Zinc
9
Zinc alleviates diabetic muscle atrophy
Zinc Alleviates Diabetic Muscle Atrophy via Modulation of the SIRT1/FoxO1 Autophagy Pathway Through GPR39.
Most Relevant Research
Our investigation aimed to understand how zinc affects muscle atrophy in diabetes, a serious complication that leads to muscle loss. Using diabetes-induced mice, we treated them with zinc sulfate for six weeks and observed notable improvements in their muscle condition.
We conducted various analyses to evaluate the impact of zinc on autophagy—the process that helps manage muscle mass. The results were promising; zinc appeared to enhance muscle recovery by regulating specific molecular pathways connected to muscle health.
Additionally, our in vitro studies with diabetic muscle cells revealed similar results, with zinc supplementation proving beneficial in reducing excessive autophagy. Overall, this suggests that incorporating zinc into treatment plans could be a promising approach to counteract muscle deterioration in diabetic patients.
We conducted various analyses to evaluate the impact of zinc on autophagy—the process that helps manage muscle mass. The results were promising; zinc appeared to enhance muscle recovery by regulating specific molecular pathways connected to muscle health.
Additionally, our in vitro studies with diabetic muscle cells revealed similar results, with zinc supplementation proving beneficial in reducing excessive autophagy. Overall, this suggests that incorporating zinc into treatment plans could be a promising approach to counteract muscle deterioration in diabetic patients.
8.8
Immune system support
Most Useful Review
Zinc is essential for DNA synthesis, wound healing, and hormonal balance. It's crucial for proper immune function and can help prevent colds and other infections. Zinc deficiency can lead to frequent illnesses and has been linked to diabetes. Older adults often suffer from insufficient zinc, which can impact healing and immunity. It’s vital for overall health and well-being.
Vitamins
8
Jamun juice vitamin D benefits
Characterization of jamun () juice fortified with nanoemulsified vitamin D: and assessment of its nutraceutical value and anti-diabetic potential.
Most Relevant Research
We sought to explore the effects of vitamin D on diabetes by fortifying jamun juice with this essential nutrient. Our approach involved creating a nanoemulsion of vitamin D using a low-temperature sonication method, which allowed us to enhance its presence in the juice.
The resulting drink, known as vitamin D fortified jamun juice (VDFJJ), showcased impressive nutritional attributes. It contained notable levels of total polyphenols and flavonoids, along with a high antioxidant activity of 94.2%.
When we examined its anti-diabetic potential, VDFJJ demonstrated significant inhibition of key enzymes related to carbohydrate digestion. Specifically, it showed effective inhibition of α-amylase and α-glucosidase, which play crucial roles in sugar absorption in the body.
Additionally, in our animal models that were deficient in vitamin D, we noted considerable improvements in various serum levels after four weeks of consuming the fortified juice. Results indicated increased levels of 25-OHD and calcium, among others, showcasing vitamin D's positive impact.
Overall, our nanoemulsion method appeared to boost vitamin D's solubility and bioavailability in a delicious beverage, paving the way for innovative solutions to tackle vitamin D deficiency while possibly aiding in diabetes management.
The resulting drink, known as vitamin D fortified jamun juice (VDFJJ), showcased impressive nutritional attributes. It contained notable levels of total polyphenols and flavonoids, along with a high antioxidant activity of 94.2%.
When we examined its anti-diabetic potential, VDFJJ demonstrated significant inhibition of key enzymes related to carbohydrate digestion. Specifically, it showed effective inhibition of α-amylase and α-glucosidase, which play crucial roles in sugar absorption in the body.
Additionally, in our animal models that were deficient in vitamin D, we noted considerable improvements in various serum levels after four weeks of consuming the fortified juice. Results indicated increased levels of 25-OHD and calcium, among others, showcasing vitamin D's positive impact.
Overall, our nanoemulsion method appeared to boost vitamin D's solubility and bioavailability in a delicious beverage, paving the way for innovative solutions to tackle vitamin D deficiency while possibly aiding in diabetes management.
9.5
Vitamin D recommendation
Most Useful Review
It appears that vitamin D deficiency occurs even in sunny countries like Italy and Mexico. The optimal level of vitamin D is between 60-100 ng/ml, ideally measured by mass spectrometry. Many labs use ELISA, which underestimates levels. Vitamin D, being a steroid hormone, when deficient can lead to conditions including diabetes. After taking 10,000 IU of vitamin D daily, my levels rose from 18 to 111 ng/ml. I believe everyone should consider having it in their home remedies.
Choline
8.8
Improved mood, diabetes relief
Most Useful Review
In combination with other supplements, I felt an improvement in my mood and energy. I managed to lose weight while addressing my liver fat, which is crucial for managing diabetes and insulin resistance. Siosis helped me discontinue antidepressants and is beneficial for diabetes.
9.5
Improved glucose levels
Most Useful Review
Since taking Now's inositol, my glycated haemoglobin levels have significantly improved over time. Each check-up reveals lower glycated levels, which is wonderful news for my diabetes management. The brand's quality is outstanding.
Olive Leaf
10
Effective for diabetes
Most Useful Review
Olive leaf extract is scientifically proven to be an excellent antiviral and antioxidant. It prevents heart and vascular diseases, diabetes, and more. After COVID-19, I began using it to restore blood vessel elasticity, and the capsules I found are easier to take than liquids. I fully recommend it!
8.3
Proven diabetes aid
Most Useful Review
The effectiveness of olive leaves and oleuropein in lowering blood pressure and providing health benefits is proven. Their anti-inflammatory and antioxidant properties help fight diabetes and other serious diseases.
Tumeric
9.5
Blood sugar decrease
Most Useful Review
Great curcumin. A sister I know took curcumin alongside her diabetes medication and saw her blood sugar levels finally drop to a safe level. The doctor may lower her medication at her next appointment if she continues with curcumin. Thank goodness!
9.5
Better health overall
Most Useful Review
I bought curcumin for my father with type 2 diabetes and hypertension. After two weeks of use, he reported feeling much better.
Enzymes
7
Nattokinase shows promise in diabetes
Effect of nattokinase on the pathological conditions in streptozotocin induced diabetic rats.
Most Relevant Research
We explored how nattokinase (NK), a naturally occurring enzyme with anti-inflammatory and fibrinolytic effects, influences diabetes in a study using diabetic rats. Specifically, we focused on its potential to mitigate the harmful effects of diabetes, particularly in relation to blood glucose levels, plasma proteins, and inflammation.
In our experiment, we divided STZ-induced diabetic rats into three groups: a control group on a basic diet, a low-NK diet group, and a high-NK diet group. Over 14 days, we noticed that the high-NK diet significantly reduced glycogen buildup in the renal tubules and lowered certain inflammatory markers, specifically C-reactive protein (CRP) levels, by day 14. Surprisingly, while significant improvements were noted in the inflammatory response, the high NK diet did not lead to reductions in blood glucose levels.
It seems that the beneficial effects of NK in terms of preventing additional complications in diabetes are distinct from its impact on blood sugar control. The results suggest that NK may play a crucial role in decreasing inflammation and tissue damage without directly affecting glucose levels. Yet, it's unclear whether these positive outcomes stem from the NK itself or from the breakdown products created during digestion.
In our experiment, we divided STZ-induced diabetic rats into three groups: a control group on a basic diet, a low-NK diet group, and a high-NK diet group. Over 14 days, we noticed that the high-NK diet significantly reduced glycogen buildup in the renal tubules and lowered certain inflammatory markers, specifically C-reactive protein (CRP) levels, by day 14. Surprisingly, while significant improvements were noted in the inflammatory response, the high NK diet did not lead to reductions in blood glucose levels.
It seems that the beneficial effects of NK in terms of preventing additional complications in diabetes are distinct from its impact on blood sugar control. The results suggest that NK may play a crucial role in decreasing inflammation and tissue damage without directly affecting glucose levels. Yet, it's unclear whether these positive outcomes stem from the NK itself or from the breakdown products created during digestion.
9.5
Health improvement
Most Useful Review
After extensive research, I bought this for my 55-year-old father who has diabetes, blood pressure issues, and kidney stones. He reports that it's wonderful and his health has improved. I'm thankful for this product and IHerb’s excellent quality.
9.5
Weight loss benefits
Most Useful Review
I definitely recommend it for weight loss and gastrointestinal problems. This natural adsorbent effectively cleanses the gastrointestinal tract. I bought the husk mainly for preventive reasons. Psyllium seed husks help with weight loss, cleanse the intestines, remove toxins, lower cholesterol and blood sugar levels, and boost immunity. I've noticed results quickly: my intestines began functioning well, cravings were suppressed, my skin condition improved, and I finally started to lose weight! I recommend everyone to include psyllium in their diet!
8.8
Positive mood enhancement
Most Useful Review
Excellent value for Omega-3! I take it for diabetes and find it boosts my mood. It's crucial for our bodies since we can't produce it ourselves. Omega-3 has numerous benefits, including reducing harmful fats in blood, aiding mental health, and supporting heart function. I recommend this supplement for anyone, especially for sports and overall well-being.
Elderberry
9.5
Diabetes-friendly syrup
Most Useful Review
I bought sugar-free elderberry for my diabetic mother. It effectively helps at the first signs of illness without sugar, making it a good choice for diabetics, as sugar-free syrups are not always available.
8.8
Supports immune system
Most Useful Review
Suitable for vegans, I take six capsules daily for my immunity. Elderberry strengthens the immune system, lowers cholesterol, and aids diabetes management by reducing the severity of colds and flu symptoms.
Vitamin Bs
7
Alpha-Lipoic Acid reduces AGEs
Alpha-Lipoic Acid Treatment Reduces the Levels of Advanced End Glycation Products in Type 2 Diabetes Patients with Neuropathy.
Most Relevant Research
We explored the potential benefits of alpha-lipoic acid (ALA) for those with type 2 diabetes (T2DM) and nerve complications, known as neuropathy. In our study, we focused on how ALA affects advanced end glycation products (AGEs), which are harmful compounds that can worsen the condition by damaging blood vessels and nerve tissues.
Our six-month intervention involved 54 T2DM patients with neuropathy who continued their prescribed medications while taking 600 mg of ALA daily. We contrasted their results with a control group of 24 matched patients without neuropathy.
We observed that ALA treatment significantly reduced the levels of AGEs, demonstrating its efficacy in lowering these harmful substances in individuals with diabetes (from 11.89 to 10.95 AU/μg). However, we noted that ALA did not influence other markers like soluble AGE receptor (sRAGE) levels or the AGEs/sRAGE ratio.
Additionally, we found correlations indicating that as AGEs decreased, improvements were noted in nerve function and other health markers. Overall, results suggest that ALA could be a beneficial treatment option for improving diabetic neuropathy and enhancing endothelial function, although it doesn't isolate its benefits from other existing diabetes medications.
Our six-month intervention involved 54 T2DM patients with neuropathy who continued their prescribed medications while taking 600 mg of ALA daily. We contrasted their results with a control group of 24 matched patients without neuropathy.
We observed that ALA treatment significantly reduced the levels of AGEs, demonstrating its efficacy in lowering these harmful substances in individuals with diabetes (from 11.89 to 10.95 AU/μg). However, we noted that ALA did not influence other markers like soluble AGE receptor (sRAGE) levels or the AGEs/sRAGE ratio.
Additionally, we found correlations indicating that as AGEs decreased, improvements were noted in nerve function and other health markers. Overall, results suggest that ALA could be a beneficial treatment option for improving diabetic neuropathy and enhancing endothelial function, although it doesn't isolate its benefits from other existing diabetes medications.
9.5
Reduces neuropathy pain
Most Useful Review
My husband has type 2 diabetes and experiences painful neuropathy. After two months of taking ALA, the pain lessened and his A1C dropped. With biotin added, it’s convenient, and we both feel good about the results.
Chromium
7.5
Reduced cholesterol
Most Useful Review
I bought this for my mother, who has high cholesterol. Cinnamon helps reduce 'bad' cholesterol and regulates blood sugar, aiding her diabetes management. Although she finds the tablets large, she mixes them into liquids or porridge.
10
Weight loss success
Most Useful Review
Eat what you enjoy, but take the pills (usually two) with food. In my experience, it took three months for significant results, leading to effortless weight loss without altering my diet. Be cautious if you have diabetes, as it may lower blood sugar levels. My husband lost 60 pounds in a month, while I lost 80 pounds in three months without dietary changes.
Taurine
8
Taurine's role in diabetes therapy
Enhancing metformin efficacy with cholecalciferol and taurine in diabetes therapy: Potential and limitations.
Most Relevant Research
The recent research focused on the effects of taurine, in combination with metformin and cholecalciferol (vitamin D3), on managing type 2 diabetes mellitus (T2DM) in a rat model. This interesting approach aimed to address more than just blood sugar levels, hoping to tackle related complications such as oxidative stress and inflammation.
We observed that the combination treatment showed promise in improving glycemic control and minimizing lipid issues. However, it's essential to recognize that the study does not provide a clear picture of taurine's isolated impact on diabetes, as its effects were only examined in conjunction with other substances.
Furthermore, the study was limited by a lack of safety data and detailed information about how taurine works at a molecular level. While the findings suggest potential benefits, we need to be cautious and seek further research to fully understand taurine's role and ensure its safe use in diabetes therapy.
We observed that the combination treatment showed promise in improving glycemic control and minimizing lipid issues. However, it's essential to recognize that the study does not provide a clear picture of taurine's isolated impact on diabetes, as its effects were only examined in conjunction with other substances.
Furthermore, the study was limited by a lack of safety data and detailed information about how taurine works at a molecular level. While the findings suggest potential benefits, we need to be cautious and seek further research to fully understand taurine's role and ensure its safe use in diabetes therapy.
9.5
Stabilises blood sugar
Most Useful Review
I appreciate taurine for stabilising sugars in diabetes. It prevents surges and has improved my health for six months. It does not raise blood pressure, so I take it without worry.
Polygonum Cuspidatum Complex
9.5
Reduces oxidative stress
Most Useful Review
Resveratrol is effective for diabetes as it reduces excessive sorbitol accumulation, thereby alleviating oxidative stress that harms cells and hinders insulin resistance.
9.5
A good drug
Most Useful Review
Resveratrol enhances insulin sensitivity and combats oxidative stress. I found it effective in alleviating the condition of diabetes patients while preventing complications. It’s truly a valuable drug.
Alpha Lipoic Acid
7
Alpha-Lipoic Acid reduces AGEs
Alpha-Lipoic Acid Treatment Reduces the Levels of Advanced End Glycation Products in Type 2 Diabetes Patients with Neuropathy.
Most Relevant Research
We explored the potential benefits of alpha-lipoic acid (ALA) for those with type 2 diabetes (T2DM) and nerve complications, known as neuropathy. In our study, we focused on how ALA affects advanced end glycation products (AGEs), which are harmful compounds that can worsen the condition by damaging blood vessels and nerve tissues.
Our six-month intervention involved 54 T2DM patients with neuropathy who continued their prescribed medications while taking 600 mg of ALA daily. We contrasted their results with a control group of 24 matched patients without neuropathy.
We observed that ALA treatment significantly reduced the levels of AGEs, demonstrating its efficacy in lowering these harmful substances in individuals with diabetes (from 11.89 to 10.95 AU/μg). However, we noted that ALA did not influence other markers like soluble AGE receptor (sRAGE) levels or the AGEs/sRAGE ratio.
Additionally, we found correlations indicating that as AGEs decreased, improvements were noted in nerve function and other health markers. Overall, results suggest that ALA could be a beneficial treatment option for improving diabetic neuropathy and enhancing endothelial function, although it doesn't isolate its benefits from other existing diabetes medications.
Our six-month intervention involved 54 T2DM patients with neuropathy who continued their prescribed medications while taking 600 mg of ALA daily. We contrasted their results with a control group of 24 matched patients without neuropathy.
We observed that ALA treatment significantly reduced the levels of AGEs, demonstrating its efficacy in lowering these harmful substances in individuals with diabetes (from 11.89 to 10.95 AU/μg). However, we noted that ALA did not influence other markers like soluble AGE receptor (sRAGE) levels or the AGEs/sRAGE ratio.
Additionally, we found correlations indicating that as AGEs decreased, improvements were noted in nerve function and other health markers. Overall, results suggest that ALA could be a beneficial treatment option for improving diabetic neuropathy and enhancing endothelial function, although it doesn't isolate its benefits from other existing diabetes medications.
9.5
Improved memory function
Most Useful Review
As I aged, I noticed my memory declining. Checking my thiamine levels showed they were low, especially on strict diets. Since taking Benfotiamine, I’ve experienced improvements in memory, sleep, and reduced irritability, making it easier to manage my diabetes. I suggest taking this complex as it also protects skin health.
Quercetin
8
Quercetin inhibits glucose-regulating enzymes
Inhibitory effects of phenolic compounds from blueberry leaf on α-amylase and α-glucosidase: kinetics, mode of action, and molecular interactions.
Most Relevant Research
We analyzed how quercetin, a key component of blueberry leaf polyphenols, influences diabetes by examining its effects on enzymes that regulate glucose levels. Our study utilized various techniques to understand the interactions between these compounds and the digestive enzymes α-amylase and α-glucosidase, both of which play significant roles in carbohydrate digestion.
During our research, we found that quercetin exhibited the most potent inhibitory effects on these enzymes. Specifically, it showed stronger action against α-glucosidase than α-amylase, which means it could potentially be more beneficial in managing blood sugar levels. Furthermore, we discovered that blueberry leaf polyphenols acted as mixed-type inhibitors, indicating that they hinder enzyme activity in multiple ways.
By evaluating the binding characteristics and the stability of the complexes formed between quercetin and the enzymes, we uncovered that α-glucosidase has a greater affinity for blueberry leaf compounds than α-amylase does. These molecular interactions suggest that quercetin might be a valuable addition to diabetes management strategies, particularly through its effects on glucose metabolism.
Overall, this research sheds light on how quercetin, derived from blueberry leaves, may help in controlling diabetes by effectively inhibiting key digestive enzymes.
During our research, we found that quercetin exhibited the most potent inhibitory effects on these enzymes. Specifically, it showed stronger action against α-glucosidase than α-amylase, which means it could potentially be more beneficial in managing blood sugar levels. Furthermore, we discovered that blueberry leaf polyphenols acted as mixed-type inhibitors, indicating that they hinder enzyme activity in multiple ways.
By evaluating the binding characteristics and the stability of the complexes formed between quercetin and the enzymes, we uncovered that α-glucosidase has a greater affinity for blueberry leaf compounds than α-amylase does. These molecular interactions suggest that quercetin might be a valuable addition to diabetes management strategies, particularly through its effects on glucose metabolism.
Overall, this research sheds light on how quercetin, derived from blueberry leaves, may help in controlling diabetes by effectively inhibiting key digestive enzymes.
7.5
Pain reduction
Most Useful Review
I appreciate that Quercetin and bromelain can be taken together. Quercetin possesses anti-inflammatory, antioxidant, and blood pressure regulating qualities, which I find beneficial. The combination helps with pain and inflammation, especially for diabetic conditions.
Selenium
9
Selenium's role in diabetes treatment
Nanometerizing Taxifolin Into Selenized Liposomes to Ameliorate Its Hypoglycemic Effect by Optimizing Drug Release and Bioavailability.
Most Relevant Research
We sought to understand how selenium, when combined with taxifolin, might improve treatment options for diabetes mellitus. The focus was on creating selenized liposomes, or Tax-Se@LPs, that would enhance the delivery and effectiveness of taxifolin, a natural compound known for its potential health benefits.
Through a specialized manufacturing technique, we developed these nanometric liposomes and assessed their performance in preclinical settings. Our findings indicated that Tax-Se@LPs not only improved the absorption of taxifolin in the digestive system but also significantly reduced blood glucose levels in diabetic models. With a relative bioavailability of 216.65%, the selenized formulation demonstrated a more prolonged effect compared to other delivery methods.
Despite these promising results, our study did not isolate the effectiveness of selenium on its own. The benefits observed were largely attributed to the advanced delivery system rather than the selenium content alone. Therefore, while increased bioavailability and hypoglycemic effects are evident from using Tax-Se@LPs, the specific role that selenium plays in these outcomes needs further exploration for a clearer understanding.
Through a specialized manufacturing technique, we developed these nanometric liposomes and assessed their performance in preclinical settings. Our findings indicated that Tax-Se@LPs not only improved the absorption of taxifolin in the digestive system but also significantly reduced blood glucose levels in diabetic models. With a relative bioavailability of 216.65%, the selenized formulation demonstrated a more prolonged effect compared to other delivery methods.
Despite these promising results, our study did not isolate the effectiveness of selenium on its own. The benefits observed were largely attributed to the advanced delivery system rather than the selenium content alone. Therefore, while increased bioavailability and hypoglycemic effects are evident from using Tax-Se@LPs, the specific role that selenium plays in these outcomes needs further exploration for a clearer understanding.
9.5
Boosts immune system
Most Useful Review
Selenium is vital for cancer protection and immunity against viruses. It aids pancreatic cell growth and improves glucose absorption, essential for managing diabetes by reducing insulin resistance. This mineral is best absorbed with fat-soluble vitamins A, D, and E, and it’s crucial for synthesising thyroid hormones.
Calcium
7
Magnesium water enhances metabolic health
Effects of deep ocean-derived magnesium-enhanced water on metabolic diseases with microbiome changes.
Most Relevant Research
We explored the effects of magnesium (Mg) derived from deep ocean sources on adults dealing with hypertension, diabetes, or high cholesterol in a carefully designed clinical trial. Participants consumed either magnesium-enriched water (MEW) with 80 mg of Mg or a placebo containing only 6 mg of Mg daily for four weeks.
Throughout the study, we observed that MEW led to notable improvements in several health markers, such as body mass index (BMI), insulin levels, triglycerides, and fatigue. Interestingly, regardless of magnesium levels in the water, consuming more fluids helped reduce harmful substances in the body, like a byproduct of polycyclic aromatic hydrocarbons (PAHs) and an oxidative stress indicator called malondialdehyde.
Moreover, we noted significant changes in the gut microbiome of those drinking MEW, indicating a more diverse and balanced microbial environment. The presence of beneficial bacteria associated with magnesium intake suggested potential long-term health benefits, implying that MEW could play a role in preventing cardiovascular disease and type 2 diabetes.
Overall, it seems that magnesium-enriched water not only supports metabolic health but may also enhance gut flora, which is crucial for maintaining overall wellness.
Throughout the study, we observed that MEW led to notable improvements in several health markers, such as body mass index (BMI), insulin levels, triglycerides, and fatigue. Interestingly, regardless of magnesium levels in the water, consuming more fluids helped reduce harmful substances in the body, like a byproduct of polycyclic aromatic hydrocarbons (PAHs) and an oxidative stress indicator called malondialdehyde.
Moreover, we noted significant changes in the gut microbiome of those drinking MEW, indicating a more diverse and balanced microbial environment. The presence of beneficial bacteria associated with magnesium intake suggested potential long-term health benefits, implying that MEW could play a role in preventing cardiovascular disease and type 2 diabetes.
Overall, it seems that magnesium-enriched water not only supports metabolic health but may also enhance gut flora, which is crucial for maintaining overall wellness.
9.5
Reduced muscle pain
Most Useful Review
Great product! I began taking it due to muscle pain from very low vitamin D. After a week, my muscle discomfort has nearly vanished. I feel energetic in the mornings. I also take selenium, vitamin E, D, zinc, and vitamins B and C. Magnesium is essential for diabetics; my 16-year-old daughter with type 1 diabetes takes one tablet before bed.
Magnesium
7
Magnesium water enhances metabolic health
Effects of deep ocean-derived magnesium-enhanced water on metabolic diseases with microbiome changes.
Most Relevant Research
We explored the effects of magnesium (Mg) derived from deep ocean sources on adults dealing with hypertension, diabetes, or high cholesterol in a carefully designed clinical trial. Participants consumed either magnesium-enriched water (MEW) with 80 mg of Mg or a placebo containing only 6 mg of Mg daily for four weeks.
Throughout the study, we observed that MEW led to notable improvements in several health markers, such as body mass index (BMI), insulin levels, triglycerides, and fatigue. Interestingly, regardless of magnesium levels in the water, consuming more fluids helped reduce harmful substances in the body, like a byproduct of polycyclic aromatic hydrocarbons (PAHs) and an oxidative stress indicator called malondialdehyde.
Moreover, we noted significant changes in the gut microbiome of those drinking MEW, indicating a more diverse and balanced microbial environment. The presence of beneficial bacteria associated with magnesium intake suggested potential long-term health benefits, implying that MEW could play a role in preventing cardiovascular disease and type 2 diabetes.
Overall, it seems that magnesium-enriched water not only supports metabolic health but may also enhance gut flora, which is crucial for maintaining overall wellness.
Throughout the study, we observed that MEW led to notable improvements in several health markers, such as body mass index (BMI), insulin levels, triglycerides, and fatigue. Interestingly, regardless of magnesium levels in the water, consuming more fluids helped reduce harmful substances in the body, like a byproduct of polycyclic aromatic hydrocarbons (PAHs) and an oxidative stress indicator called malondialdehyde.
Moreover, we noted significant changes in the gut microbiome of those drinking MEW, indicating a more diverse and balanced microbial environment. The presence of beneficial bacteria associated with magnesium intake suggested potential long-term health benefits, implying that MEW could play a role in preventing cardiovascular disease and type 2 diabetes.
Overall, it seems that magnesium-enriched water not only supports metabolic health but may also enhance gut flora, which is crucial for maintaining overall wellness.
9.5
Improves diabetes symptoms
Most Useful Review
I purchased this chelate for my mother, as other forms didn't work for her digestive issues. It has calmed her and improved her sleep, and her diabetes-related cramps have vanished.
L Carnosine
8
Effects of L-carnosine on diabetes
Combined loss of glyoxalase 1 and aldehyde dehydrogenase 3a1 amplifies dicarbonyl stress, impairs proteasome activity resulting in hyperglycemia and activated retinal angiogenesis.
Most Relevant Research
In our exploration of how L-carnosine treatment affects diabetes, we focused on the interplay between detoxification enzymes, particularly glyoxalase 1 (GLO1) and aldehyde dehydrogenase 3A1 (ALDH3A1). We generated a unique combination of zebrafish that lacked both GLO1 and ALDH3A1 to better understand how their absence influences metabolic processes, especially dicarbonyl stress.
Through our observations, we found that the absence of these enzymes led to an increase in methylglyoxal (MG) and its harmful derivative MG-H1. This accumulation had dire consequences, resulting in impaired proteasome function, which in turn disrupted glucose control and spurred abnormal blood vessel growth in the eye. Encouragingly, we also noted that treatment with L-carnosine could reverse some of these detrimental effects, underscoring its potential role as a therapeutic intervention.
While we recognize that L-carnosine was part of a broader treatment landscape, its protective impact against the harmful accumulation triggered by enzyme loss highlights its significance. Future research could build on these findings to understand L-carnosine's specific contributions and clarify its effectiveness in diabetes management.
Through our observations, we found that the absence of these enzymes led to an increase in methylglyoxal (MG) and its harmful derivative MG-H1. This accumulation had dire consequences, resulting in impaired proteasome function, which in turn disrupted glucose control and spurred abnormal blood vessel growth in the eye. Encouragingly, we also noted that treatment with L-carnosine could reverse some of these detrimental effects, underscoring its potential role as a therapeutic intervention.
While we recognize that L-carnosine was part of a broader treatment landscape, its protective impact against the harmful accumulation triggered by enzyme loss highlights its significance. Future research could build on these findings to understand L-carnosine's specific contributions and clarify its effectiveness in diabetes management.
9.5
Effective for diabetes
Most Useful Review
Health must-have. One of the most effective supplements available. My mother deals with toxic stress and diabetes, and L-Carnosine is literally the answer to her overall health issues, also helping with age-related fatigue. Thanks, Now and iHerb.