Enzymes
7
Nattokinase identified as allergen
Nattokinase (Bac s 1), a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto.
Most Relevant Research
We examined the effects of nattokinase, a protease found in natto, on allergies. Our study involved eight individuals who experienced allergic reactions after consuming natto, specifically the sticky substance surrounding the beans. Some participants tested negative for polygamma glutamic acid (PGA), which was previously identified as a potential allergen.
Throughout our investigation, we employed skin prick tests, immunoblotting, and ELISA to assess the reactivity to nattokinase and other components. Notably, we discovered that a subset of patients, particularly those who were negative for PGA, exhibited an allergic response to nattokinase. This finding suggests that nattokinase may act as a distinct allergen in certain individuals.
In the end, we identified nattokinase as a new allergen linked to natto allergy, particularly in those not sensitized to PGA. While our study highlights the allergenic potential of nattokinase, its broader implications for allergy treatment remain to be fully explored.
Throughout our investigation, we employed skin prick tests, immunoblotting, and ELISA to assess the reactivity to nattokinase and other components. Notably, we discovered that a subset of patients, particularly those who were negative for PGA, exhibited an allergic response to nattokinase. This finding suggests that nattokinase may act as a distinct allergen in certain individuals.
In the end, we identified nattokinase as a new allergen linked to natto allergy, particularly in those not sensitized to PGA. While our study highlights the allergenic potential of nattokinase, its broader implications for allergy treatment remain to be fully explored.
9.5
Increased energy
Most Useful Review
I genuinely appreciate this vitamin. I often feel tired, but since taking this supplement, my energy levels have improved significantly. It’s also suitable for vegans, which is great for those with allergies.
Apple Pectin
9.5
Allergy relief
Most Useful Review
Pectin is a fantastic remedy for my gastrointestinal tract. I've suffered from allergies for years; however, after my doctor recommended a combination of Psyllium, Inulin, and Pectin, I've been living fully without hormonal allergy medications for three years. My order arrived quickly, and I definitely prefer this particular pectin over others I've tried. I find it neatly packaged, and the capsules are medium-sized and easy to take with warm water in the morning. Since starting this at age 40, my bowel movements have normalised, unpleasant odours have ceased, and I've lost 10 kg. The initial bloating from the first week passed quickly, and I highly recommend it.
10
Effective solution
Most Useful Review
The effect is wonderful, and it dissolves delicately in water. My allergies disappeared, and my intestinal discomfort ceased. I take it 1.5 hours after meals or two capsules at night, and I can mix it with warm water or kefir. My intestines have cleared more rapidly, and I recommend everyone give it a try.
Vitamin B Complex
9.5
Increased vitality noted
Most Useful Review
I’ve taken the B-Right complex from Jarrow Formulas for a year and highly regard it as the best available. Its composition offers an excellent blend of B vitamins, including choline which promotes blood formation and improves emotional stability. The results for me have been remarkable: boosted energy levels and a calmer mindset. I consume one capsule daily and feel no adverse side effects, making it suitable for my sensitivities, especially concerning allergies.
10
Enhances energy levels
Most Useful Review
This complex of B vitamins is the only one that doesn’t trigger allergies for me. I felt energised and alert throughout the day. It truly lifts my spirits during my studies.
9.5
Effective for allergies
Most Useful Review
My purchase was based on the composition, and I was immediately taken by the fabulous aroma. It suits my sensitive skin well, particularly with papaya and neem. One small drop is enough to thoroughly cleanse my face without drying. It leaves my skin fresh and not tight, perfect for daily use. I also bought a toner to complement it, and this duo is now a favourite of mine. I recommend it!
9.5
No allergies
Most Useful Review
Favourite treats for my children; they can enjoy five pieces without allergies.
Multivitamins
9.5
No allergies reported
Most Useful Review
The best vitamins for expectant mothers and those breastfeeding. I experienced allergies with other brands, but these are balanced with all necessary vitamins and minerals. I felt light, and my hair and nails improved. They are GMO-free and safe, though a bit pricey.
9.5
No allergies experienced
Most Useful Review
Well absorbed, without side effects; they don't cause allergies, making them suitable during pregnancy and after childbirth.
Quercetin
9
Quercetin shows promise in allergies
In-silico exploring pathway and mechanism-based therapeutics for allergic rhinitis: Network pharmacology, molecular docking, ADMET, quantum chemistry and machine learning based QSAR approaches.
Most Relevant Research
We delved into the potential of quercetin as a therapeutic option for treating allergic rhinitis, a common condition affecting roughly 40% of the global population. This study utilized various in-silico approaches, such as network pharmacology and molecular docking, to identify compounds from traditional medicinal plants and assess their effectiveness.
Among the 241 compounds analyzed, quercetin stood out due to its strong binding affinities with important targets linked to inflammatory and immune pathways. Our assessments indicated that quercetin could interact effectively with key cytokines involved in allergic reactions, potentially reducing allergy symptoms.
While the study highlighted promising implications for quercetin, it did not isolate its effects from other examined compounds. Therefore, further experimental testing is needed to affirm its benefits and effectiveness in real-world allergy treatment situations.
Among the 241 compounds analyzed, quercetin stood out due to its strong binding affinities with important targets linked to inflammatory and immune pathways. Our assessments indicated that quercetin could interact effectively with key cytokines involved in allergic reactions, potentially reducing allergy symptoms.
While the study highlighted promising implications for quercetin, it did not isolate its effects from other examined compounds. Therefore, further experimental testing is needed to affirm its benefits and effectiveness in real-world allergy treatment situations.
8.8
Effective for allergies
Most Useful Review
Excellent tool! Before ordering this drug, I read that Quercetin with Bromelain strengthens the immune system and helps with allergies. Since I started taking one capsule per day, my allergy symptoms have improved within a week. I'm looking forward to the ageing benefits too. Thank you for the excellent service!
Vitamin A
9
Vitamin A and allergy management
Retinoic Acid (RA): A Critical Immunoregulatory Molecule in Asthma and Allergies.
Most Relevant Research
Our exploration into the effects of vitamin A, particularly its active form known as retinoic acid, revealed some interesting insights regarding allergies. Vitamin A plays a key role in our immune system by helping to regulate immune responses, which is crucial for managing allergic reactions.
Research indicates that retinoic acid can promote the development of regulatory T cells, which are essential for maintaining balance in our immune system. These T cells help to suppress excessive immune responses that can lead to allergies. Additionally, they assist in managing inflammatory responses, which is particularly important for conditions like asthma and allergic reactions.
Notably, studies have shown that levels of retinoic acid are often lower in individuals suffering from asthma and allergies. Moreover, introducing retinoic acid as a treatment has been found to alleviate symptoms associated with allergies and reduce airway inflammation. This suggests that boosting retinoic acid levels in the body might be a promising therapeutic approach for those dealing with allergic conditions.
Overall, we conclude that vitamin A—through its derivative retinoic acid—holds significant potential for improving allergy management by enhancing immune regulation.
Research indicates that retinoic acid can promote the development of regulatory T cells, which are essential for maintaining balance in our immune system. These T cells help to suppress excessive immune responses that can lead to allergies. Additionally, they assist in managing inflammatory responses, which is particularly important for conditions like asthma and allergic reactions.
Notably, studies have shown that levels of retinoic acid are often lower in individuals suffering from asthma and allergies. Moreover, introducing retinoic acid as a treatment has been found to alleviate symptoms associated with allergies and reduce airway inflammation. This suggests that boosting retinoic acid levels in the body might be a promising therapeutic approach for those dealing with allergic conditions.
Overall, we conclude that vitamin A—through its derivative retinoic acid—holds significant potential for improving allergy management by enhancing immune regulation.
9.5
Skin improvement
Most Useful Review
25,000 IU is a high dose but suitable for my allergies and atrophoderma. Initially, I had skin breakouts, but after a day, my skin improved. Within two weeks, facial inflammation cleared up. The overall condition of my skin has significantly improved, a result I previously only achieved with injections.
Spirulina
9.5
Effective for allergies
Most Useful Review
Spirulina is a remarkable seaweed that is fully absorbed by our bodies. It improves blood composition, removes heavy metals, and supports liver function. Notably, it alleviates allergies without hindering the immune system. Instead, it cleanses and reduces inflammation, offering a natural solution.
9.5
Allergy improvement
Most Useful Review
Since taking spirulina, my allergies have significantly decreased. I feel much better now, thanks to its benefits.
MSM
9.5
Allergy relief
Most Useful Review
MSM resolves hair, skin, and joint issues, as well as allergies. My mother’s seasonal joint pain is gone, and her nails and hair are noticeably healthier. She uses it every fall and spring.
10
Cured allergies
Most Useful Review
I've been taking sulphur for five years. It helps with overall body health and effectively manages my allergies. I highly recommend it for anyone dealing with similar issues.
Iron
8
Allergy management in iron treatments
From diagnosis to desensitization in immediate hypersensitivity reactions to both oral and parenteral iron salts.
Most Relevant Research
We examined the rise of hypersensitivity reactions (HRs) linked to iron agents, especially as their usage in treating iron deficiency has increased. In this study, we evaluated the clinical features of patients who experienced immediate hypersensitivity reactions (IHRs) to both oral and intravenous (IV) iron preparations.
Our analysis included the medical records of 96 patients with a history of these reactions. Among them, 47 had reactions to oral iron, while 49 reacted to IV iron. We conducted skin-prick tests with various iron salts, but found that these tests weren't very helpful for diagnosing IHRs. In fact, only a small percentage showed a positive reaction.
Interestingly, we noted that patients who were sensitive to IV iron experienced more severe reactions, including cases of anaphylaxis. Despite the challenges in diagnosing these allergies, we successfully conducted desensitization treatments for 15 patients needing iron, specifically using ferric carboxymaltose. This approach proved to be safe and effective, marking an important option for patients requiring iron therapy despite their hypersensitivity.
Our analysis included the medical records of 96 patients with a history of these reactions. Among them, 47 had reactions to oral iron, while 49 reacted to IV iron. We conducted skin-prick tests with various iron salts, but found that these tests weren't very helpful for diagnosing IHRs. In fact, only a small percentage showed a positive reaction.
Interestingly, we noted that patients who were sensitive to IV iron experienced more severe reactions, including cases of anaphylaxis. Despite the challenges in diagnosing these allergies, we successfully conducted desensitization treatments for 15 patients needing iron, specifically using ferric carboxymaltose. This approach proved to be safe and effective, marking an important option for patients requiring iron therapy despite their hypersensitivity.
9.5
No allergies noted
Most Useful Review
Excellent hardware. It raised my sister's hemoglobin; it didn't work the first time. No allergies were identified.
Flax Seed Oil
9.5
Great for vegans
Most Useful Review
I have been using this product for years and found it on Iherb at a great price! As a vegan family with nut allergies, we rely on flaxseed oil for healthy fats. It's gluten-free, organic, and highly recommended!
9.5
Excellent fish oil alternative
Most Useful Review
An excellent source of healthy fats for people with fish allergies. I've been taking it for years for a friend, and it is the best product of its kind!
Oleuropein
9.5
Effective for allergies
Most Useful Review
I enjoy using this for seasonal allergies, and it works particularly well with oil of oregano.
10
No allergy issues
Most Useful Review
The brand has a good composition, and I’ve experienced no allergy issues with the ingredients.
L Lysine
9.5
Eases allergic reactions
Most Useful Review
I have been using this product for a long time; it helped my mum get rid of allergies and eases my allergic reactions. Friends who drink it found it helpful in controlling herpes.
8.8
Effective for allergies
Most Useful Review
Great quality. The Thorne brand caused an allergic reaction on my hands, but this one works well for me against EBV herpes and the latest virus.
Oregano
9.5
Effective allergy treatment
Most Useful Review
I have been using this product since autumn 2009, alongside my allergy and asthma medications. Over time, I noticed significant improvements and eventually stopped refilling my prescriptions. I take this with NOW brand Quercetin and Bromelain, and I no longer need my allergy or asthma prescriptions. During allergy season, I will increase the dosage while monitoring to avoid asthma attacks.
9.5
Minimised symptoms
Most Useful Review
I’ve been off Claritin for a week and am only taking this 1-2 times a day. I usually suffer greatly during allergy season, but this has really helped to minimise my symptoms. It's the only natural remedy that has worked for me so far.
Vitamin Bs
7
Vitamin B12 hypersensitivity studied
Vitamin B Hypersensitivity: A Retrospective Multicenter Study.
Most Relevant Research
We explored a group of 29 patients who were referred to three allergy centers in the UK due to suspected vitamin B12 hypersensitivity (VB12H). Over the period from 2014 to 2022, these patients underwent various tests, including skin prick tests and drug provocation tests. The aim was to understand how vitamin B12 treatment relates to allergies and to develop a reliable method for assessing hypersensitivity.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
9.5
Diminished food allergies
Most Useful Review
A niacin deficiency apparently hindered my serotonin production. After supplementation, I noticed improved mental stability and posture. Surprisingly, my food allergies have also improved significantly, and the scratches I used to have on my skin while sleeping have nearly disappeared.
Olive Leaf
9.5
Effective immune support
Most Useful Review
This product truly boosts my immune system. I take three capsules daily, and my allergies and chronic runny nose have completely vanished. It's amazing.
8.8
Reduced allergy symptoms
Most Useful Review
I’m delighted I tried this alternative to allergy medications. After a few weeks of taking three capsules a day, most of my allergy symptoms have either disappeared or lessened significantly.
Silybum Marianum
9
Silibinin shows promise for asthma
Silibinin attenuates allergic airway inflammation in mice.
Most Relevant Research
We examined how silibinin, a compound found in milk thistle, affects allergic asthma in a mouse model. Our findings showed that silibinin significantly helped reduce airway inflammation and hyperresponsiveness, mainly by targeting the NF-κB pathway. This suggests that silibinin might offer protective benefits against allergic airway conditions by moderating inflammatory responses. While our research found promising results in mice, further studies are necessary to confirm its effectiveness in human asthma treatment.
9.5
Allergies disappeared
Most Useful Review
Random allergies vanished after taking Silymarin alongside multivitamins. I had suffered from fatigue and skin rashes for years, but felt more energised and noticed my skin had returned to normal. I was surprised as dermatologists had said my issues were due to allergies from my sensitive skin. I'm pleased with the results and plan to continue with a second bottle.
Probiotics
9
Lactobacillus KBL409 reduces atopic dermatitis
Lactobacillus acidophilus KBL409 Ameliorates Atopic Dermatitis in a Mouse Model.
Most Relevant Research
We explored the effects of Lactobacillus acidophilus KBL409 on atopic dermatitis (AD) using a house dust mite-induced mouse model. The treatment notably lowered dermatitis symptoms and reduced immune cell infiltration in the skin. Additionally, it decreased levels of specific immune markers and increased anti-inflammatory responses.
L. acidophilus KBL409 also positively influenced gut microbiota and certain metabolites. The findings suggest that this probiotic may offer a promising approach to managing AD through immune system modulation and gut health improvement.
L. acidophilus KBL409 also positively influenced gut microbiota and certain metabolites. The findings suggest that this probiotic may offer a promising approach to managing AD through immune system modulation and gut health improvement.
9.5
Minimises allergies
Most Useful Review
Very good probiotics! This product contains four essential bacteria types at a good concentration. I noticed improved skin and reduced allergies in my child after giving him one capsule. It has helped immensely with his digestion issues from birth. I highly recommend it for anyone looking to boost immunity and minimise allergies!
Elderberry
9.5
Effective for allergies
Most Useful Review
I sought a remedy for my child’s allergies, who suffers from sores on his cheek. After notably positive recommendations, I tried elderberry. It proved effective; after just two capsules, the sores began to clear up. Even half a capsule is ample for my child.
9.5
Supports immunity
Most Useful Review
I take elderberry for immune support alongside omega, vitamins D and C, and propolis. I haven't fallen ill, and I believe the combination is beneficial. The elderberry doesn't cause allergies, and my stomach tolerates it well. I will continue using it.
Vitamin C
8
Pleuran and Vitamin C aid asthma
Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma.
Most Relevant Research
We conducted a thorough evaluation of how vitamin C, when combined with pleuran, impacts asthma control and respiratory issues in children suffering from perennial asthma. The study was meticulously designed as a double-blind, placebo-controlled trial involving 230 children aged 7 to 17 years. This means that neither the participants nor the researchers knew who was receiving the active treatment or the placebo, ensuring the findings were reliable.
The results were promising, especially for children under 12 years. They showed significant improvements in asthma control compared to those receiving only the placebo treatment. Meanwhile, older children (12 years and above) experienced fewer respiratory infections with the combination treatment. Overall, by the end of the 48 weeks, a majority of children on the pleuran and vitamin C treatment reported better asthma control compared to those on the placebo.
While the combination of pleuran and vitamin C was indeed beneficial for managing asthma, we must note that the study did not specifically isolate the effect of vitamin C alone on allergies or asthma. Thus, it is hard to draw definitive conclusions about vitamin C's effectiveness independently from pleuran. However, the approach suggested that using these supplements together could offer a helpful boost in managing asthma symptoms.
The results were promising, especially for children under 12 years. They showed significant improvements in asthma control compared to those receiving only the placebo treatment. Meanwhile, older children (12 years and above) experienced fewer respiratory infections with the combination treatment. Overall, by the end of the 48 weeks, a majority of children on the pleuran and vitamin C treatment reported better asthma control compared to those on the placebo.
While the combination of pleuran and vitamin C was indeed beneficial for managing asthma, we must note that the study did not specifically isolate the effect of vitamin C alone on allergies or asthma. Thus, it is hard to draw definitive conclusions about vitamin C's effectiveness independently from pleuran. However, the approach suggested that using these supplements together could offer a helpful boost in managing asthma symptoms.
9.5
Helps prevent illnesses
Most Useful Review
Good vitamin C! The jar lasts a long time and does not irritate my stomach. It is well absorbed and does not cause allergies. We take a loading dose at the first signs of ARVI, which helps the whole family avoid getting ill.
Zinc
9
Zinc and QES alleviate allergies
Quail Egg-Based Supplements in Allergic Rhinitis: A Systematic Review of Clinical Studies.
Most Relevant Research
We delved into the effectiveness of zinc treatment in managing allergic rhinitis, aided by a systematic review of clinical studies. Our exploration began with a thorough search of major databases, revealing insights from five clinical reports that met the necessary criteria for inclusion. These studies involved participants ranging from 40 to 180 individuals, providing a balanced mix of genders.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
9.5
Skin condition improvement
Most Useful Review
I bought these pills for my atopic dermatitis. After struggling with various treatments, I tried zinc picolinate, as it’s better absorbed. Amazingly, the itching has now gone, and my skin is no longer dry. My husband even remarked on how delicate my skin looks!
Potassium
9.5
No allergies noted
Most Useful Review
I feel good after starting this supplement; there were no allergies or side effects. I highly recommend it.
8.3
Reliable and effective
Most Useful Review
This potassium citrate complex from a reliable manufacturer is very effective for allergies and did not cause any allergies or nausea. I recommend purchasing it.
Bromelain
9.5
Significant effects
Most Useful Review
Bromelain does more than aid digestion; I include it in my regimen for seasonal allergies and as an anti-inflammatory for arthritis. Its effects are impressive, and I take it consistently, as I have found it to be very effective.
9.8
Eliminates histamine
Most Useful Review
These enzymes have worked wonders for my seasonal allergies. I take two capsules daily away from meals, which has almost entirely stopped my histamine production, allowing me to enjoy being outdoors without a runny nose or itchy eyes. It also significantly improved my chronic sinusitis, although I experienced some pain due to flushing out kidney stones. Staying hydrated is essential.
Biotin
9.5
Inhibits itch production
Most Useful Review
Atopy and allergies! High concentrations of biotin are beneficial. After 20 years on antihistamines, I sought to stop them and began taking biotin. I found that biotin aids in eliminating essential amino acids like histidine, which helps metabolise histamine, thereby alleviating the itch.
9.5
Notable skin improvement
Most Useful Review
After suffering from daily skin infections due to allergies, I decided to try biotin. Within two weeks of taking it, there was a noticeable improvement in my skin and an increase in energy. This supplement made a significant difference for me.
Vitamin D3
8
Vitamin D3 may support asthma treatment
Correlation Analysis of Serum 25-Hydroxyvitamin D Levels With Immune Function and Calcium-Phosphate Metabolism in Patients With Bronchial Asthma Treated With Combination Therapy.
Most Relevant Research
We investigated the effects of combining vitamin D3 with fluticasone propionate inhalation aerosol in children with bronchial asthma. Our study involved 110 patients who were divided into two groups: one receiving only the inhalation treatment and the other receiving both the inhalation treatment and vitamin D3. By comparing these groups, we aimed to understand how vitamin D3 could potentially enhance immune function and improve symptoms related to asthma.
Results indicated that the group receiving the combination treatment experienced a quicker relief from symptoms like wheezing and dyspnea. They also showed marked improvements in lung function and quality of life. Particularly interesting was the observation that this treatment regime increased serum levels of vitamin D3, several immunoglobulins, and T lymphocyte subsets, which are important for immune health. Furthermore, the combination was linked with beneficial changes in calcium and phosphorus levels in the bloodstream.
However, while our findings suggest a positive relationship between vitamin D3 levels and immune function, we should note that the isolated benefits of vitamin D3 alone on allergies could not be conclusively determined. The results highlight potential benefits, but more research would be necessary to pinpoint vitamin D3's role specifically in allergy management, independent of other treatments.
Overall, our exploration reinforces the need to consider vitamin D3 as a potential supportive treatment in asthma management, especially given its immunomodulatory effects. Yet, it's essential to approach these findings with caution until further evidence is gathered on its direct impact on allergies.
Results indicated that the group receiving the combination treatment experienced a quicker relief from symptoms like wheezing and dyspnea. They also showed marked improvements in lung function and quality of life. Particularly interesting was the observation that this treatment regime increased serum levels of vitamin D3, several immunoglobulins, and T lymphocyte subsets, which are important for immune health. Furthermore, the combination was linked with beneficial changes in calcium and phosphorus levels in the bloodstream.
However, while our findings suggest a positive relationship between vitamin D3 levels and immune function, we should note that the isolated benefits of vitamin D3 alone on allergies could not be conclusively determined. The results highlight potential benefits, but more research would be necessary to pinpoint vitamin D3's role specifically in allergy management, independent of other treatments.
Overall, our exploration reinforces the need to consider vitamin D3 as a potential supportive treatment in asthma management, especially given its immunomodulatory effects. Yet, it's essential to approach these findings with caution until further evidence is gathered on its direct impact on allergies.
9.5
No allergies
Most Useful Review
Good day. Today, I'm reviewing liquid vitamin D3 for children. I liked these vitamins. The quality is good, and they caused no allergies. The dispenser is convenient, and the composition includes only vitamin D and coconut oil. The packaging is nice, and the size is small. The taste and smell are neutral, which is perfect for children. I recommend these vitamins for maintaining your child's immunity.
Red Yeast Rice
8
Co-Q10 aids allergic reaction control
The effect of Co-Q10 on allergic rhinitis and allergic asthma.
Most Relevant Research
We investigated how coenzyme Q10 (Co-Q10) affects allergies, particularly allergic rhinitis and asthma. In our study, we used animal models to mimic these conditions and treated them with Co-Q10, either alone or alongside other compounds like Omega-3 and magnesium sulfate.
We collected and analyzed samples from the lungs, measuring various inflammatory markers such as cytokines and IgE levels, which play critical roles in allergic reactions. The results indicated that Co-Q10 helps promote the activity of a protective protein called Nrf2, which is crucial in defending against allergic responses and inflammation.
By increasing Nrf2 levels, Co-Q10 showed potential in reducing the symptoms associated with allergic conditions, helping to control allergic mediators and inflammatory factors. Overall, we found that Co-Q10 treatment could enhance the body’s resilience to allergens, potentially offering a powerful tool against allergic rhinitis and asthma.
We collected and analyzed samples from the lungs, measuring various inflammatory markers such as cytokines and IgE levels, which play critical roles in allergic reactions. The results indicated that Co-Q10 helps promote the activity of a protective protein called Nrf2, which is crucial in defending against allergic responses and inflammation.
By increasing Nrf2 levels, Co-Q10 showed potential in reducing the symptoms associated with allergic conditions, helping to control allergic mediators and inflammatory factors. Overall, we found that Co-Q10 treatment could enhance the body’s resilience to allergens, potentially offering a powerful tool against allergic rhinitis and asthma.
9.5
No allergies noted
Most Useful Review
Excellent quality product with perfectly chosen ingredients that did not cause any allergies. The large packaging is sufficient for a long time, and the capsules are of average size with a neutral taste. I noticed improvements in my intestinal function and metabolism within a week. My nervous system feels better, and I am less anxious. The effectiveness of this vitamin is undeniable.
Magnesium
9.5
Effective for allergies
Most Useful Review
I've been using this vitamin for over six months and honestly can't live without it. It has greatly helped my allergies, asthma, and fatigue. The energy boost I get is remarkable, and I can't fathom my day without it!
9.5
Dust allergy relief
Most Useful Review
I've suffered from dust allergies for ages, and last autumn was particularly hard. However, after cleaning my closet this March without sneezing, I realised this magnesium supplement, which I started in February, made the difference. I hadn't thought it would affect my allergies, but I'm glad it did.
Echinacea
9
Echinacea may alleviate allergies
Echinacea purpurea water extracts suppress the release of chemical mediators from mast cells.
Most Relevant Research
We explored how Echinacea purpurea, a plant commonly used in herbal tea, might help relieve allergies by focusing on its effects on mast cells. Mast cells play a significant role in type-I allergies, such as hay fever, by releasing histamine and leukotrienes—substances that cause allergic symptoms.
Our evaluation involved water extracts from the petals, leaves, and stems of Echinacea purpurea. We specifically looked at how these extracts influenced the release of histamine and other chemical mediators from mast cell lines. The results were quite interesting: both petal and leaf extracts significantly reduced histamine release in stimulated cells. However, the stem extract did not show any effect.
Notably, we found that the petal extract was much more effective than the leaf extract. Additionally, all extracts effectively suppressed leukotriene B4 production, which is another mediator involved in allergic reactions. The petal extract also seemed to decrease certain cellular signaling events associated with mast cell activation.
Overall, our findings suggest that Echinacea purpurea petal extract could potentially help alleviate allergic symptoms, particularly in conditions like hay fever.
Our evaluation involved water extracts from the petals, leaves, and stems of Echinacea purpurea. We specifically looked at how these extracts influenced the release of histamine and other chemical mediators from mast cell lines. The results were quite interesting: both petal and leaf extracts significantly reduced histamine release in stimulated cells. However, the stem extract did not show any effect.
Notably, we found that the petal extract was much more effective than the leaf extract. Additionally, all extracts effectively suppressed leukotriene B4 production, which is another mediator involved in allergic reactions. The petal extract also seemed to decrease certain cellular signaling events associated with mast cell activation.
Overall, our findings suggest that Echinacea purpurea petal extract could potentially help alleviate allergic symptoms, particularly in conditions like hay fever.
8.8
Effective for allergies
Most Useful Review
On a friend's recommendation, I've long wanted to try echinacea. She spoke enthusiastically about how it helps her family with colds all year round. I chose this brand for its vegan capsules. When I first feel unwell, I take two capsules 3-4 times a day along with vitamin C, which helps me recover quickly! Just be cautious if you're prone to allergies. Fortunately, I did not experience any reactions, despite my own allergy history.
Fish Oil
9.5
Docosahexaenoic acid helps asthma
Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase alleviate ovalbumin‑induced allergic asthma in mice by reducing airway inflammation and oxidative stress.
Most Relevant Research
We explored the potential of lipid mediators derived from docosahexaenoic acid (DHA) for alleviating allergic asthma. Using a model where mice were challenged with ovalbumin (OVA) to induce asthma-like symptoms, we administered lipid mediators that included 17S-monohydroxy DHA, resolvin D5, and protectin DX. These treatments led to significant improvements in key aspects of asthma such as reduced inflammatory cell infiltration and lower levels of Th2 cytokines.
Following treatment with the lipid mediators, we observed decreased levels of interleukin-6, tumor necrosis factor-α, and IgE—important markers associated with allergic reactions. There was a notable reduction in inflammation and oxidative stress in lung tissues, which suggests a protective effect on the lungs. Additionally, histological examinations revealed fewer signs of inflammation and mucus secretion.
The results indicate that DHA-derived lipid mediators may effectively mitigate the symptoms of allergic asthma and offer a promising new approach for treatment. They seem to act by reducing inflammation and improving antioxidant defenses within the lungs.
Following treatment with the lipid mediators, we observed decreased levels of interleukin-6, tumor necrosis factor-α, and IgE—important markers associated with allergic reactions. There was a notable reduction in inflammation and oxidative stress in lung tissues, which suggests a protective effect on the lungs. Additionally, histological examinations revealed fewer signs of inflammation and mucus secretion.
The results indicate that DHA-derived lipid mediators may effectively mitigate the symptoms of allergic asthma and offer a promising new approach for treatment. They seem to act by reducing inflammation and improving antioxidant defenses within the lungs.
9.5
Preventing allergies
Most Useful Review
Omega-3 is vital for health, especially to prevent allergies and cardiovascular diseases. These acids are crucial as a deficiency can lead to serious health issues. The product contains effective doses of DHA and EPA, essential for overall well-being. Given their importance, I take these regularly and have observed positive health improvements.
Docosahexaenoic Acid
9.5
Docosahexaenoic acid helps asthma
Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase alleviate ovalbumin‑induced allergic asthma in mice by reducing airway inflammation and oxidative stress.
Most Relevant Research
We explored the potential of lipid mediators derived from docosahexaenoic acid (DHA) for alleviating allergic asthma. Using a model where mice were challenged with ovalbumin (OVA) to induce asthma-like symptoms, we administered lipid mediators that included 17S-monohydroxy DHA, resolvin D5, and protectin DX. These treatments led to significant improvements in key aspects of asthma such as reduced inflammatory cell infiltration and lower levels of Th2 cytokines.
Following treatment with the lipid mediators, we observed decreased levels of interleukin-6, tumor necrosis factor-α, and IgE—important markers associated with allergic reactions. There was a notable reduction in inflammation and oxidative stress in lung tissues, which suggests a protective effect on the lungs. Additionally, histological examinations revealed fewer signs of inflammation and mucus secretion.
The results indicate that DHA-derived lipid mediators may effectively mitigate the symptoms of allergic asthma and offer a promising new approach for treatment. They seem to act by reducing inflammation and improving antioxidant defenses within the lungs.
Following treatment with the lipid mediators, we observed decreased levels of interleukin-6, tumor necrosis factor-α, and IgE—important markers associated with allergic reactions. There was a notable reduction in inflammation and oxidative stress in lung tissues, which suggests a protective effect on the lungs. Additionally, histological examinations revealed fewer signs of inflammation and mucus secretion.
The results indicate that DHA-derived lipid mediators may effectively mitigate the symptoms of allergic asthma and offer a promising new approach for treatment. They seem to act by reducing inflammation and improving antioxidant defenses within the lungs.
9.5
Immediate moisturising effect
Most Useful Review
The ingredients are excellent and suitable for my fish allergies. The quality is fantastic as I noticed an immediate moisturising effect on my skin from the second day. I also appreciate that there is no aftertaste; it is sweet and easy to swallow.
Polygonum Cuspidatum Complex
9.5
Improved immunity
Most Useful Review
Super strong antioxidants help significantly with my allergies and cardiovascular issues. I used to suffer from a severe runny nose, needing a roll of paper daily. After a week on resveratrol, my runny nose vanished. My stamina and mental clarity improved—especially noticeable before exams. If I'm ill and feverish, I take eight tablets a day and recover quickly. Amazing, isn't it?
7.5
Reduced severity
Most Useful Review
Since taking these pills, my allergies have been much less severe, and my energy levels have increased significantly.
Vitamin D
5
Vitamin D may help allergies
Vitamin D Supplementation and Allergic Rhinitis: A Systematic Review and Meta-Analysis.
Most Relevant Research
We examined the role of vitamin D supplementation in managing allergic rhinitis through a systematic review and meta-analysis. By reviewing randomized controlled trials focused on patients with allergic rhinitis, we aimed to determine the effectiveness of vitamin D in alleviating symptoms.
Our findings indicate that vitamin D may help reduce allergic rhinitis symptoms compared to placebos; however, the improvement was not statistically significant. We also discovered considerable variation among the studies we analyzed, pointing toward the complexities of measuring vitamin D's effects.
Interestingly, factors like the proportion of female participants and the use of corticosteroids impacted how patients responded to vitamin D. Specifically, vitamin D supplementation that was not paired with corticosteroids showed a more substantial impact on relieving symptoms.
While vitamin D appears to offer some benefits for allergic rhinitis, the overall effect may depend on individual circumstances, including gender and medication use. Thus, it's essential to consider these aspects when evaluating treatment options for allergies.
Our findings indicate that vitamin D may help reduce allergic rhinitis symptoms compared to placebos; however, the improvement was not statistically significant. We also discovered considerable variation among the studies we analyzed, pointing toward the complexities of measuring vitamin D's effects.
Interestingly, factors like the proportion of female participants and the use of corticosteroids impacted how patients responded to vitamin D. Specifically, vitamin D supplementation that was not paired with corticosteroids showed a more substantial impact on relieving symptoms.
While vitamin D appears to offer some benefits for allergic rhinitis, the overall effect may depend on individual circumstances, including gender and medication use. Thus, it's essential to consider these aspects when evaluating treatment options for allergies.
9.5
Allergy improvement noted
Most Useful Review
I tried this vitamin for a month, and it really helped me. I lost some weight, my allergy issues improved, and I felt more energetic than ever. It was definitely worth the money.
N Acetyl L Cysteine
8.8
Helps bronchial allergies
Most Useful Review
After a prolonged period with bronchial allergies, taking NAC reduced the frequency of my attacks, and I plan to continue using it.
7.5
Maintains clear sinuses
Most Useful Review
Regular use of NAC keeps my nasal passages clear, even with my allergies. This brand is effective among those I've tried.
Omega 3
8
Eicosapentaenoic acid and allergies
[Analysis of the effect of early subcutaneous specific immunotherapy on the levels of dust mite allergen-specific antibodies and polyunsaturated fatty acid metabolism].
Most Relevant Research
We aimed to understand how eicosapentaenoic acid, a type of beneficial fat known as a polyunsaturated fatty acid, interacts with allergy treatments like subcutaneous immunotherapy (SCIT). In our study, we assessed the effects of SCIT on patients allergic to dust mites, focusing on changes in specific antibodies and fatty acid metabolism over 12 months.
Notably, after treatment, eicosapentaenoic acid levels were observed to decrease in certain patient groups. While this may seem discouraging at first, we also uncovered new connections between eicosapentaenoic acid and specific allergy-related immune responses. For instance, we found that higher levels of certain fatty acids, including eicosapentaenoic acid, positively correlated with increases in dust mite-specific antibodies, suggesting a complex interplay between nutrition and immune function during allergy treatment.
Despite the intricate relationships we uncovered, we did not find any significant standalone benefits of eicosapentaenoic acid treatment used independently for allergies. Our research remains pivotal in helping us explore potential ties between dietary fats and allergic reactions, setting the stage for future studies to delve deeper into these relationships.
Notably, after treatment, eicosapentaenoic acid levels were observed to decrease in certain patient groups. While this may seem discouraging at first, we also uncovered new connections between eicosapentaenoic acid and specific allergy-related immune responses. For instance, we found that higher levels of certain fatty acids, including eicosapentaenoic acid, positively correlated with increases in dust mite-specific antibodies, suggesting a complex interplay between nutrition and immune function during allergy treatment.
Despite the intricate relationships we uncovered, we did not find any significant standalone benefits of eicosapentaenoic acid treatment used independently for allergies. Our research remains pivotal in helping us explore potential ties between dietary fats and allergic reactions, setting the stage for future studies to delve deeper into these relationships.
9
Effective for dryness
Most Useful Review
I found this product lovely as it does not cause allergies. During winter, when my hands were exceptionally dry, the cream failed to help. However, the fish oil significantly alleviated the dryness, although I needed to be cautious with the dosage—1 capsule 1-2 times a week—to avoid abdominal swelling and discomfort.
Vitamins
7
Vitamin D3 improves allergy treatments
Vitamin D3 improves the effects of low dose Der p 2 allergoid treatment in Der p 2 sensitized BALB/c mice.
Most Relevant Research
We explored how adding vitamin D3 to a low dose of an allergen treatment called Der p 2 allergoid might improve outcomes for those sensitized to this allergen. In our study, we used a mouse model specifically designed to mimic the allergic response to Der p 2. By comparing mice treated with vitamin D3 alongside the allergen treatment to control groups that received either only vitamin D3 or the allergen alone, we aimed to assess the effectiveness of this combination.
Our findings suggest that incorporating vitamin D3 can indeed boost the effects of the allergoid treatment. This addition not only helps in reducing the amount of allergen needed but also enhances the therapy's immunomodulatory effects, which could improve how patients manage their treatment and stick to it. It’s exciting to think about how this approach could lead to more effective and cost-efficient allergy therapies down the line.
Our findings suggest that incorporating vitamin D3 can indeed boost the effects of the allergoid treatment. This addition not only helps in reducing the amount of allergen needed but also enhances the therapy's immunomodulatory effects, which could improve how patients manage their treatment and stick to it. It’s exciting to think about how this approach could lead to more effective and cost-efficient allergy therapies down the line.
9.5
Essential for allergies
Most Useful Review
We take natural vitamin E regularly as a family. Its price and quality are excellent, and it’s indispensable for individuals with allergies and problem skin, complementing primary treatments. For women over 40, it is essential for maintaining a youthful appearance.
Melatonin
9.5
Sleep improvement
Most Useful Review
I purchased this as my child occasionally wakes in the night and struggles to settle back. Initially, I was apprehensive about administering it, but when things became challenging, I opted to give it a try. To my surprise, there was a notable effect within 15 minutes, and my child did not experience allergies from the medication, even though they often did before. Their sleep significantly improved! I highly recommend it and urge others not to be afraid; it's an excellent product!
9.5
Calm sleep
Most Useful Review
These melatonin tablets have been incredibly helpful in establishing healthier sleep for my child. After starting the treatment, their sleep became calmer and more regular, leading to noticeable improvements in their overall mood. The natural composition is beneficial, and it doesn't seem to cause any allergies or addiction. Administering them is easy as my child finds the taste pleasant. I recommend these melatonin pills for children struggling with sleep issues as they normalise sleep effectively.
Calcium
8.8
Strengthened nails
Most Useful Review
Good vitamins! They positively affect the body, though the benefit is cumulative. The dosage is good, and while the tablets are large, I have no difficulty swallowing. They did not cause allergies or side effects, and my nails have strengthened.
9.5
Recommended for mothers
Most Useful Review
After giving birth, my hair and nails were in a poor state. This calcium and magnesium saved me from my child's allergies to multivitamin complexes! I recommend it to young mothers.
Urtica Dioica
9
Urtica dioica reduces allergy inflammation
Urtica dioica attenuates ovalbumin-induced inflammation and lipid peroxidation of lung tissues in rat asthma model.
Most Relevant Research
We looked at how Urtica dioica, or nettle, could help tackle asthma-related inflammation. In a study with Wistar rats, we compared the effects of nettle extract against a control group. After giving the extract for 25 days, results showed a significant decrease in inflammatory markers and oxidative stress. The rats given nettle experienced up to a 60% drop in certain inflammatory cells and a notable reduction in lipid peroxidation in their lungs. These findings suggest that nettle might have protective benefits against airway inflammation caused by allergens.
9.5
Allergy relief
Most Useful Review
First of all, I purchased it to combat my allergies. I began taking it at the peak of my symptoms when pharmacy treatments ceased to work, and on the fourth day, my allergies disappeared. I feel like a normal person again. I bought two jars, which should last the season.
Wild Caught Fish Oil
8
Eicosapentaenoic acid and allergies
[Analysis of the effect of early subcutaneous specific immunotherapy on the levels of dust mite allergen-specific antibodies and polyunsaturated fatty acid metabolism].
Most Relevant Research
We aimed to understand how eicosapentaenoic acid, a type of beneficial fat known as a polyunsaturated fatty acid, interacts with allergy treatments like subcutaneous immunotherapy (SCIT). In our study, we assessed the effects of SCIT on patients allergic to dust mites, focusing on changes in specific antibodies and fatty acid metabolism over 12 months.
Notably, after treatment, eicosapentaenoic acid levels were observed to decrease in certain patient groups. While this may seem discouraging at first, we also uncovered new connections between eicosapentaenoic acid and specific allergy-related immune responses. For instance, we found that higher levels of certain fatty acids, including eicosapentaenoic acid, positively correlated with increases in dust mite-specific antibodies, suggesting a complex interplay between nutrition and immune function during allergy treatment.
Despite the intricate relationships we uncovered, we did not find any significant standalone benefits of eicosapentaenoic acid treatment used independently for allergies. Our research remains pivotal in helping us explore potential ties between dietary fats and allergic reactions, setting the stage for future studies to delve deeper into these relationships.
Notably, after treatment, eicosapentaenoic acid levels were observed to decrease in certain patient groups. While this may seem discouraging at first, we also uncovered new connections between eicosapentaenoic acid and specific allergy-related immune responses. For instance, we found that higher levels of certain fatty acids, including eicosapentaenoic acid, positively correlated with increases in dust mite-specific antibodies, suggesting a complex interplay between nutrition and immune function during allergy treatment.
Despite the intricate relationships we uncovered, we did not find any significant standalone benefits of eicosapentaenoic acid treatment used independently for allergies. Our research remains pivotal in helping us explore potential ties between dietary fats and allergic reactions, setting the stage for future studies to delve deeper into these relationships.
9.5
Significantly reduced allergies
Most Useful Review
I've noticed a significant reduction in my allergic reactions after taking this product for three months. My hay fever and pet allergies have decreased, allowing me to stop taking medication after ten years. Fish oil seems to work well for me.