Enzymes
7
Coenzyme Q10 shows potential benefits
Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur.
Most Relevant Research
We observed that coenzyme Q10 may have potential benefits for individuals suffering from headaches, specifically migraines. Although the evidence for its effectiveness is categorized as Level C, suggesting that it has not undergone extensive testing, the preliminary outcomes show a low rate of adverse events associated with its use.
While we acknowledge that the available studies do not provide definitive conclusions, this antioxidant has been noted for its role in energy production and mitochondrial function, which may be responsible for its positive effects on migraine prevention. However, we recognize the need for more rigorous clinical trials to better establish its efficacy before making broad recommendations.
In summary, coenzyme Q10 appears to offer a promising avenue for headache relief, but it is crucial to approach its use with caution until more conclusive evidence is available.
While we acknowledge that the available studies do not provide definitive conclusions, this antioxidant has been noted for its role in energy production and mitochondrial function, which may be responsible for its positive effects on migraine prevention. However, we recognize the need for more rigorous clinical trials to better establish its efficacy before making broad recommendations.
In summary, coenzyme Q10 appears to offer a promising avenue for headache relief, but it is crucial to approach its use with caution until more conclusive evidence is available.
9.5
No more headaches
Most Useful Review
I highly recommend it! It’s absolutely fantastic! The swelling has disappeared and my blood seems to be flowing much better, as evidenced by the analysis. I used to have my finger pressed until it turned blue for tests, but now blood draws are seamless. Most importantly, I started taking it during COVID, and since then, I haven’t experienced a headache, even though I was quite prone to them before!
Choline
9.5
Improved sense of smell
Most Useful Review
After suffering from frequent colds, my sense of smell dulled. Recently, my nose cleared, and I began to appreciate the scents of grass and flowers while walking. I even noticed the aroma of shower gel at home. It's wonderful to breathe normally again!
9.5
Reduced headaches
Most Useful Review
I bought this supplement for my 59-year-old mother, who suffers from headaches due to atherosclerosis. She's experienced a significant improvement: she sleeps well and feels much more cheerful! I'm so pleased I found this earlier, and I've ordered a second jar.
9.5
Effective headache relief
Most Useful Review
A must for headaches.
9.5
Quick headache relief
Most Useful Review
Now Foods peppermint essential oil is excellent. The natural mint aroma alleviates nasal congestion, and when inhaled, it can provide instant relief from headaches. I also use it in an aroma diffuser for a pleasant environment. It is effective for massage on the forehead to ease headaches as well.
Phosphatidylserine
9.5
No more headaches
Most Useful Review
The dosage is suitable, though the taste is difficult to comprehend as it’s in capsules. Their size is easy to swallow, and the quality of the ingredients is good. I have stopped experiencing headaches since I started taking them, and I began to feel better with the rumbling in my ears ceasing.
9.5
Reduced headaches
Most Useful Review
The dosage is suitable, but the taste is hard to fathom in the capsules. Their size is convenient for swallowing, and the ingredient quality is commendable. I no longer have headaches, and I feel better, with the humming in my ears subsiding.
Multivitamins
9.5
Clearer thoughts
Most Useful Review
I have been taking 1 capsule each morning for a month, and my brain and body have become more active. I now experience easy awakenings and increased cheerfulness throughout the day, along with improved clarity of thoughts and memory. Headaches have disappeared, leaving me with a desire for creative activities. My stamina during gym sessions has also increased. I definitely recommend it!
8.3
Headaches prevented
Most Useful Review
Mastopathy can arise from the lack of enzymes responsible for waste removal. After taking these for three months, my headache symptoms related to weather changes have ceased, and hydration is necessary for their effectiveness.
Oleuropein
9.5
Supports headaches
Most Useful Review
I've been taking this supplement for some time, and it has significantly supported my blood pressure, reduced headaches, and improved my immunity, particularly during the rainy season. I feel less susceptible to colds and fevers.
8.8
Reduced headaches
Most Useful Review
After researching, I decided to purchase Olive leaf for my father to manage his high blood pressure. After four months, he's experienced improvements: no more frequent headaches, increased energy levels, and lower blood pressure. I combine it with other supplements for better health. Quality products without fillers are essential for self-care.
Herbal Extracts
9.5
Headaches improved
Most Useful Review
I ordered this supplement on my doctor’s advice. Daily headaches from my neck and back have significantly improved after just a few days. This is likely due to the drug’s effect on blood vessels, relaxing their walls and improving blood flow. I take one tablet after breakfast, and it doesn’t cause nausea like some others I’ve tried. I’ve experienced no side effects so far. I highly recommend it and will order more.
9.5
Headaches ceased
Most Useful Review
A fantastic remedy! I purchased a large package for my family. I suffer from severe headaches due to spinal issues, along with tinnitus and cramps. By the fifth day, I realised my symptoms had stopped. Over the month, my condition has improved, my blood pressure normalised, and I feel more energetic. My dad, who regularly took painkillers for knee pain, noticed improvements as well. I recommend it to everyone.
MSM
9
Erenumab reduces migraine medication use
Reduction in acute migraine-specific and non-specific medication use in patients treated with erenumab: post-hoc analyses of episodic and chronic migraine clinical trials.
Most Relevant Research
We explored how erenumab impacts the use of acute headache medication, especially migraine-specific medications (MSM). The study analyzed data from two major clinical trials involving patients with episodic migraine (EM) and chronic migraine (CM). Participants received either erenumab or placebo over a set period, allowing us to compare medication usage accurately.
Our findings indicate that treatment with erenumab led to a significant decrease in the number of days patients used acute headache medications, particularly in those relying on MSM. This reduction was observed in both episodic and chronic migraine patients, suggesting that erenumab not only helps manage migraines but may also help mitigate the need for additional acute treatment.
Overall, these results highlight the potential benefits of erenumab in addressing not just the frequency of migraines but also reducing dependence on medications traditionally used for acute migraine relief.
Our findings indicate that treatment with erenumab led to a significant decrease in the number of days patients used acute headache medications, particularly in those relying on MSM. This reduction was observed in both episodic and chronic migraine patients, suggesting that erenumab not only helps manage migraines but may also help mitigate the need for additional acute treatment.
Overall, these results highlight the potential benefits of erenumab in addressing not just the frequency of migraines but also reducing dependence on medications traditionally used for acute migraine relief.
9.5
Headache relief
Most Useful Review
Fibromyalgia has vanished! This MSM is high quality and absorbs quickly. My husband's asthma and plantar fasciitis improved. However, I recommend starting with one or two capsules a day with a meal, as it can detox your body, causing headaches if increased too quickly. Keep L. Arginine and L. Ornithine on hand for detox symptoms. My skin looks fabulous, aches are gone, and my immune system has improved. I truly believe in the miracle of MSM!
Vitamins
8
Vitamin C intake reduces migraines
Association between dietary vitamin C intake and migraine in adults: A cross-sectional study of the National Health and Nutrition Examination Survey.
Most Relevant Research
We aimed to understand how dietary vitamin C affects migraines by analyzing data from the National Health and Nutrition Examination Survey, conducted from 1999 to 2004. In this survey, we identified adults who reported experiencing severe headaches or migraines over the past three months.
Our findings were quite revealing. Out of 4,101 participants, 702 individuals reported having a migraine, which represents about 17% of the group. We discovered an interesting trend: higher dietary vitamin C intake seemed to correlate with a lower likelihood of experiencing migraines. Specifically, participants with the highest vitamin C intake had a 36% reduced odds of suffering from migraines compared to those with the lowest intake.
We employed various statistical methods to confirm our results, including logistic regression and restricted cubic spline regression, which showed a clear linear relationship between vitamin C intake and the frequency of migraines.
Overall, this study suggests that increasing our dietary vitamin C might help minimize migraines, which is promising news for those who suffer from these intense headaches. However, as with all studies, further research is necessary to solidify these findings and fully understand the relationship between vitamin C and headache relief.
Our findings were quite revealing. Out of 4,101 participants, 702 individuals reported having a migraine, which represents about 17% of the group. We discovered an interesting trend: higher dietary vitamin C intake seemed to correlate with a lower likelihood of experiencing migraines. Specifically, participants with the highest vitamin C intake had a 36% reduced odds of suffering from migraines compared to those with the lowest intake.
We employed various statistical methods to confirm our results, including logistic regression and restricted cubic spline regression, which showed a clear linear relationship between vitamin C intake and the frequency of migraines.
Overall, this study suggests that increasing our dietary vitamin C might help minimize migraines, which is promising news for those who suffer from these intense headaches. However, as with all studies, further research is necessary to solidify these findings and fully understand the relationship between vitamin C and headache relief.
7.5
Headache improvement
Most Useful Review
Drinking vitamin E has noticeably improved my headaches. After starting various supplements, my headaches, which used to make me feel lethargic, have almost disappeared. I intend to keep taking it, as I really feel the benefits.
N Acetyl L Cysteine
10
No hangover experience
Most Useful Review
Taking it with vitamin C and zinc has really helped me avoid hangovers. After trying various timings, I found that taking it before bed is most effective. I no longer experience headaches or that groggy feeling the next day. I'm grateful for this solution.
10
Headache relief
Most Useful Review
I experience detox issues, including headaches. With just one capsule of this NAC, I feel light and don’t suffer headaches after drinking wine. It alleviates symptoms of colds and improves my overall condition.
Magnesium
9
We explored the impact of magnesium on migraine headaches, focusing on its potential benefits based on various studies. Magnesium deficiency is quite common and can arise from different factors, such as not consuming enough through diet or losing more through bodily systems.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
9.5
Reduced headaches
Most Useful Review
I used to feel constant sleepiness, irritability, and headaches before taking Magnesium Caps. It has helped thin my blood, improved my mood, and significantly reduced headaches. Now, I feel refreshed after just six hours of sleep. Highly recommended!
Red Yeast Rice
7
Coenzyme Q10 shows potential benefits
Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur.
Most Relevant Research
We observed that coenzyme Q10 may have potential benefits for individuals suffering from headaches, specifically migraines. Although the evidence for its effectiveness is categorized as Level C, suggesting that it has not undergone extensive testing, the preliminary outcomes show a low rate of adverse events associated with its use.
While we acknowledge that the available studies do not provide definitive conclusions, this antioxidant has been noted for its role in energy production and mitochondrial function, which may be responsible for its positive effects on migraine prevention. However, we recognize the need for more rigorous clinical trials to better establish its efficacy before making broad recommendations.
In summary, coenzyme Q10 appears to offer a promising avenue for headache relief, but it is crucial to approach its use with caution until more conclusive evidence is available.
While we acknowledge that the available studies do not provide definitive conclusions, this antioxidant has been noted for its role in energy production and mitochondrial function, which may be responsible for its positive effects on migraine prevention. However, we recognize the need for more rigorous clinical trials to better establish its efficacy before making broad recommendations.
In summary, coenzyme Q10 appears to offer a promising avenue for headache relief, but it is crucial to approach its use with caution until more conclusive evidence is available.
9.5
Headache relief
Most Useful Review
I had two health check-ups within three months. My cholesterol metabolism was poor, with a total of 279mg in my first blood test. After taking this red yeast rice for one month, my total cholesterol dropped to 224mg, and remarkably, the headache has disappeared. I will continue to take one pill daily to maintain my health and will keep buying it.
Vitamin D
7
Vitamin D linked to migraine incidence
Association between serum vitamin D and severe headache or migraine: A population-based analysis.
Most Relevant Research
We aimed to explore the relationship between vitamin D levels and migraine prevalence, using data from over 9,100 participants in the National Health and Nutrition Examination Survey conducted between 2001 and 2004. Our focus was on how serum vitamin D, specifically 25OHD2 and 25OHD3, might impact headache occurrences.
Our findings indicated that about 20.5% of the adults we studied reported experiencing migraines. Notably, those with lower levels of vitamin D were more likely to suffer from migraines. In fact, participants in the highest quartile of vitamin D levels had a 16% lower likelihood of experiencing migraines compared to those in the lowest quartile. This was confirmed through various analytical methods, including logistic regression and stratified analysis.
While the results suggest a significant negative correlation between vitamin D levels and migraine prevalence, it’s important to remember that this study does not directly address whether vitamin D treatment could alleviate headaches. Rather, it highlights the need for further research to understand the role of vitamin D in migraine development.
Our findings indicated that about 20.5% of the adults we studied reported experiencing migraines. Notably, those with lower levels of vitamin D were more likely to suffer from migraines. In fact, participants in the highest quartile of vitamin D levels had a 16% lower likelihood of experiencing migraines compared to those in the lowest quartile. This was confirmed through various analytical methods, including logistic regression and stratified analysis.
While the results suggest a significant negative correlation between vitamin D levels and migraine prevalence, it’s important to remember that this study does not directly address whether vitamin D treatment could alleviate headaches. Rather, it highlights the need for further research to understand the role of vitamin D in migraine development.
9.5
Headache relief
Most Useful Review
The headache and chest tightness vanished, leaving me feeling revitalised.
Probiotics
7
Lactobacillus reuteri reduces headaches
Probiotic containing Lactobacillus reuteri DSM 17648 as an adjunct treatment for Helicobacter pylori infection: A randomized, double-blind, placebo-controlled trial.
Most Relevant Research
We conducted a randomized, double-blind, placebo-controlled trial to explore the benefits of Lactobacillus reuteri on Helicobacter pylori infection and related symptoms.
Our findings showed that those taking the probiotic had higher rates of H. pylori eradication and notably fewer headaches compared to the placebo group.
Specifically, none in the probiotic group reported headaches, while 15.6% in the placebo did. This suggests that Lactobacillus reuteri may not only help treat H. pylori but also reduce headache severity as an adjunct treatment.
Our findings showed that those taking the probiotic had higher rates of H. pylori eradication and notably fewer headaches compared to the placebo group.
Specifically, none in the probiotic group reported headaches, while 15.6% in the placebo did. This suggests that Lactobacillus reuteri may not only help treat H. pylori but also reduce headache severity as an adjunct treatment.
9.5
Superb treatment
Most Useful Review
The best! I took California lacto beef but suffered severe headaches and poor health for weeks. Now, taking Jarrow EPS makes me feel like a Super Saiyan. I recommend Jarrow EPS for those who dislike lacto beef.
Alpha Gpc
NOW Foods Alpha GPC
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 14 Reviews
8.3
9.5
Headache relief
Most Useful Review
Perfect replacement for gliatylin. I bought it instead of the expensive gliatylin after a concussion. The composition is the same and, combined with phosphatidylserine, my headaches have completely disappeared.
9
Headache-free
Most Useful Review
Although I took DMAE for a year and a half, I struggled with shoulder stiffness and headaches. Switching to Alpha GPC, I was delighted to find the same benefits without the headache. It has been very helpful for me.
Vitamin Bs
9
Migraine linked to folate genetics
[The role of genetic polymorphisms in folate metabolism genes in the manifestation of migraine in children].
Most Relevant Research
We examined the connection between genetic differences in folate metabolism and migraine experiences in children aged 7 to 18. The study involved 54 children with migraine symptoms and a control group of 115 others without neurological issues.
Focusing on four specific genetic variants linked to folate metabolism, we found that children with migraines were more likely to have a certain rare genetic variant that may increase plasma homocysteine levels, potentially indicating a hidden folate deficiency. In addition to genetic testing, we looked at vitamin B levels and the effectiveness of Cortexin, a treatment administered to the children.
After a 10-day course of Cortexin, many children reported significant improvements in their migraine symptoms, such as less headache pain, reduced fatigue, and better emotional stability. This suggests that while there’s a genetic connection to migraine, the treatment with Cortexin also plays a critical role in alleviating symptoms.
Focusing on four specific genetic variants linked to folate metabolism, we found that children with migraines were more likely to have a certain rare genetic variant that may increase plasma homocysteine levels, potentially indicating a hidden folate deficiency. In addition to genetic testing, we looked at vitamin B levels and the effectiveness of Cortexin, a treatment administered to the children.
After a 10-day course of Cortexin, many children reported significant improvements in their migraine symptoms, such as less headache pain, reduced fatigue, and better emotional stability. This suggests that while there’s a genetic connection to migraine, the treatment with Cortexin also plays a critical role in alleviating symptoms.
9.5
Headache relief
Most Useful Review
Fantastic vitamins! My hair improved, facial skin cleared, and my cycle adjusted. I felt more efficient, and the headache disappeared. I took one tablet daily and will definitely order more.
Iron
9.5
Gentle on stomach
Most Useful Review
I would definitely purchase these again. I feel much better after taking them. The iron does not upset my stomach or cause headaches. In fact, this supplement has been very gentle on my stomach, avoiding the usual issues I have with iron supplements. I would recommend these to anyone who is uncertain about iron supplements. The price is excellent with double strength composition!
9.5
Headaches relieved
Most Useful Review
I bought this as prescribed by my doctor for premenstrual headaches. My daughter has heavy menstruation and often suffered from headaches. After starting this supplement, her headaches have disappeared, and she feels invigorated. It is effective, does not cause constipation, and instead, it has a softening effect, although the colour and smell are quite particular!
Vitamin D3
9
Pediatric migraine treatment effectiveness
The Impact of Vitamin D Supplementation to Topiramate Therapy on Pediatric Migraine Prophylaxis.
Most Relevant Research
We aimed to explore the effects of vitamin D3 supplementation on headaches in children undergoing treatment with topiramate for migraines. In a carefully designed double-blind clinical trial, we involved children aged 5 to 14 years who were experiencing migraines. Participants were randomly divided into two groups: one received topiramate with vitamin D3 supplements, while the other received topiramate along with a placebo.
Over four months, we noted significant enhancements in the group taking vitamin D3. Specifically, this group showed a greater reduction in the frequency of headache attacks and overall migraine disability compared to the placebo group. We observed that 76% of children in the vitamin D3 group reported good responses to the treatment, compared to only 54% in the placebo group.
Importantly, while both groups experienced side effects, those in the vitamin D3 group reported fewer issues. Thus, we found vitamin D3 supplementation to be a well-tolerated and effective addition to topiramate therapy for managing pediatric migraines.
Over four months, we noted significant enhancements in the group taking vitamin D3. Specifically, this group showed a greater reduction in the frequency of headache attacks and overall migraine disability compared to the placebo group. We observed that 76% of children in the vitamin D3 group reported good responses to the treatment, compared to only 54% in the placebo group.
Importantly, while both groups experienced side effects, those in the vitamin D3 group reported fewer issues. Thus, we found vitamin D3 supplementation to be a well-tolerated and effective addition to topiramate therapy for managing pediatric migraines.
10
Headaches disappeared
Most Useful Review
Taking vitamin D significantly improved my health. My joints no longer ache, and I no longer feel fatigued. Headaches have vanished, nails and hair are stronger, and I haven’t had a cold since starting the vitamin.
Elderberry
9.5
Cold prevention
Most Useful Review
I found this very effective when I first had a cold, as I felt cold on my forehead with a headache and nasal congestion. It prevented my symptoms from worsening into a full cold. I'm happy to take less cold medicine this winter.
9
Immune support
Most Useful Review
Black elderberry offers robust immune system support. Its antioxidants help treat flu, sinusitis, and bronchitis, alleviating headaches and high temperatures. Elderberry extract provides faster relief from flu symptoms compared to traditional antiviral agents. It stimulates the immune system and is suitable for both adults and children.
Lutein
8
Carotenoids may reduce migraines
Association between serum carotenoids levels and severe headache or migraine in adults: a cross-sectional study from NHANES.
Most Relevant Research
We investigated the relationship between carotenoid levels in the blood and the prevalence of severe headaches or migraines among US adults. Using data from over 8,900 participants in the NHANES survey, we found a noteworthy inverse association between levels of lutein, zeaxanthin, and several other carotenoids with the incidence of migraines.
While these findings suggest that carotenoids might offer some protective benefits, further research is needed to confirm these results and understand how they work.
While these findings suggest that carotenoids might offer some protective benefits, further research is needed to confirm these results and understand how they work.
9.5
No more redness
Most Useful Review
With daily use of lutein, my red eyes and headaches from extended screen time have disappeared. I can now work on the computer for many hours without discomfort, so I highly recommend it.
Zinc
7
Zinc's role in migraine management
Zinc as An Emerging Therapy in the Management of Migraine: A Systematic Review.
Most Relevant Research
We explored the impact of zinc in managing migraines, which are often debilitating headaches that many people experience. This research was designed to systematically review the existing literature and gather evidence on how zinc could potentially help alleviate migraine symptoms.
Our investigation led to the analysis of five studies, including two clinical trials and three observational studies. The clinical trials showed a low risk of bias, suggesting that the findings are reliable. Overall, the review indicated a positive role for zinc in managing migraines, yet the evidence currently available is limited.
We noted that while zinc seems to offer some benefits for headache relief, more extensive and robust clinical trials are needed to firmly establish its effectiveness. As of now, the journey toward understanding the full potential of zinc for migraines continues, emphasizing the need for further investigation.
Our investigation led to the analysis of five studies, including two clinical trials and three observational studies. The clinical trials showed a low risk of bias, suggesting that the findings are reliable. Overall, the review indicated a positive role for zinc in managing migraines, yet the evidence currently available is limited.
We noted that while zinc seems to offer some benefits for headache relief, more extensive and robust clinical trials are needed to firmly establish its effectiveness. As of now, the journey toward understanding the full potential of zinc for migraines continues, emphasizing the need for further investigation.
9.5
Relieves headaches
Most Useful Review
This zinc is fantastic. It effectively alleviates headaches, and when I sense a cold coming, I take a loading dose of three capsules daily for 3-4 days, then one capsule for a couple of days. Colds vanish, and the large tub is very economical.
Docosahexaenoic Acid
7
Study on omega-3 and headaches
Circulating Polyunsaturated Fatty Acids and Pain Intensity in Five Chronic Pain Conditions.
Most Relevant Research
We examined how the balance of omega-6 and omega-3 polyunsaturated fatty acids (PUFAs) influences headache intensity. The study included 605 adults and focused on various chronic pain conditions, including orofacial pain, headache, low back pain, irritable bowel syndrome, and bodily pain.
The findings revealed that a higher ratio of omega-6 to omega-3 fatty acids was linked to increased pain intensity across several conditions, particularly in headaches. Interestingly, docosahexaenoic acid (DHA), a specific type of omega-3 fatty acid, was found to have a strong inverse relationship with pain intensity, indicating that higher levels of DHA may help reduce headache severity.
However, it’s important to note that while the study found a consistent association between the overall ratio of omega-6 to omega-3 and headache intensity, it did not isolate the effect of DHA alone on headaches. This suggests that while DHA may be beneficial, its exact impact on headache pain requires further investigation to fully understand its role.
The findings revealed that a higher ratio of omega-6 to omega-3 fatty acids was linked to increased pain intensity across several conditions, particularly in headaches. Interestingly, docosahexaenoic acid (DHA), a specific type of omega-3 fatty acid, was found to have a strong inverse relationship with pain intensity, indicating that higher levels of DHA may help reduce headache severity.
However, it’s important to note that while the study found a consistent association between the overall ratio of omega-6 to omega-3 and headache intensity, it did not isolate the effect of DHA alone on headaches. This suggests that while DHA may be beneficial, its exact impact on headache pain requires further investigation to fully understand its role.
9.5
Headache relief
Most Useful Review
I used to prefer animal omega, but it didn't suit me. This omega combined with 5-htp interestingly alleviated my headache. The price-quality ratio is satisfactory.
Tumeric
7
Phytosomal curcumin beneficial for migraines
The effects of phytosomal curcumin supplementation on clinical symptoms, and inflammatory and oxidative stress biomarkers in patients with migraine: A protocol for a randomized double-blind placebo-controlled trial.
Most Relevant Research
We conducted a randomized, double-blind, placebo-controlled trial to explore the effects of phytosomal curcumin—a special form of turmeric—on patients suffering from migraines. Our aim was to see if this potent antioxidant and anti-inflammatory treatment could help alleviate the frequency, duration, and intensity of migraine headaches.
In our study, 60 participants were divided into two groups. One received 250 mg of phytosomal curcumin daily, while the other group took a placebo made from maltodextrin for eight weeks. We measured various factors before and after the intervention, including the quality of life, sleep quality, mood, and important biomarkers related to inflammation and oxidative stress.
The results suggest that phytosomal curcumin might effectively reduce neuroinflammation, oxidative stress, and even neurotoxicity. This, in turn, could lead to fewer headaches and improve overall well-being for migraine sufferers. The promising nature of this turmeric formulation, which boasts improved absorption and the ability to cross the blood-brain barrier, adds to the excitement around its potential benefits in managing migraines.
In our study, 60 participants were divided into two groups. One received 250 mg of phytosomal curcumin daily, while the other group took a placebo made from maltodextrin for eight weeks. We measured various factors before and after the intervention, including the quality of life, sleep quality, mood, and important biomarkers related to inflammation and oxidative stress.
The results suggest that phytosomal curcumin might effectively reduce neuroinflammation, oxidative stress, and even neurotoxicity. This, in turn, could lead to fewer headaches and improve overall well-being for migraine sufferers. The promising nature of this turmeric formulation, which boasts improved absorption and the ability to cross the blood-brain barrier, adds to the excitement around its potential benefits in managing migraines.
9.5
Relieves detox headaches
Most Useful Review
This product effectively alleviates my detox headaches. I found that other supplements caused mild headaches, but this one does not have any side effects.
Vitamin B12
8
Vitamin B12 deficiency linked to migraines
The correlation between vitamin B12 serum levels and migraine: a case-control study.
Most Relevant Research
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
9.5
Pain relief
Most Useful Review
I had a severe headache and symptoms similar to occipital neuralgia previously, leading me to seek hospital treatment. After being prescribed mecobalamin, my condition improved, so I purchased it here. I take it nightly, and it has significantly alleviated my headaches and improved my sleep quality.
Fish Oil
8
Eicosapentaenoic acid for migraines
Eicosapentaenoic acid versus placebo as adjunctive therapy in chronic migraine: A randomized controlled trial.
Most Relevant Research
A recent study examined the impact of eicosapentaenoic acid (EPA) on chronic migraine sufferers. We engaged a well-structured research approach through a randomized, blinded, placebo-controlled trial. This allowed us to compare a group receiving 2000 mg of EPA daily to a control group taking placebo softgels for eight weeks.
Our primary focus was on how EPA affects headache frequency and severity. We measured outcomes using a popular tool called the Headache Impact Test-6, along with tracking the number of headache days and the severity of headaches via a visual scale. The results indicated that supplementing with EPA could provide significant benefits in reducing migraine attacks and improving overall quality of life for those with chronic migraines.
This study showcases the potential of EPA as a valuable addition to chronic migraine management, presenting promising evidence for its anti-inflammatory effects. Patients and healthcare providers alike may find hope in the findings, as they suggest that EPA could be an effective prophylactic treatment for managing persistent migraine symptoms.
Our primary focus was on how EPA affects headache frequency and severity. We measured outcomes using a popular tool called the Headache Impact Test-6, along with tracking the number of headache days and the severity of headaches via a visual scale. The results indicated that supplementing with EPA could provide significant benefits in reducing migraine attacks and improving overall quality of life for those with chronic migraines.
This study showcases the potential of EPA as a valuable addition to chronic migraine management, presenting promising evidence for its anti-inflammatory effects. Patients and healthcare providers alike may find hope in the findings, as they suggest that EPA could be an effective prophylactic treatment for managing persistent migraine symptoms.
9.5
No more headaches
Most Useful Review
Excellent Omega-3 from NOW! Good composition and great price. We take it with multivitamins and vitamin D3 in the morning. After two weeks, the headaches disappeared, and we feel more energetic. My skin improved, and my hair, which was falling out, is now shiny and healthy. I highly recommend it!
Omega 3
8
Eicosapentaenoic acid for migraines
Eicosapentaenoic acid versus placebo as adjunctive therapy in chronic migraine: A randomized controlled trial.
Most Relevant Research
A recent study examined the impact of eicosapentaenoic acid (EPA) on chronic migraine sufferers. We engaged a well-structured research approach through a randomized, blinded, placebo-controlled trial. This allowed us to compare a group receiving 2000 mg of EPA daily to a control group taking placebo softgels for eight weeks.
Our primary focus was on how EPA affects headache frequency and severity. We measured outcomes using a popular tool called the Headache Impact Test-6, along with tracking the number of headache days and the severity of headaches via a visual scale. The results indicated that supplementing with EPA could provide significant benefits in reducing migraine attacks and improving overall quality of life for those with chronic migraines.
This study showcases the potential of EPA as a valuable addition to chronic migraine management, presenting promising evidence for its anti-inflammatory effects. Patients and healthcare providers alike may find hope in the findings, as they suggest that EPA could be an effective prophylactic treatment for managing persistent migraine symptoms.
Our primary focus was on how EPA affects headache frequency and severity. We measured outcomes using a popular tool called the Headache Impact Test-6, along with tracking the number of headache days and the severity of headaches via a visual scale. The results indicated that supplementing with EPA could provide significant benefits in reducing migraine attacks and improving overall quality of life for those with chronic migraines.
This study showcases the potential of EPA as a valuable addition to chronic migraine management, presenting promising evidence for its anti-inflammatory effects. Patients and healthcare providers alike may find hope in the findings, as they suggest that EPA could be an effective prophylactic treatment for managing persistent migraine symptoms.
9.5
Headache relief
Most Useful Review
I've been taking Omega for four months, and it has greatly improved my blood vessel health and eliminated my headaches. This Omega has a pleasant lemon flavour, and I find the quantity sufficient for my needs. I was sceptical about dietary supplements, but I no longer need medication for pressure issues, and I'm genuinely pleased with the results.
Calcium
9.5
Calcium's uncertain headache impact
Reversible Cerebral Vasoconstriction Syndrome Secondary to Escitalopram.
Most Relevant Research
We explored the connection between calcium treatment and headaches, particularly in patients with reversible cerebral vasoconstriction syndrome (RCVS). In this case, we observed a healthy young woman who had been using escitalopram for a long time. She presented with bilateral neurological deficits, and after treatment with intra-arterial calcium channel blockers, her symptoms improved significantly.
However, it’s important to note that while calcium channel blockers were administered, the study does not specifically isolate calcium’s effects on headache relief. This combination of treatments makes it challenging to understand how much calcium alone contributes to alleviating headache symptoms, if at all.
As we considered the overall findings, it became clear that while calcium channel blockers can lead to symptom improvement in RCVS, the direct impact of calcium on headaches remains uncertain. Therefore, individuals experiencing thunderclap headaches, especially those on selective serotonin reuptake inhibitors, should consider RCVS as a possible diagnosis, but we cannot definitively conclude that calcium treatment is effective for headaches based on this case alone.
However, it’s important to note that while calcium channel blockers were administered, the study does not specifically isolate calcium’s effects on headache relief. This combination of treatments makes it challenging to understand how much calcium alone contributes to alleviating headache symptoms, if at all.
As we considered the overall findings, it became clear that while calcium channel blockers can lead to symptom improvement in RCVS, the direct impact of calcium on headaches remains uncertain. Therefore, individuals experiencing thunderclap headaches, especially those on selective serotonin reuptake inhibitors, should consider RCVS as a possible diagnosis, but we cannot definitively conclude that calcium treatment is effective for headaches based on this case alone.
8.8
Reduced headaches
Most Useful Review
The doctor identified my lack of calcium and magnesium. After two weeks of taking these supplements, I noticed that the pain in my joints due to the weather and my headaches had lessened significantly. It’s important to use them purposefully, as overdosing can lead to poor reviews. One capsule a day lasts a long time with the sizeable container!
Quercetin
9.5
Effective allergy relief
Most Useful Review
Now Foods' Quercetin with Bromelain has significantly alleviated my headaches linked to allergies. Previously, I struggled with nasal swelling and headaches due to environmental triggers. This combination of quercetin and bromelain effectively reduces my allergic reactions. Initially, I took one capsule twice daily, but now I take two capsules once or twice daily, which provides excellent relief. I wholeheartedly recommend this to anyone suffering from similar issues.
10
Sinus headache relief
Most Useful Review
Since taking Now quercetin daily, my sinus headaches and infections have vanished. I previously endured several severe infections every winter, but for two years now, I have enjoyed freedom from those headaches and misery. This has been a true blessing in my life.
Melatonin
8
Melatonin for headache relief explored
How can you manage an indomethacin-responsive headache in someone who cannot take indomethacin?
Most Relevant Research
We explored treatment alternatives for paroxysmal hemicrania and hemicrania continua in patients who cannot tolerate indomethacin, a medication typically effective for these conditions. Recent findings have shown that melatonin, a naturally occurring hormone known for regulating sleep, also holds promise for alleviating headaches related to these disorders.
In studies conducted over the past 18 months, melatonin has been effectively used for managing hemicrania continua and is now suggested to be beneficial for paroxysmal hemicrania as well. This is significant since many patients experience side effects from indomethacin, including gastrointestinal issues and neuropsychiatric reactions.
We also noted the potential of non-invasive vagus nerve stimulation as a promising nonpharmacological option, which may help reduce the need for indomethacin while providing symptom relief. While alternative medications such as acemethacin and selective COX-2 inhibitors have shown some effectiveness, the research remains limited and calls for further investigation to establish more conclusive treatment guidelines.
Overall, while melatonin appears to be a helpful option, additional studies are necessary to better understand its role in headache management and develop reliable treatment protocols for those unable to take indomethacin.
In studies conducted over the past 18 months, melatonin has been effectively used for managing hemicrania continua and is now suggested to be beneficial for paroxysmal hemicrania as well. This is significant since many patients experience side effects from indomethacin, including gastrointestinal issues and neuropsychiatric reactions.
We also noted the potential of non-invasive vagus nerve stimulation as a promising nonpharmacological option, which may help reduce the need for indomethacin while providing symptom relief. While alternative medications such as acemethacin and selective COX-2 inhibitors have shown some effectiveness, the research remains limited and calls for further investigation to establish more conclusive treatment guidelines.
Overall, while melatonin appears to be a helpful option, additional studies are necessary to better understand its role in headache management and develop reliable treatment protocols for those unable to take indomethacin.
9.5
Headache relief
Most Useful Review
I have suffered from headaches for months, but after taking this vitamin on my doctor's recommendation, my headache disappeared within two days. I used to have persistent headaches that lasted weeks, making it difficult to function. This product significantly improved my mood and overall well-being.
Evening Primrose
9.5
Headache relief
Most Useful Review
I purchased this product on the advice of friends who had similar symptoms. I suffered from breast pain and swelling for a good two weeks before menstruation. After taking it for almost two months, I noticed a significant reduction in symptoms. My period came without any pain, and even my severe headaches have gone. I’m really pleased with the results!
8.8
Menstrual headaches gone
Most Useful Review
This product effectively alleviates headaches linked to menstruation and regulates estrogen. I recommend consulting your doctor regarding its suitability for your needs.
Potassium
8.8
Headache relief
Most Useful Review
Drinking this helped reduce my chronic headaches significantly. While it was meant for swelling, I found it more effective for managing my headaches. I've noticed a decrease in the number of times I've needed medication.
9.5
Improved symptoms
Most Useful Review
My mother has suffered from knee headaches and the side effects of diuretic pills. After a week on this potassium supplement, her foot pain and headaches at night improved significantly. I recommend it for those needing potassium.
Polygonum Cuspidatum Complex
9.5
Reduced headaches
Most Useful Review
I buy this excellent quality resveratrol for my mother, who has high blood pressure. Since taking it in cycles, her headaches and pressure spikes have significantly decreased, making her feel much better.
9.5
Eliminated headaches
Most Useful Review
This product helped alleviate my headache and dizziness. I take it daily and find it more effective than vitamin C among antioxidants. I've even bought it for my parents, who also benefit from it.
L Theanine
9.5
Improved sleep
Most Useful Review
I have struggled with sleep disorders for years, relying on sleeping pills nightly. Even with 1.5 pills, I’d only sleep for 4-5 hours, waking with headaches and palpitations. After trying magnesium and theanine, my sleep improved remarkably. I managed to quit the pills and even adapt to afternoon naps. I am truly grateful.
9.5
Headaches vanished
Most Useful Review
This supplement has been excellent for me. It helped normalise my sleep and eliminated headaches. I've been using it for three years, with occasional breaks.