Multivitamins
9.5
Gentle on ulcers
Most Useful Review
I switched to this form of vitamin C as it is non-acidic and doesn't irritate my stomach lining. It’s ideal for those with ulcers or gastritis. The citrus bioflavonoids enhance absorption. I highly recommend it!
9.5
Safe for ulcers
Most Useful Review
Vitamin C with bioflavonoids works well. Ester-C is gentle on sensitive stomachs and suitable for those with ulcers. Despite containing 500 mg, which is above the daily norm, it can be taken safely during illness. I find it effective alongside vitamin D3 and zinc.
Vitamins
9
Vitamin D3 mitigates gastric injury
Vitamin D3 mitigates aspirin-induced gastric injury by modulating gastrokines, E-cadherin, and inhibiting NLRP3 and NF-κB/MMP-9 signaling pathway.
Most Relevant Research
We explored the effects of Vitamin D3 on stomach ulcers caused by aspirin, focusing specifically on how it influences certain molecules in the stomach lining. In our study, we divided 24 rats into four groups: a control group, a group receiving Vitamin D3 without any gastric injury, a group with aspirin-induced gastric injuries, and a group treated with Vitamin D3 after such injuries occurred.
Our findings were quite promising. Vitamin D3 seemed to play a protective role against the damage caused by aspirin. It significantly increased levels of important protective molecules like E-Cadherin, GKN1 (a type of gastrokine), and mucin 5AC. These molecules are essential for maintaining the integrity of the stomach lining, helping to mitigate the effects of oxidative stress and inflammation often seen in gastric injuries.
Furthermore, Vitamin D3 treatment helped improve both the structure and function of gastric tissue. By reducing inflammation pathways, particularly those involving NLRP3 and NF-κB, Vitamin D3 demonstrated its potential as a protective agent in the context of aspirin-induced gastric injury.
Our findings were quite promising. Vitamin D3 seemed to play a protective role against the damage caused by aspirin. It significantly increased levels of important protective molecules like E-Cadherin, GKN1 (a type of gastrokine), and mucin 5AC. These molecules are essential for maintaining the integrity of the stomach lining, helping to mitigate the effects of oxidative stress and inflammation often seen in gastric injuries.
Furthermore, Vitamin D3 treatment helped improve both the structure and function of gastric tissue. By reducing inflammation pathways, particularly those involving NLRP3 and NF-κB, Vitamin D3 demonstrated its potential as a protective agent in the context of aspirin-induced gastric injury.
9.5
Improvement observed
Most Useful Review
The required dosage of vitamin A varies significantly between individuals, particularly for those with dry eyes, asthma, gastrointestinal issues, or a history of cancer. Due to my low protein intake, I've gradually increased my dosage to 100,000 units over a year. Remarkably, my persistent gastritis, unresolved for over ten years, has cleared, eliminating the need for medication.
Slippery Elm
9.5
Ulcer healing success
Most Useful Review
After discovering erosions and an ulcer in my husband's duodenum, the doctor recommended slippery elm. Within two weeks of combining it with other supplements, a follow-up gastroscopy showed no signs of erosion, demonstrating its healing properties effectively. I highly recommend slippery elm for digestive health.
8.3
Immediate ulcer pain relief
Most Useful Review
I have suffered from a duodenal ulcer for a month. Pharmaceutical remedies were ineffective; however, taking slippery elm separately worked remarkably well. Pain reduced almost immediately, and improvements were noticeable after a couple of doses.
Tumeric
9
Curcumin nanoparticles effective for ulcers
Synergistic effects of oleanolic acid and curcumin nanoparticles in gastric ulcer prevention.
Most Relevant Research
We explored the effectiveness of curcumin, a compound found in turmeric, in preventing gastric ulcers, especially given its known anti-inflammatory and antioxidant properties. To tackle the common issue of curcumin's poor absorption in the body, researchers developed special nanoparticles coated with oleanolic acid, which improved the stability and solubility of curcumin.
In our investigation, the oleanolic acid-coated curcumin nanoparticles, or OC NPs, were tested in both laboratory settings and live animal models. Not only did we observe a reduction in inflammation and oxidative stress in cells, but the nanoparticles also showed promising results in protecting mice from ethanol-induced gastric ulcers. This protection came with a decrease in inflammation and an increase in antioxidant levels in their systems.
Histological studies indicated that OC NPs better preserved the gastric mucosa while minimizing damage like fibrosis and cell death. Moreover, they stayed longer in the stomach, enhancing the targeted delivery of curcumin. Overall, our findings suggest that oleanolic acid-coated curcumin nanoparticles could be a safe and effective option to prevent gastric ulcers, making this approach a noteworthy advancement in gastrointestinal health.
In our investigation, the oleanolic acid-coated curcumin nanoparticles, or OC NPs, were tested in both laboratory settings and live animal models. Not only did we observe a reduction in inflammation and oxidative stress in cells, but the nanoparticles also showed promising results in protecting mice from ethanol-induced gastric ulcers. This protection came with a decrease in inflammation and an increase in antioxidant levels in their systems.
Histological studies indicated that OC NPs better preserved the gastric mucosa while minimizing damage like fibrosis and cell death. Moreover, they stayed longer in the stomach, enhancing the targeted delivery of curcumin. Overall, our findings suggest that oleanolic acid-coated curcumin nanoparticles could be a safe and effective option to prevent gastric ulcers, making this approach a noteworthy advancement in gastrointestinal health.
9.5
Effective for ulcers
Most Useful Review
The main active ingredient in turmeric is curcumin, which is known for its antioxidant and anti-inflammatory properties. Adding curcumin to anti-Helicobacter pylori therapy enhances its effectiveness. This opens new options for using turmeric to treat ulcers. Good results have also been reported for curcumin in conditions like ulcerative colitis and Crohn's disease. Moreover, it has therapeutic effects on inflammatory processes in the intestines and the pancreas, and it prevents fatty liver disease. Overall, turmeric holds promise for treating ulcers and various inflammatory conditions.
Vitamin B Complex
9.5
No more ulcers
Most Useful Review
Mouth ulcers have completely healed. Regardless of how many hours I sleep, I feel energised and no longer suffer from ulcers. After taking this supplement, I wake up earlier and feel fantastic. If you tire easily, I highly recommend trying it!
9.5
Unnoticed ulcers
Most Useful Review
I trust the quality of Now Foods. Since I started taking one tablet daily, I no longer experience mouth ulcers, even when tired or consuming carbs. This product is cost-effective compared to others I've tried, although the tablets are quite large and have a sour taste.
Probiotics
9
Saccharomyces boulardii aids ulcer treatment
Alleviates Colitis by Regulating FXR-NLRP3 Mediated Macrophage Pyroptosis.
Most Relevant Research
This study examined how Saccharomyces boulardii supernatant (SbS) impacts ulcerative colitis (UC) by activating the FXR-NLRP3 signaling pathway. We used a murine model to assess the effects of SbS compared to a control group.
Our findings showed that SbS not only activated FXR but also suppressed the NLRP3 inflammasome in colonic tissues. It reduced macrophage pyroptosis, a process linked to inflammation. However, the benefits were reversed by an FXR inhibitor, indicating that FXR’s activation is crucial for SbS's effects.
Our findings showed that SbS not only activated FXR but also suppressed the NLRP3 inflammasome in colonic tissues. It reduced macrophage pyroptosis, a process linked to inflammation. However, the benefits were reversed by an FXR inhibitor, indicating that FXR’s activation is crucial for SbS's effects.
9.5
Supports antibiotic treatment
Most Useful Review
Saccharomyces Boulardii has numerous advantages. It is the only probiotic I can take alongside antibiotics, which is crucial for preserving my gut flora, especially post-COVID. These fungi don’t colonise our intestines but significantly help to maintain a healthy microflora. It is also effective for ulcers caused by pathogenic strains.
Vitamin B12
9
Genetic insights into ulcer healing
Phenotype puzzle: the role of novel LMBRD1 gene variant in Cbl deficiency causing Dyskeratosis Congenita-like clinical manifestations.
Most Relevant Research
We delved into the complexities surrounding a specific genetic mutation in the LMBRD1 gene, which is linked to a variant form of cobalamin (vitamin B12) deficiency. This study highlighted a 15-year-old male with symptoms typical of Dyskeratosis Congenita, including skin hyperpigmentation and ulcers. After identifying a novel splice site deletion in the gene, we learned that this alteration can heavily impact vitamin B12 metabolism and lead to various clinical manifestations, including ulcers.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
9.5
Effective treatment
Most Useful Review
B12 has been beneficial for my mouth ulcers.
9.5
Improves ulcer treatment
Most Useful Review
Echinacea is my go-to for my child's respiratory issues and has great efficacy. My five-year-old loves the syrup, and since we started, her respiratory ailments improved remarkably, and I noted a significant reduction in ulcer issues.
9.5
Natural composition benefits
Most Useful Review
After discovering my estrogen dominance, I detoxified my home, hair, makeup, and food products. I ordered this eco-paste as fluorides and xenoprobiotics can enter the body through the gums. While fluoride is not the most dangerous ingredient, pastes with sulfates cause oral sensitivity and ulcers. This paste has a natural formula, pleasant taste, and is economical. I'm very pleased with it.
L Carnosine
9
Polaprezinc reduces ulcer inflammation
Aspergillusidone G Potentiates the Anti-Inflammatory Effects of Polaprezinc in LPS-Induced BV2 Microglia: A Bioinformatics and Experimental Study.
Most Relevant Research
We focused on the effects of polaprezinc (Pol), a compound that includes l-carnosine, and its ability to reduce inflammation in cells associated with neurodegenerative diseases. Through experiments involving LPS-induced BV-2 microglia, we observed that Pol successfully lowered the levels of nitric oxide (NO) and reactive oxygen species (ROS), which are often elevated during inflammatory responses.
Notably, Pol also suppressed the expression of key inflammatory markers, including iNOS, COX-2, IL-6, TNF-α, and IL-1β. These promising findings indicate that Pol could contribute beneficially to managing inflammation linked to ulcers.
Additionally, we investigated whether combining Pol with aspergillusidone G (Asp G) could further enhance its anti-inflammatory effects. What we found was quite remarkable: low doses of Asp G boosted Pol's ability to inhibit NO production from about 30% to an impressive 80%. Our analyses pointed toward the involvement of several molecular targets in this synergistic effect, further supporting Pol's potential role in addressing neuroinflammation.
Overall, while the study does suggest that l-carnosine, as part of Pol, plays a functional role concerning ulcers, it doesn’t isolate its specific contribution. Thus, more targeted research would be necessary to directly link l-carnosine's effectiveness to ulcer treatment.
Notably, Pol also suppressed the expression of key inflammatory markers, including iNOS, COX-2, IL-6, TNF-α, and IL-1β. These promising findings indicate that Pol could contribute beneficially to managing inflammation linked to ulcers.
Additionally, we investigated whether combining Pol with aspergillusidone G (Asp G) could further enhance its anti-inflammatory effects. What we found was quite remarkable: low doses of Asp G boosted Pol's ability to inhibit NO production from about 30% to an impressive 80%. Our analyses pointed toward the involvement of several molecular targets in this synergistic effect, further supporting Pol's potential role in addressing neuroinflammation.
Overall, while the study does suggest that l-carnosine, as part of Pol, plays a functional role concerning ulcers, it doesn’t isolate its specific contribution. Thus, more targeted research would be necessary to directly link l-carnosine's effectiveness to ulcer treatment.
9.5
Improved ulcers significantly
Most Useful Review
I've suffered from gastric ulcers for years, but since taking this with traditional Chinese medicine, my symptoms have notably improved.
Zinc
9
Zinc treatment has therapeutic potential
Treatment of Acute Ulcerative Colitis with Zinc Hyaluronate in Mice.
Most Relevant Research
We investigated the effects of zinc hyaluronate (ZnHA) on ulcerative colitis (UC) using a mouse model that simulates the condition. This study aimed to explore how ZnHA could potentially alleviate the symptoms of UC, focusing on factors like inflammation and gut health.
Our experiments showed that ZnHA significantly reduced key symptoms associated with UC, such as weight loss, loose stools, and the presence of blood in stools. We also noticed notable changes at a cellular level; ZnHA helped decrease levels of inflammatory markers like tumor necrosis factor-α and interleukin-6 while boosting interleukin-10, a factor known for anti-inflammatory effects.
Additionally, our findings revealed that ZnHA positively impacted gut bacteria. It fostered the growth of beneficial bacteria that produce propionic acid, which is crucial for gut health. We also observed that ZnHA enhanced the function of proteins that maintain the intestinal barrier, such as ZO-1 and occludin.
Overall, our exploration highlights the potential of ZnHA as a supportive treatment for UC by targeting inflammation and promoting a healthy gut environment. This study provides new insights that could encourage further development of hyaluronic acid-based treatments for UC and similar conditions.
Our experiments showed that ZnHA significantly reduced key symptoms associated with UC, such as weight loss, loose stools, and the presence of blood in stools. We also noticed notable changes at a cellular level; ZnHA helped decrease levels of inflammatory markers like tumor necrosis factor-α and interleukin-6 while boosting interleukin-10, a factor known for anti-inflammatory effects.
Additionally, our findings revealed that ZnHA positively impacted gut bacteria. It fostered the growth of beneficial bacteria that produce propionic acid, which is crucial for gut health. We also observed that ZnHA enhanced the function of proteins that maintain the intestinal barrier, such as ZO-1 and occludin.
Overall, our exploration highlights the potential of ZnHA as a supportive treatment for UC by targeting inflammation and promoting a healthy gut environment. This study provides new insights that could encourage further development of hyaluronic acid-based treatments for UC and similar conditions.
9.5
Reduction in complications
Most Useful Review
I find that zinc is critical for health. A deficiency can disrupt bodily functions, resulting in issues like skin diseases and ulcers. It's difficult to get adequate zinc from food alone, so I often rely on supplements. Additionally, recent studies indicate that zinc is more effective than vitamin C in combating colds by halting virus progression and softening disease severity. I'm pleased with its effectiveness in managing ulcers and would recommend it wholeheartedly.
Fish Oil
7
EPA and GLA show localized benefits
The Combined Administration of Eicosapentaenoic Acid (EPA) and Gamma-Linolenic Acid (GLA) in Experimentally Induced Colitis: An Experimental Study in Rats.
Most Relevant Research
We examined the effects of eicosapentaenoic acid (EPA) in conjunction with gamma-linolenic acid (GLA) on ulcerative colitis, a chronic inflammatory bowel disease. The study involved thirty-six male Wistar rats that were divided into three groups to observe how well these substances could impact the development of the disease.
Each group experienced a different treatment: one received only water, another was fed a high-caloric diet, and the last group consumed a diet rich in both EPA and GLA. We measured disease activity and inflammation levels, looking closely at the rats' intestinal, liver, spleen, and lung tissues to gauge the effects.
While we noted some positive changes—like lower inflammatory markers and reduced immune cell infiltration in the group receiving both EPA and GLA—overall, the differences in disease activity were not statistically significant. This suggests that while there might be localized anti-inflammatory benefits, the combined treatment did not markedly improve the overall ulcerative colitis symptoms compared to other diets.
In summary, our exploration into the combination of EPA and GLA shows promise toward improving some internal symptoms, but we did not find compelling evidence that this combination benefits the broader aspects of the disease.
Each group experienced a different treatment: one received only water, another was fed a high-caloric diet, and the last group consumed a diet rich in both EPA and GLA. We measured disease activity and inflammation levels, looking closely at the rats' intestinal, liver, spleen, and lung tissues to gauge the effects.
While we noted some positive changes—like lower inflammatory markers and reduced immune cell infiltration in the group receiving both EPA and GLA—overall, the differences in disease activity were not statistically significant. This suggests that while there might be localized anti-inflammatory benefits, the combined treatment did not markedly improve the overall ulcerative colitis symptoms compared to other diets.
In summary, our exploration into the combination of EPA and GLA shows promise toward improving some internal symptoms, but we did not find compelling evidence that this combination benefits the broader aspects of the disease.
9.5
Regulates ulcer conditions
Most Useful Review
Omega-3 helps in promoting overall health, particularly for children with developmental issues. It effectively regulates conditions like ulcers and prevents cardiovascular diseases. I noticed a marked difference in well-being, especially with managing ulcer-related problems while consuming Omega-3 regularly. I believe its anti-inflammatory effects are beneficial.
Coenzyme Q10
8
CoQ10 reduces piroxicam damage
Coenzyme Q10 supplementation mitigates piroxicam-induced oxidative injury and apoptotic pathways in the stomach, liver, and kidney.
Most Relevant Research
We explored how coenzyme Q10 (CoQ10) might protect against tissue damage caused by piroxicam, a common anti-inflammatory drug known to cause gastric and organ toxicity. In our investigation, we assigned rats to different groups, including controls and those receiving CoQ10, piroxicam, or a combination of both.
Over a 28-day period, we observed that administering piroxicam resulted in severe gastric ulcers as well as significant liver and kidney damage. These toxic effects appeared linked to oxidative stress and mitochondrial dysfunction. Elevated levels of malondialdehyde, along with decreased levels of protective antioxidants, indicated that harmful free radicals were at play. Additionally, we noticed an increase in apoptosis, or programmed cell death, in the affected organs, showcased by raised caspase-3 levels.
Interestingly, the inclusion of CoQ10 led to a noticeable reduction in oxidative damage and cell death caused by piroxicam. This suggests that CoQ10's ability to scavenge free radicals played a crucial role in mitigating the damage. Overall, our findings support CoQ10 as a potential protective agent against the harmful effects of piroxicam.
Over a 28-day period, we observed that administering piroxicam resulted in severe gastric ulcers as well as significant liver and kidney damage. These toxic effects appeared linked to oxidative stress and mitochondrial dysfunction. Elevated levels of malondialdehyde, along with decreased levels of protective antioxidants, indicated that harmful free radicals were at play. Additionally, we noticed an increase in apoptosis, or programmed cell death, in the affected organs, showcased by raised caspase-3 levels.
Interestingly, the inclusion of CoQ10 led to a noticeable reduction in oxidative damage and cell death caused by piroxicam. This suggests that CoQ10's ability to scavenge free radicals played a crucial role in mitigating the damage. Overall, our findings support CoQ10 as a potential protective agent against the harmful effects of piroxicam.
8.8
Reduced ulcer symptoms
Most Useful Review
I recommend Coenzyme Q10 for heart health. The body may lack this coenzyme after 20 years, leading to a decline. It acts as an antioxidant and aids energy metabolism. I took it regularly after 40, but needed to increase my dose for energy and reduced heart discomfort. It is advisable to avoid taking it during an ulcer flare-up. This product from Doctor's Best is affordable and easy to swallow. I felt energised after increasing the dosage.
Vitamin C
7
Vitamin C positively influences gut microbiome
Impact of Vitamins, Antibiotics, Probiotics, and History of COVID-19 on the Gut Microbiome in Ulcerative Colitis Patients: A Cross-Sectional Study.
Most Relevant Research
We explored how vitamin C affects the gut microbiome of patients with ulcerative colitis (UC) in a study involving 49 outpatient subjects. The participants were evaluated between June and December 2021, and they were divided into groups based on whether they had contracted COVID-19 in the prior six months. Our primary focus was to assess not just the impact of vitamin C, but also to consider the effects of antibiotics, probiotics, and the history of COVID-19 on their gut health.
Interestingly, we observed that those who used vitamin C supplements had more beneficial elements in their gut microbiome compared to those who did not. The study found a significant difference, indicating that vitamin C users had better microbiome readings, suggesting a positive influence on their gut health. However, while vitamin C presented statistically significant results, we noted that other factors such as antibiotic use also played a crucial role.
Importantly, the use of antibiotics negatively impacted the gut microbiome, which raises questions about the interplay between different treatments. There was also no significant impact found regarding mild COVID-19 on patients’ gut microbiomes, adding another layer to our understanding of these interactions. Ultimately, while vitamin C showed promise, the overall picture suggests that it's part of a broader landscape of factors affecting ulcerative colitis.
Interestingly, we observed that those who used vitamin C supplements had more beneficial elements in their gut microbiome compared to those who did not. The study found a significant difference, indicating that vitamin C users had better microbiome readings, suggesting a positive influence on their gut health. However, while vitamin C presented statistically significant results, we noted that other factors such as antibiotic use also played a crucial role.
Importantly, the use of antibiotics negatively impacted the gut microbiome, which raises questions about the interplay between different treatments. There was also no significant impact found regarding mild COVID-19 on patients’ gut microbiomes, adding another layer to our understanding of these interactions. Ultimately, while vitamin C showed promise, the overall picture suggests that it's part of a broader landscape of factors affecting ulcerative colitis.
9.5
No side effects
Most Useful Review
Vitamin C in its Ester form is gentle on the stomach, which is important for those with ulcers. I've experienced no side effects from this variant.
