wang Y, Yang B, Wang C. The association between fatty acids and atherosclerotic diseases: A mendelian randomization study. Clin Nutr ESPEN. 2024;63:447. doi:10.1016/j.clnesp.2024.06.018
- Ament Z, Patki A, Bhave VM, Kijpaisalratana N, Jones AC, et al. Omega-3 Fatty Acids and Risk of Ischemic Stroke in REGARDS. Transl Stroke Res. 2024. doi:10.1007/s12975-024-01256-7
- Kong J, Zou R, Chu R, Hu N, Liu J, et al. An Ultrasmall Cu/CuO Nanoparticle-Based Diselenide-Bridged Nanoplatform Mediating Reactive Oxygen Species Scavenging and Neuronal Membrane Enhancement for Targeted Therapy of Ischemic Stroke. ACS Nano. 2024;18:4140. doi:10.1021/acsnano.3c08734
- Lv H, Jia S, Sun Y, Pang M, Lv E, et al. Docosahexaenoic acid promotes M2 microglia phenotype via activating PPARγ-mediated ERK/AKT pathway against cerebral ischemia-reperfusion injury. Brain Res Bull. 2023;199:110660. doi:10.1016/j.brainresbull.2023.110660
- Yamagata K. Docosahexaenoic acid inhibits ischemic stroke to reduce vascular dementia and Alzheimer's disease. Prostaglandins Other Lipid Mediat. 2023;167:106733. doi:10.1016/j.prostaglandins.2023.106733
- Li Y, Zhang M, Li S, Zhang L, Kim J, et al. Selective ischemic-hemisphere targeting Ginkgolide B liposomes with improved solubility and therapeutic efficacy for cerebral ischemia-reperfusion injury. Asian J Pharm Sci. 2023;18:100783. doi:10.1016/j.ajps.2023.100783
- Sun E, Zhang J, Deng Y, Wang J, Wu Q, et al. Docosahexaenoic Acid Alleviates Brain Damage by Promoting Mitophagy in Mice with Ischaemic Stroke. Oxid Med Cell Longev. 2022;2022:3119649. doi:10.1155/2022/3119649
